MBY Microbiology Courses
Credit course for supervised participation in faculty research project. See page 40 for details.
Fundamental laboratory techniques in bacteriology and virology. Valuable
not only for students specializing in Microbiology but also for those
in related disciplines which make use of bacteria and viruses as research
tools. Open to students in related programs.
Detailed study of bacteria in terms of structure, classification and
replication. Basis for advanced study in various aspects of bacteriology
including bacterial physiology, bacterial genetics, molecular pathogenesis
of disease and environmental studies.
Detailed study of viruses in terms of structure, classification, replication
and interaction with the host. Basis for advanced study in virology. Requires
some familiarity with immunology. A concurrent course in immunology (IMM
334Y1/335Y1) is recommended.
Under the supervision of a departmental staff member. (Open only to
students who have completed Third Year with at least ‘B+’
This course aims to explore and understand microbial genome diversity
and the evolutionary dynamic of microbial genomes. Topics include: structure
and diversity of microbial (eubacterial and archaebacterial) genomes;
orientation and overall organization of genes at the genomic level; mobile
genetic elements; restriction and modification systems; genome and codon
How bacteria sense their environment and signal to regulatory systems
when to adapt to environmental stimuli. Topics discussed include the bacterial
cell cycle, carbon/energy metabolism, catabolite repression, bacterial
development, sporulation, stress responses, regulatory two-component systems
and quorum sensing.
Analysis of virus/host interactions at the molecular level. Course material
is based on recent research publications.
Microorganisms normally exist in mixed communities whose composition
and activity reflect the physical and chemical status of each particular
niche. The structural analysis, nutrient cycling, and dynamics of microbe-microbe
interactions in terrestrial, freshwater, and marine ecosystems are explored.
The role of microorganisms in bioremediation is examined.
Current approaches to gene therapy including design of virus-based vectors
for delivery and expression of effector genes. Emphasis on the use of
retrovirus-based strategies for prevention and treatment of HIV infection.
A laboratory course focussing on the use of molecular techniques to
study microorganisms and their interactions with the host.
Analysis of infectious disease vaccines; past, present and future, with
an emphasis on molecular aspects. Special topics include: molecular basis
of pathogenicity; vaccination strategies; genetically engineered vaccines;
DNA vaccines; modulation of the immune response by vaccine adjuvants;
adverse effects of vaccines.
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