Faculty of Arts & Science 2016-2017 Calendar

Laboratory Medicine and Pathobiology

• Pathobiology Specialist
• Laboratory Medicine and Pathobiology Courses

Faculty

The Department of Laboratory Medicine and Pathobiology provides a bridge between the basic sciences and medicine. Investigating the molecular mechanisms of disease is an important priority of the department. Faculty are concerned with the biochemical changes that may be associated with cell and tissue injury and with the etiology, pathogenesis and behaviour of disease. Research is carried out in such areas as cardiovascular disease, immunopathobiology, neuropathology, endocrinology and metabolism, neoplasia, bone and connective tissue disease, clinical and molecular epidemiology, antiobiotic resistance, and molecular pathogenesis of infectious disease.

The Pathobiology Specialist program gives students a broad understanding of contemporary medical research and basic scientific insights that have revolutionized our understanding of disease in recent years. Aspects of biochemistry, chemistry, cellular and molecular biology, and genetics are brought to bear upon human pathology. Graduates from the program will frequently pursue graduate studies in medical research and eventual research careers in academic, industrial, pharmaceutical, or governmental laboratories. A knowledge of cellular and molecular mechanisms of disease processes is also useful in a wide variety of multidisciplinary careers in government, regulatory agencies, law, and environment.

Undergraduate Secretary:  Prof. D.M. Templeton (doug.templeton@utoronto.ca)

Undergraduate Office/General inquiries: Teresa Trimboli, Medical Sciences Building, Rm. 6209, (416-946-7459; teresa.trimboli@utoronto.ca)

More information is available on our website:
http://www.lmp.utoronto.ca/

Course Coordinators:

LMP300Y1: Dr. D.M. Templeton (416-978-3972)
LMP301H1: Dr. L. Fu (416-323-6400 ext 4427) / Dr. P. Yip (416-340-4800)
LMP363H1: Dr. B. Bapat (416-586-4800)
LMP365H1: Dr. M. Ohh (416- 946-7922)
LMP402H1: Dr. M. Cybulsky (416-581-7483) / Dr. J. Mogridge (416-946-8095)
LMP403H1: Dr. O. Adeyi (416-340-3136) / Dr. H. Ni (416-864-6060 ext 6758)
LMP405Y1: Dr. H. Yeger (416-813-5958)
LMP406H1: Dr. M. Bendeck (416-946-7133)
LMP408H1: Dr. K. Mekhail (416-946-8132)
LMP410H1: Dr. J. Robertson (416-507-6875) / Dr. G. Schmitt-Ulms (416-507-6864)
LMP415H1: Dr. M. Pollanen (416-314-4040)
LMP436H1: Dr. S. Girardin (416-978-7507)

Laboratory Medicine and Pathobiology Programs

This is a limited enrolment program that can only accommodate a limited number of students. Eligibility will be competitive and based on a student’s marks in the 3.0 required first-year courses:

BIO120H1, BIO130H1, (CHM135H1, CHM136H1)/CHM151Y1; (MAT135H1, MAT136H1)/MAT137Y1/MAT157Y1.

Note:  Students must apply to this program on the Arts & Science Faculty Registrar’s Office website (see the Arts & Science Program Enrolment web site for application procedures) from early April to mid-May. At later times, contact the LMP Undergraduate Office.

(13.5 full courses or their equivalent, including at least two 400-series courses)
First Year:
(BIO120H1, BIO130H1); (CHM135H1, CHM136H1)/CHM151Y1; (MAT135H1, MAT136H1)/MAT137Y1/MAT157Y1
First or Second Year:
(PHY131H1, PHY132H1)/(PHY151H1, PHY152H1)
Second Year:
BCH210H1; BIO230H1; BIO260H1/HMB265H1; CHM220H1; CHM247H1/CHM249H1; PSL300H1; PSL301H1; STA220H1/BIO220H1
Third Year:
BCH370H1; BCH311H1/CSB349H1;(IMM340H1, IMM350H1)/(IMM341H1, IMM351H1)/(MGY377H1, MGY378H1); LMP300Y1; LMP365H1
Fourth Year:
At least 4 of LMP402H1, LMP403H1, LMP405Y1, LMP406H1, LMP408H1, LMP410H1, LMP415H1, LMP436H1 (Note: If the research project LMP405Y1 is taken, three additional courses from the list are still required.)

Laboratory Medicine and Pathobiology Courses

The 199Y1 and 199H1 seminars are designed to provide the opportunity to work closely with an instructor in a class of no more than twenty-four students. These interactive seminars are intended to stimulate the students’ curiosity and provide an opportunity to get to know a member of the professorial staff in a seminar environment during the first year of study. Details can be found at www.artsci.utoronto.ca/current/course/fyh-1/.

Credit course for supervised participation in faculty research project. Details at http://www.artsci.utoronto.ca/current/course/rop. Not eligible for CR/NCR option.

Concepts in pathogenesis; cell injury and death; tissue structure, wound healing; repair and fibrosis. Molecular basis of major organ system pathology. The laboratory examines gross anatomical specimens and introduces histopathology. Enrolment is limited to students specializing in pathobiology who have completed the first and second year requirements of the program.

Introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions. The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained. Not intended for students in the Pathobiology Specialist program.

Pathological changes brought on by foreign compounds; applications of pathology to the detection of toxic carcinogenic actions.

A general introduction to the cellular and molecular aspects of cancer and its etiology. The laboratory component presents the range of benign and malignant tumor types at the gross and histological levels. Pathophysiology of cancer, invasion and metastases, role of the immune system.

Mechanisms that allow microbial pathogens to cause disease and the host to detect infection, mount an inflammatory response and resolve the infection.  Primary research articles are discussed.  Topics include commensal bacteria, bacterial toxins, pattern recognition receptors, leukocyte emigration, chemotaxis, and the role of non-coding RNAs in immunity.

The immune system in disease. Responses of the immune system to host invasion, injurious stimuli, and transplantation. Immunopathology of organ-specific diseases including pancreas, gut, liver, heart, kidney, and blood. Intended for students specializing in pathobiology or related programs.

A self-contained research project to be completed under the supervision of a faculty member. The main areas of research are as listed in the description of the Department (above). The student will normally have completed three full years of study, and is expected to devote at least one full day per week to the project. Admission is by arrangement with the Department and with a particular supervisor. A list of potential supervisors is available from the Departmental Office and on our web site. Not eligible for CR/NCR option.

Pathobiology of the heart, blood vessels, and lymphatic system. Congenital diseases of the heart, ischemic injury, stroke. Treatments of vascular disease and cardiovascular biomaterials. Major focus on atherosclerosis and hypertension. The emphasis is on the underlying cell biology of these processes.

Introduces use of genetic model systems and organisms in exploring aspects of human reproduction, development, and disease. A major focus is on the impact of the genetic models on understanding  human health, and disease.  Ethical issues in animal research, genetic manipulation, and disease modeling are highlighted

Molecular basis of neurodegenerative diseases of the central and peripheral nervous systems. Relevant neuroanatomy and molecular biology of the CNS. Current research topics in neurodegenerative diseases.

A thematic review of the major scientific areas and research controversies in forensic medicine. The approach is mechanistic analysis and evidence-based medicine. Classical forensic medicine is critically analyzed with emphasis on experimental meth-ods to resolve controversies. We also explore how the justice system utilizes medical and scientific data.

Molecular mechanism involved in pathogenesis of infectious disease. Topics include recurrent themes in the establishment of infectious disease, such as adherence and spread of pathogenic bacteria as well as evasion of host defences. Emphasis is placed on genetic characterization and expression of virulence determinants and on interactions between bacterial pathogens and their hosts.