Cell and Systems Biology Courses

For Distribution Requirement purposes, all BIO and CSB courses are classified as SCIENCE courses.

| Course Winter Timetable |

Molecular Biology [24L, 15P]

An introduction to the structures and functions of DNA, RNA and proteins, exploring how the molecular information contained within an organism’s genome is converted into cellular function. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques.

Exclusion: BIO250Y1, BIO255Y1
Prerequisite: BIO150Y1, (CHM138H1, CHM139H1)/CHM151Y1
Recommended preparation: BCH210H1 (taken concurrently or previously)

Cell and Developmental Biology [24L, 15P]

An introduction to the structure and function of cells focusing on the molecular basis of cell and developmental biology. Lecture topics include membrane transport, protein sorting and cell communication plus cellular architecture and the formation of tissues. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques.

Exclusion: BIO250Y1, BIO255Y1
Prerequisite: BIO240H1
Recommended preparation: BCH210H1 (taken concurrently or previously)

Cell and Molecular Biology with Advanced Laboratory [48L, 36P]

An introduction to the structure and function of cells at the molecular level: key cellular macromolecules; transfer of genetic information; cell structure and function; cellular movement and division. The Enhanced Laboratory provides the opportunity for greater laboratory skill development in modern investigative techniques and is intended for students interested in conducting their own laboratory research.

Exclusion: BIO240H1, BIO241H1, 250Y1
Prerequisite: BIO150Y1, (CHM138H1, CHM139H1)/CHM151Y1, cGPA 3.0
Recommended preparation: BCH210H1 (taken concurrently or previously)

Concepts in Genetics [36L, 12T]

This is a problem based course which discusses classical, molecular, developmental, and population genetics and genomics with emphasis on model organisms for genetic analysis.

Exclusion: HMB265H1
Prerequisite: BIO240H1
Co-requisite: BIO241H11/BIO255Y1

Animal Physiology I [24L, 9P]

The main ideas of physiology and the contribution of experimentation to our understanding of life processes. Uses examples from throughout the animal kingdom, and includes the physiology of homeostasis and the endocrine system. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques.

Exclusion: BIO/ZOO252Y1
Prerequisite: BIO150Y1

Animal Physiology II [24L, 9P]

The main ideas of physiology and the contribution of experimentation to our understanding of life processes. Uses examples from throughout the animal kingdom, and includes the physiology of the nervous and cardiorespiratory systems. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques.

Exclusion: BIO/ZOO252Y1
Prerequisite: BIO270H1

Current Topics in Molecular Biology [48L, 24P]

This course is intended to provide non-science students with an understanding of basic concepts in molecular biology to allow them to explore, and analyze current scientific issues and controversies covered in the media and relevant to society at large.
This course counts as a Science Distribution Requirement for students in all years and disciplines; particularly suitable for Humanities and Social Science students.

Exclusion: (BIO240H1, BIO241H1)/250Y1/BIO255Y1

Research Opportunity Program

Credit course for supervised participation in faculty research project. Details here.

Endocrine Physiology (formerly ZOO325H1) [24L]

The regulation of physiological processes by hormones and other signalling molecules in chordates. An integrated genes-to-environment approach is used to examine aspects of hormonal evolution, physiological information flow, behaviour and neuroendocrinology, and xenobiotic endocrine disruptors.

Exclusion: ZOO325H1
Prerequisite: (BIO270H1, BIO271H1)/PSL302Y1
Recommended preparation: EEB265Y1

Extracellular Matrix Biology and Associated Pathologies (formerly ZOO327H1) [36L]

Examines expression, structure and function of the four major classes of ECM macromolecules: collagen, proteoglycans, non-collagenous structural proteins and glycoproteins. In addition to forming elaborate networks that give tissues and organs their unique architectural design and biophysical properties, ECM molecules act as potent regulators of all cellular activities. Emphasis is placed on
the morphoregulatory contribution(s) of ECM molecules to normal and pathological development.

Exclusion: ZOO327H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1

Developmental Biology (formerly ZOO328H1) [24L, 24T]

Basic concepts in developmental biology. Early development of invertebrates and vertebrates will be discussed with emphasis on experimental and molecular analysis of developmental mechanisms. Tutorials demonstrate examples of descriptive and experimental embryology and discuss primary literature of selected topics in developmental biology.

Exclusion: ZOO328H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, BIO260H1/HMB265H1

Techniques in Molecular, Cellular and Developmental Biology (formerly ZOO330H1) [12L, 36P]

A laboratory based course in current research techniques, employing animal model organisms (fruit fly and zebrafish) and experimental methods including basic molecular and cell biology techniques.

Exclusion: MGY432H1, ZOO330H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, BIO260H1/HMB265H1, CSB328H1

Advanced Cell Biology I: Cell Adhesion and Migration (formerly ZOO331H1) [36L]

The development of multicellular organisms is dependent on a broad variety of different cell-cell and cell-matrix adhesive mechanisms. The course examines the molecules and mechanisms involved and how they act in concert to regulate distinct developmental and physiological events. Emphasis is placed on the experimental approaches and technology used to study the molecular interactions and dynamics and alter structure-function relationships in cells and organisms.

Exclusion: BCH304H1, ZOO331H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1

Neurobiology of the Synapse (formerly ZOO332H1) [24L]

Examination of all aspects of the synapse in both the peripheral and central nervous systems of invertebrates and vertebrates. Topics include: synapse formation, synaptic transmission, synaptic plasticity, learning and memory, and neurological disorders.

Exclusion: ZOO332H1
Prerequisite: (BIO270H1, BIO271H1)/PSL201Y1/PSL302Y1

Plant Development (formerly BOT340H1) [24L]

Plant developmental genetics at the molecular, cellular and organismal level, generation and use of genomic resourses in plant model organisms. Questions address the genetic dissection of plant embryo and meristem development, plant stem cell specification and tissue patterning. Genomic approaches applicable to plant biotechnology are also covered.

Exclusion: BOT340H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, BIO260H1/(HMB265H1 with a minimum grade of 73%)

Animal Energetics [24L, 12T]

Animal structure and function, at all levels from molecule to whole animal, are dependent on energy. This course describes how the supply, consumption, transformation, exchange and storage of energy can facilitate, constrain and limit animal function. Emphasis is placed on systems level physiological function and whole animal performance.
Prerequisite: BIO252Y1/(BIO270H1, BIO271H1)/PSL201Y1/PSL302Y1
Recommended preparation: BCH210H1/BCH242Y1

Neurobiology of Respiration (formerly ZOO346H1) [24L, 12T]

Integrated control of cardio-respiratory physiology and metabolism in mammals. Topics include exercise, diving, sleep and hibernation.

Exclusion: ZOO346H1
Prerequisite: (BIO270H1, BIO271H1)/ PSL302Y1

Comparative Cellular Physiology (formerly ZOO347H1) [24L]

In-depth survey of unique cellular adaptations of different tissues and organisms to overcome environmental stresses such as hypoxia. Emphasis is placed on cellular strategies, particularly second messenger responses, although systematic and whole organism responses will be investigated. Broad-ranging common strategies among diverse organisms are examined.

Exclusion: ZOO347H1
Prerequisite: (BIO270H1, BIO271H1)/PSL302Y1

Eukaryotic Gene Expression (formerly BIO349H1) [26L, 18T]

Genome structure and the regulation of gene expression in eukaryotic cells. Topics include gene duplication, repetitive DNA, transcription, RNA interference and expression profiling. Tutorials emphasize problem based learning exercises that relate to recent advances in the broad field of eukaryotic gene expression.

Exclusion: BIO349H1, BCH311H1, MGY311Y1, MGY420H1, PSL350H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, BIO260H1/HMB265H1
Recommended preparation: BCH210H1/320Y1

Laboratory in Molecular Plant Biology (formerly BOT350H1) [24L, 36P]

Laboratory methods used in plant molecular biology research. Topics include vector construction, plant transformations, PCR, DNA blots, high-throughput screens, genetic mapping, and bioinformatic analyses.

Exclusion: BOT350H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, BIO260H1/HMB265H1
Recommended preparation: BIO251Y1 or higher level plant biology course; BCH311H1/CSB349H1/MGY311Y1 concurrently

Introductory Virology (formerly BIO351Y1) [48L, 96T]

An introduction to basic and medical virology. Attendance in tutorials is optional.

Exclusion: BIO351Y1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1

Bioinformatic Methods (formerly BIO352H1) [24L]

Use of available programs for analyzing biological data. This is an introductory course with a strong emphasis on hands-on methods meant for Biology and Human Biology/GGB specialists/majors. Some theory is introduced, but the main focus is on using extant bioinformatics tools to analyze data and generate biological hypotheses.

Exclusion: BIO352H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, BIO260H1/HMB265H1

Introduction to Plant-Microbe Interactions (formerly BOT351H1) [24L]

Plants have co-evolved with microbes ever since their first appearance on land, resulting in sophisticated strategies of pathogenicity, symbiosis, commensalisms and mutualism. This course presents an overview of these strategies with examples of bacteria, fungi, oomycetes and viruses that have evolved intimate associations with plants, and discusses plant immune systems.

Exclusion: BOT351H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1
Recommended preparation: BIO251Y1

Independent Experiential Study Project

Independent Experiential Study Project

An instructor-supervised group project in an off-campus setting. Details here.

400-Series Courses

Endocrinology of Transformation (formerly ZOO425H1) [24L, 12T]

The student will investigate the endocrine and paracrine signalling mechanisms that act to coordinate the reorganization of tissues in animals in special situations. The topics covered will include metamorphosis in agnathans and amphibians, sex change in teleost fishes, limb and regeneration in reptiles and amphibians, and neural regeneration in birds and mammals.

Exclusion: ZOO425H1
Prerequisite: CSB325H1/PSL424H1; CGPA 2.7

Plant Cells and Their Uses [24L]

This course will consider some of the polymers and smaller molecules produced by plants, including their biosynthesis, their involvement in plant growth and survival, and their use by humans. The course will have a strong biochemistry, genetics and molecular biology emphasis, and an applied component, examining human uses of plants.
Prerequisite: (BIO240H1, BIO241H1)/BIO255Y1/CHE354H1
Recommended preparation: BIO260H1/HMB265H1, CSB350H1/CSB459H1

Advanced Cell Biology II: Cell Polarity and Cytoskeletal Dynamics [12L, 12S, 12T]

This advanced course covers cell polarity and cytoskeletal dynamics emphasizing current literature. For each topic, the course examines (1) the proteins involved, (2) their interactions and regulation, and (3) how they organize specific cellular structures. The coordination of these
complexes required for orchestrating complex cellular processes are addressed.
Prerequisite: BCH311H1/CSB349H1/MGY311Y1, BCH304H1/CSB328H1/CSB331H1/CSB340H1, cGPA 2.7

Germ Cell Biology (formerly ZOO429H1) [12L, 12S, 12T]

This course will discuss the genetic and cell biological aspects of the development of gametes, gonads, and sex related traits in animals, including invertebrates and vertebrates. In the accompanying seminar, primary literature is used to discuss selected topics in germ cell biology.

Exclusion: ZOO429H1
Prerequisite: CSB328H1/329H1/CSB340H1/CSB349H1/MGY311Y1/MGY312H1, cGPA 2.7

Developmental Neurobiology (formerly ZOO430H1) [24L, 12T]

An examination of the molecular genetic basis of nervous system formation. Experimental evidence from recent studies in selected invertebrate and vertebrate model systems will be discussed. Topics include the evolution of neural development, neural cell fate determination, neurogenesis, pattern formation, and axon guidance.

Exclusion: ZOO430H1
Prerequisite: CSB328H1/(NRS201H1/HMB204H1/PSY290H1, NRS202H1/HMB320H1)

Evolution of Development (formerly CSB329H1) [24L, 24T]

This course begins with a comparison of embryonic development in the major animal taxa. The evolution of developmental mechanisms is then considered with emphasis on the molecular and genetic basis of these mechanisms. Subsequent discussion examines the impact of developmental processes on the evolution of animal diversity. Tutorials feature the study of embryos representing diverse animal taxa.

Exclusion: CSB329H1, ZOO329H1
Prerequisite: CSB328H1/((BIO240H1, BIO241H1)/250Y1/BIO255Y1, BIO260H1/HMB265H1 and permission of instructor)
Recommended preparation: CSB328H1

Regulatory Networks and Systems in Molecular Biology [24L]

This course will expose students to several of the best-understood regulatory networks in molecular biology, as well as recent technological and methodological developments. Emphasis is on the mechanistic basis for these systems, methods and models for quantitative analysis of regulatory networks, and the biological logic they encode.
Prerequisite: BCH311H1/CSB349H1/MGY311Y1

Biology of Sleep (formerly CSB345H1) [6L, 18S]

Covers theories on the biological function of sleep-wake states – why and how animals sleep. Integrates all levels of organization, including molecular biology, homeostasis, bioenergetics, neurophysiology, endocrinology, behaviour and evolution, with comparisons across phyla. This course emphasizes student participation in seminar discussion and debates.

Exclusion: CSB/ZOO345H1
Prerequisite: BIO252Y1/(BIO270H1, BIO271H1)/PSL302Y1
Recommended preparation: CSB332H1/PSY397H1

Plant Proteomics in Systems Biology (formerly BOT450H1) [24L]

This course introduces students to proteomics and metabolomics approaches, such as mass spectrometry, structural biology, 2D gel electrophoresis, in understanding the regulation of metabolic pathways in plants.

Exclusion: BOT450H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, BCH210H1

Molecular Plant-Microorganism Interactions (formerly BOT452H1) [24L]

This course explores the molecular strategies that microbes and plants have evolved to live with each other. The variety of strategies will be summarized with emphasis on the molecular mechanisms of pathogenic relationships.

Exclusion: BOT452H1
Prerequisite: BCH311H1/CSB349H1/MGY311Y1
Recommended preparation: CSB353H1

Epigenetics (formerly BIO458H1) [36S]

A seminar course exploring non-Mendelian phenomena in plants, fungi and animals that reveal aspects of genome organization and regulation that may provide insight into genome function and evolution.

Exclusion: BIO458H1
Prerequisite: BIO260H1/HMB265H1, BCH311H1/CSB349H1/MGY311Y1
Recommended preparation: HMB321H1

Plant Molecular Biology and Biotechnology (formerly BOT458H1) [24L]

This course introduces students to major features of gene expression and signal transduction in plants. Topics include strategies for generating transgenic plants and regulating gene expression, as well as the importance of signal transduction in plant growth and survival. How plants sense and respond at the molecular level to environmental stresses such as drought, salinity, cold and disease will be discussed. The application of this basic scientific information in biotechnological strategies for improving agronomic traits will also be addressed.

Exclusion: BOT458H1
Prerequisite: BCH311H1/CSB349H1/MGY311Y1

Plant Signal Transduction (formerly MGY460H1) [24L]

Plant development, ecological adaptation and crop plant productivity depend on the sophisticated potential of plants to sense and compute signals to regulate their responses. An arsenal of genetic and genomic tools is employed to elucidate these plant signal transduction pathways. Examples from the original literature will be used to introduce general concepts of plant signal transduction, molecular biology and genomics and their application in understanding and influencing plant growth and development.

Exclusion: MGY460H1
Prerequisite: BCH311H1/321Y1/CSB349H1/MGY311Y1 or permission of instructor

Computational Genomics and Bioinformatics (formerly BIO472H1) [24L, 12T]

Computational analyses of DNA and RNA expression data. Understanding biological databases, sequence alignment, sequence annotation, gene prediction, computational analysis of function, motif analysis, phylogenetic analysis, and microarray analysis. Applied, theoretical and statistical issues will be addressed.

Exclusion: BCH441H1, BIO472H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1
Recommended preparation: BIO260H1/HMB265H1

Chemical Genomics (formerly BIO473H1) [24L]

This course surveys the field of Chemical Genomics, focusing on the analysis of biological problems using chemical approaches. Topics covered include chemical genetics, combinatorial chemistry and combinatorial strategies in molecular biology. Examines both the underlying biological and chemical concepts; however, the focus is primarily biological.

Exclusion: BIO473H1
Prerequisite: (BIO240H1, BIO241H1)/250Y1/BIO255Y1, CHM247H1
Recommended Preparation: BCH210H1, BIO260H1/HMB265H1

Methods in Genomics and Proteomics [60P]

This three-week summer course is a hands-on, laboratory based course, offered through the Centre for the Analysis of Genome Evolution and Function (CAGEF), will teach students how to produce and analyze data that are central to the fields of genomics and proteomics. Techniques taught include DNA and RNA extraction, PCR, DNA sequencing, quantitative PCR, transcript profiling using microarrays, 2D-gel proteome analysis, and associated bioinformatics analyses.
Prerequisite: BIO260H1/HMB265H1, BIO255Y1/CSB330H1/CSB350H1 or by permission of the instructor
Recommended Preparation: BCH311H1/CSB349H1/MGY311Y1

Plant Metabolomics [24L]

This course introduces students to major features of plant metabolism. The content covers plant physiology, natural product chemistry, genetics, molecular biology, and genomics. Topics also include strategies for designing how we modulate metabolic pathways and how we utilize plants for biotechnology through metabolic engineering.
Prerequisite: BCH311H1/CSB349H1/MGY311Y1

Seminar in Development I [24S]

Seminars analyzing the major problems in developmental biology from cellular, genetic and molecular perspectives.

Exclusion: BIO482Y1, CSB482Y1
Prerequisite: CSB328H1/CSB340H1

Seminar in Development II [24S]

Students will choose a major issue in contemporary Developmental Biology and critically analyze present and future prospects in that field.

Exclusion: BIO482Y1, CSB482Y1
Prerequisite: CSB483H1

Project in Cell and Systems Biology I (formerly ZOO498Y1) [TBA]

Project in Cell and Systems Biology I (formerly ZOO498Y1) [TBA]

An original research project (a literature review alone is not sufficient) requiring the prior consent of a member of the Department to supervise the project. The topic is to be one mutually agreed on by the student and supervisor. They must arrange the time, place, and provision of any materials and submit to the Undergraduate Office a signed form of agreement outlining details prior to being enrolled. This course is normally open only to Fourth Year students with adequate background in Cell and Systems Biology. All students are required to make written and, perhaps, oral presentations of the results of their projects and participate in a poster session. A copy of a written report must be submitted to the Undergraduate Office.

Exclusion: BOT460Y1/461H1/462Y1/463H1/ZOO498Y1/499Y1

Project in Cell and Systems Biology II (formerly ZOO499Y1) [TBA]

Allows students to do a second independent project, supervision of which must be different from CSB497H1/CSB498Y1. Operates in the same manner as CSB497H1/CSB498Y1.

Exclusion: BOT462Y1/463H1/ZOO499Y1
Prerequisites: CSB497H1/CSB498Y1