PSL201Y1
Basic Human Physiology 52L
A survey course intended for students who are not proceeding further in Physiology.
Exclusion: Any PSL course taken previously or concurrently
Prerequisite: 100-level course in BIO
PSL299Y1
Research Opportunity Program
Credit course for supervised participation in faculty research project. See page 43 for details.
PSL300H1
Human Physiology I 39L, 5T
Principles of neurophysiology and endocrinology for students enroled in the Neuroscience program.
Exclusion: PSL201Y1, PSY391H1
Prerequisite: BIO150Y1; CHM138H1; PHY100-series
PSL301H1
Human Physiology II 39L, 4T
Principles of respiratory, cardiovascular, gastrointestinal, renal and reproductive physiology for students enroled in the
Neuroscience program.
Exclusion: PSL201Y1
Prerequisite: BIO150Y1; CHM138H1; PSL300H1
JBO302Y1
Human Physiology and Biophysics 78L, 12T
Principles of Human Physiology with tutorials on the biophysical concepts applied to physiological processes. Restricted to
students enroled in the Biophysics and Physiology (Theoretical) programs
Exclusion: PSL201Y1, PSL302Y1
Prerequisite: BIO150Y1; CHM138H1; MAT135Y1/MAT137Y1; PHY138Y1/PHY140Y1
PSL302Y1
Human Physiology 78L, 9T
Principles of Human Physiology for students enroled in Basic Medical Science programs.
Exclusion: PSL201Y1
Prerequisite: BIO150Y1, CHM138H1; MAT100-series/PHY100-series
PSL303Y1
Topics in Cellular, Molecular and Organismic Physiology 78L,
26T
Using homeostasis and feedback as a unifying theme, topics in control systems, cell signalling, rhythms, environmental
adaptations and body weight regulations are examined. Tutorials use computer simulations and problem sets.
Prerequisite: JBO302Y1/PSL302Y1/ZOO252Y1, MAT 100-series, PHY 100-series
Co-requisite: PSL372H1, PSL374H1 or permission of Department
PSL350H1
Mammalian Molecular Biology 20L, 6S
Molecular biology is essential for understanding mammalian function. The knowledge from BIO250Y1 of DNA, RNA, and protein
is extended to current, primary literature on mammalian molecular biology. Application of molecular biology to disease and to
complex behaviors is followed by small group sessions on topics with a bioethics component.
Prerequisite: BIO250Y1
Exclusion: BIO349H1/JLM349H1/MGY311Y1
Recommended Preparation: PSL300H1/PSL301H1/PSL302Y1/ JBO302Y1/BCH210H1
PSL372H1
Mammalian Physiology Laboratory 13L, 39P
A laboratory course covering selected topics in physiology.
Prerequisite: BIO250Y1, BCH210H1, MAT 100-series, PHY 100-series
Pre- or co-requisite: PSL302Y1, BCH370H1 (recommended)
PSL374H1
Advanced Physiology Laboratory 13L, 13S, 39P
A problem-based laboratory course focussed on the integration of organ systems to understand the control mechanisms of
body function.
Prerequisite: BIO250Y1, PSL302Y1/ZOO252Y1, PSL372H1
Co-requisite: BCH370H1
PSL420H1
Reproduction I: Development and Function 26L
This course provides an in-depth review of the development and function of the male and female reproductive systems. Topics
include sex determination and differentiation, gametogenesis, hormonal control of the reproductive systems, the female
ovulatory cycle, seasonal breeding, sexual behaviour, fertilization and implantation.
Prerequisite: PSL302Y1
PSL421H1
Reproduction II: Pregnancy and Birth 26L
General overview of the integrated physiologic events associated with pregnancy and birth. The approach emphasizes
physiologic processes using insights gained from studies of humans, animals, cells and genes. Where appropriate the clinical
consequences of aberrant development are reviewed.
Prerequisite: PSL302Y1
Recommended Preparation: PSL420H1
PSL425H1
Integrative Metabolism and its Endocrine Regulation 26L
This course integrates the newest findings and experimental approaches from cellular and molecular biology into metabolic
function at the tissue, organ and whole body level.
Prerequisite: BCH210H1, PSL302Y1
Recommended Preparation: PSL303Y1
PSL432H1
Theoretical Physiology 26L
Theoretical treatment of neurophysiology. Mathematical modelling and analysis of neurophysiological systems.
Prerequisite: MAT235Y1/MAT237Y1; APM346H1/MAT244H1
Recommended Preparation: PHY200-series; PSL201Y1/PSL302Y1/ ZOO252Y1
PSL440Y1
Neuroscience I: Systems and Behaviour 78L
Introduction to systems neuroscience. A review of basic neuroanatomy and physiology followed by in-depth study of selected
sensory and motor systems. Students with an elementary neuroscience background progress to reading neuroscience
literature on their own.
Prerequisite: PSL300H1/PSL302Y1/PSY290H1/ZOO332H1 or equivalent
PSL443H1
Motor Control Systems 26L
Control of body movement and posture by the nervous system in normal and pathological conditions. Topics include nonlinear
dynamical systems, central pattern generators in the cerebral cortex, brainstem and spinal cord, reflexes, and basal ganglia-
cerebellar function.
Prerequisite: PSL300H1/PSL302Y1
PSL444Y1
Neuroscience II: Cellular and Molecular 78L
Overview of the fundamentals of cellular and molecular aspects of brain function. Course material is updated yearly to reflect
the rapid evolution of ideas in Neuroscience.
Prerequisite: PSL300H1/PSL302Y1/ZOO332H1
PSL452H1
Membrane Physiology 26L
Biophysics and molecular biology of ion channels. Topics include equivalent circuits for cells, molecular structure of voltage-
gated channels, distribution of channels, relationship between single-channel and whole-cell recording and regulation of
channel function by voltage, phosphorylation, G-proteins and metabolites.
Prerequisite: PSL303Y1
Recommended Preparation: PSL431H1, PSL432H1
PSL454H1
Physiological Instrumentation and Electronics 13L, 39P
A practical approach to instrumentation as a preparation for using sophisticated measurement systems.
Prerequisite: PHY138Y1 or equivalent
PSL460H1
Molecular Physiology 26L, 4S
An overview of the ways in which techniques in molecular biology are being used to resolve current issues in physiology. The
systems to be studied include individual cells, organ systems, integrated systems, and whole animal physiology and
pathophysiology.
Prerequisite: BCH210H1, BIO250Y1, BIO349H1/PSL350H1, PSL302Y1
PSL462H1
Molecular Aspects of Cardiovascular Function 26L
Heart anatomy and development, ion channels and contractile proteins involved in cardiac and smooth muscle contraction are
studied. Emphasis is on regulation of electrical and contractile function of kinases, metabolism, volume and ions.
Prerequisite: PSL303Y1
PSL470H1
Cardiovascular Physiology 26L, 13T
Development of the cardiovascular system from conception to adulthood with particular emphasis on maturational changes,
age-related differences and developmental problems from cellular/molecular to whole organ/system.
Prerequisite: PSL302Y1
PSL472H1
Sleep Physiology and Chronobiology 26L
An in-depth analysis of the basic physiology underlying sleep and circadian rhythms, and of their impact on important
physiological processes, of which effects on cardio-respiratory systems are emphasized.
Prerequisite: PSL302Y1
PSL497H1
Scientific Communication 26L/ST
Students learn to read, write and speak about current research in Physiology.
Prerequisite: PSL302Y1
PSL498Y1/499H1
Project in Physiology 156P/78P
Laboratory research project with reading assignments leading to a final report. By special arrangement with a Physiology staff
member after admission to course. PSL498Y1 is recommended for students applying to the Physiology graduate program.
Prerequisite: PSL303Y1, PSL372H1, PSL374H1, permission of Department
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