BCH Biochemistry Courses
Credit course for supervised participation in faculty research project. See page 40 for details.
An introductory course in biochemistry covering proteins, enzymes, and metabolism. This course is intended for students who are NOT taking BCH242Y1 as part of their program.
An introduction to biochemistry for students specializing in biochemistry and related specialist programs. The major topics include protein structure, enzyme mechanisms, carbohydrates, metabolism and bioenenergetics, lipids, membranes, structure of DNA and RNA.
Principles and concepts of cell biology; structure, molecular organization and dynamic cell-cell and cell-extracellular matrix interactions during cell migration, cell adhesion, cell polarity and tissue organization and the role of cytoskeletal components and cell surface receptors in these processes. Approaches and imaging techniques used; contributions of cell biology to advances in medicine.
Principles and concepts of cell biology; structure, organization, biogenesis and dynamic behaviour of cell organelles with special emphasis on the nucleus and the role of vesicular transport in endocytosis, exocytosis and phagocytosis. Cell renewal, stem cells, cell growth and apoptosis will be presented. Approaches and modern imaging techniques used; contributions of cell biology to advances in medicine.
Structure of DNA and RNA. Catalytic RNAs (ribozymes). Aspects of DNA topology and chromatin structure. Restriction/modification and fundamentals of recombinant DNA technology.
Primary, secondary, tertiary and quaternary structure and predictions. Protein folding and chaperones. Techniques in protein structure analysis. Protein-ligand binding and protein-protein interactions. Protein sequence and structure databases, and introduction to proteomics.
An introduction to laboratory techniques of modern biochemistry. Experiments illustrate and develop the concepts described in lecture courses, and prepare the student for advanced training in biochemical laboratory techniques. (Enrolment limited)
Structure and biogenesis of cell surface membranes; relationship of structure to functional aspects of the cell surface, cell-cell interactions, transmembrane signals, hormone receptors, cell surface enzymes and transport.
Theory and practice of modern biophysical techniques as applied in the study of structure and function of macromolecules; emphasis on protein X-ray crystallography, NMR, and other spectroscopic methods; discussion of selected examples.
A variety of questions are investigated. How is calcium regulated in the cell and how does calcium regulate cell function? How are extracelluar signals received and transmitted by intracellular proteins to control cell proliferation and differentiation? What signalling pathways are triggered by insulin?
Molecular mechanisms involved in innate and adaptive immunity including the structure and, function of immunoglobulins, the complement system antigen processing and presentation, and membrane signalling events. Emphasis is on experimental approaches and quantitative aspects. (Given by the
Genetic code and tRNA. Aminoacyl-tRNA synthetases- structure and function. Structure of ribosomes and their role in translation. Protein synthesis. Translocation across membranes and the role of chaperones. Post-translational modifications, sorting, secretion, targeting.
This course covers the use of computers in biochemistry and molecular biology. The main topics include: structure and organization of sequence databases, genome databases, sequences alignment and search strategies, molecular evolution and methods for constructing phylogenetic trees. Recent advances in comparative genomics and proteomics are presented.
Research in a particular area of biochemistry, by arrangement with the Department and the instructor concerned.
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