Laboratory Medicine and Pathobiology Courses
Credit course for supervised participation in faculty research project. See page 40 for details.
Concepts in pathogenesis; cell injury and death; tissue structure, wound
healing; repair and fibrosis. Molecular basis of major organ system pathology.
The laboratory examines gross anatomical specimens and introduces histopathology.
Enrolment is limited to students specializing in pathobiology who have
completed the first and second year requirements of the program.
Introduces concepts and mechanisms of disease processes as they arise
from disturbances of normal biochemical and physiological functions. The
rational use of the clinical biochemistry laboratory in the diagnosis
and management of disease is explained. Not intended for students in the
Pathobiology Specialist program.
A general introduction to the cellular and molecular aspects of cancer
and its etiology. The laboratory component presents the range of benign
and malignant tumor types at the gross and histological levels. Pathophysiology
of cancer, invasion and metastases, role of the immune system.
Cellular and molecular components of the inflammatory response. Activation
of the inflammatory response by viral and microbial pathogens. Tissue
pathology resulting from the inflammatory response. Evolution of pathogens
to avoid and exploit the response.
The immune system in disease. Responses of the immune system to host
invasion, injurious stimuli, and transplantation. Immunopathology of organ-specific
diseases including pancreas, gut, liver, heart, kidney, and blood. Intended
for students specializing in pathobiology or related programs.
Focused broadly on the theme of calcium, from its cellular function and the endocrine systems regulating it, to bone structure and biomechanics. Selected bone diseases, their genetic variability, and treatment strategies are considered in depth.
A self-contained research project to be completed under the supervision
of a faculty member. The main areas of research are as listed in the description
of the Department (above). The student will normally have completed three
full years of study, and is expected to devote at least one full day per
week to the project. Admission is by arrangement with the Department and
with a particular supervisor. A list of potential supervisors is available
from the Departmental Office and on our web site.
Pathobiology of the heart, blood vessels, and lymphatic system. Congenital diseases of the heart, ischemic injury, stroke. Treatments of vascular disease and cardiovascular biomaterials. Major focus on atherosclerosis and hypertension. The emphasis is on the underlying cell biology of these processes.
Molecular mechanism involved in pathogenesis of infectious disease.
Topics include recurrent themes in the establishment of infectious disease,
such as adherence and spread of pathogenic bacteria as well as evasion
of host defences. Emphasis is placed on genetic characterization and expression
of virulence determinants and on interactions between bacterial pathogens
and their hosts.
Copyright © 2003, University of Toronto