| Course Winter Timetable |

BCH299Y1
Research Opportunity Program

Credit course for supervised participation in faculty research project. See page 40 for details.

BCH210H1
Introductory Biochemistry 39L

An introductory course in biochemistry covering proteins, enzymes, and metabolism. This course is intended for students who are NOT taking BCH242Y1 as part of their program.
Exclusion: BCH242Y1/310H1/320Y1/321Y1/CHM265H5(UTM)/ 379H1/361H5(UTM)/362H5(UTM)
Prerequisite: CHM138H1, CHM139H1

BCH242Y1
Biochemistry 78L

An introduction to biochemistry for students specializing in biochemistry and related specialist programs. The major topics include protein structure, enzyme mechanisms, carbohydrates, metabolism and bioenenergetics, lipids, membranes, structure of DNA and RNA.
Exclusion: BCH210H1/310H1/320Y1/321Y1/CHM265H5(UTM)/379H1/ 361H(UTM)/362H(UTM)
Prerequisite: CHM138H1, CHM139H1

BCH304H1
Cell Dynamics and Interactions 28L, 11T

Principles and concepts of cell biology; structure, molecular organization and dynamic cell-cell and cell-extracellular matrix interactions during cell migration, cell adhesion, cell polarity and tissue organization and the role of cytoskeletal components and cell surface receptors in these processes. Approaches and imaging techniques used; contributions of cell biology to advances in medicine.
Prerequisite: BIO250Y1, BCH210H1/BCH242Y1

BCH305H1
Organelles and Cell Function 28L, 11T

Principles and concepts of cell biology; structure, organization, biogenesis and dynamic behaviour of cell organelles with special emphasis on the nucleus and the role of vesicular transport in endocytosis, exocytosis and phagocytosis. Cell renewal, stem cells, cell growth and apoptosis will be presented. Approaches and modern imaging techniques used; contributions of cell biology to advances in medicine.
Prerequisite:BIO250Y1, BCH210H1/BCH242Y1

BCH335H1
Nucleic Acids and Recombinant DNA Technology 39L

Structure of DNA and RNA. Catalytic RNAs (ribozymes). Aspects of DNA topology and chromatin structure. Restriction/modification and fundamentals of recombinant DNA technology.
Exclusion: BCH430H1
Prerequisite: BCH242Y1

BCH340H1
Proteins: from Structure to Proteomics 39L

Primary, secondary, tertiary and quaternary structure and predictions. Protein folding and chaperones. Techniques in protein structure analysis. Protein-ligand binding and protein-protein interactions. Protein sequence and structure databases, and introduction to proteomics.
Exclusion: BCH421H1
Prerequisite: BCH242Y1

BCH370H1
Laboratory Course in Biochemical Techniques 13L, 39P

Techniques in biochemical research and analytical laboratories. Intended for students who are not proceeding further in biochemistry. (Enrolment limited)
Exclusion: BCH371H1
Prerequisite: BCH210H1

BCH371H1
A Laboratory Course in Biochemistry 75P

An introduction to laboratory techniques of modern biochemistry. Experiments illustrate and develop the concepts described in lecture courses, and prepare the student for advanced training in biochemical laboratory techniques. (Enrolment limited)
Exclusion: BCH370H1
Prerequisite: BCH242Y1
Note
Students who have completed University of Toronto at Mississauga’s CHM361H5 and 362H5 may enrol in 400-series lecture courses if they obtain permission of the Department

BCH422H1
Cell Surface Biochemistry 26L

Structure and biogenesis of cell surface membranes; relationship of structure to functional aspects of the cell surface, cell-cell interactions, transmembrane signals, hormone receptors, cell surface enzymes and transport.
Prerequisite: BCH210H1/BCH242Y1, MGB311Y1/BIO349H1

BCH425H1
Biophysical Methods 26L

Theory and practice of modern biophysical techniques as applied in the study of structure and function of macromolecules; emphasis on protein X-ray crystallography, NMR, and other spectroscopic methods; discussion of selected examples.
Prerequisite:BCH340H1/CHM379H1

BCH426H1
Signals Regulating Metabolic Pathways 26L

A variety of questions are investigated. How is calcium regulated in the cell and how does calcium regulate cell function? How are extracelluar signals received and transmitted by intracellular proteins to control cell proliferation and differentiation? What signalling pathways are triggered by insulin?
Prerequisite: BCH210H1/BCH242Y1, MGB311Y1/BIO349H1

JBI428H1
Molecular Immunology 26L

Molecular mechanisms involved in innate and adaptive immunity including the structure and, function of immunoglobulins, the complement system antigen processing and presentation, and membrane signalling events. Emphasis is on experimental approaches and quantitative aspects. (Given by the
Departments of Biochemistry and Immunology)
Prerequisite: BCH210H1/BCH242Y1, IMM334Y1/IMM335Y1
Recommended preparation: BIO349H1/MGB311Y1

BCH440H1
Protein Biosynthesis 26L

Genetic code and tRNA. Aminoacyl-tRNA synthetases- structure and function. Structure of ribosomes and their role in translation. Protein synthesis. Translocation across membranes and the role of chaperones. Post-translational modifications, sorting, secretion, targeting.
Prerequisite: BCH210H1/BCH242Y1, MGB311Y1/BIO349H1

BCH441H1
Bioinformatics 26L

This course covers the use of computers in biochemistry and molecular biology. The main topics include: structure and organization of sequence databases, genome databases, sequences alignment and search strategies, molecular evolution and methods for constructing phylogenetic trees. Recent advances in comparative genomics and proteomics are presented.
Prerequisite: BCH210H1/BCH242Y1, MGB311Y1/BIO349H1

BCH471Y1
Advanced Biochemistry Laboratory 168P

Experiments demonstrating modern concepts of biochemistry and molecular biology. (Enrolment limited)
Prerequisite: (BCH335H1 + 340H1 +371H1)/(CHM361[UTM] +362H[UTM]+371H[UTM]) + MGB311Y1

BCH473Y1
Special Work in Biochemistry 154P

Research in a particular area of biochemistry, by arrangement with the Department and the instructor concerned.
Prerequisite: BCH335H1 +340H1 + 371H1, and permission of Department
Co-requisite: BCH471Y1