MGY299Y1
Research Opportunity Program
Credit course for supervised participation in faculty research project. See page 43 for details.
MGY311Y1
Molecular Biology 78L
(formerly MGB311Y1)
DNA replication, DNA repair and mutation, recombination, transcription, RNA modification and processing, the genetic code
and tRNA, translation, regulation of gene expression, development and differentiation, molecular evolution.
Exclusion: BIO349H1, JBC372H5(UTM), MGB311Y1, PSL350H1
Prerequisite: BIO250Y1, BCH242Y1
MGY312H1
Principles of Genetic Analysis 78P
(formerly MGB312H1)
Laboratory experiments in genetics of selected organisms. Topics studied include Mendelian genetics, linkage and
recombination, complementation, analysis of chromosome rearrangements, mutant selection and analysis in plants and
bacteria, and genetic crosses with plants, bacteria and bacteriophages.
Exclusion: MGB312H1
Prerequisite: BIO250Y1, BIO260H1
Co-requisite: MGY311Y1
MGY376H1
Microbiology Laboratory 78P
(formerly MBY376H1)
Fundamental laboratory techniques in bacteriology and virology. Valuable not only for students specializing in Microbiology but
also for those in related disciplines which make use of bacteria and viruses as research tools. Open to students in related
programs.
Exclusion: MBY376H1
Prerequisite: BIO250Y1, BIO260H1/HMB265H1
Co-requisite: MGY377H1, MGY378H1
MGY377H1
Microbiology I: Bacteria 39L
(formerly MBY377H1)
Detailed study of bacteria in terms of structure, classification and replication. Basis for advanced study in various aspects of
bacteriology including bacterial physiology, bacterial genetics, molecular pathogenesis of disease and environmental studies.
Exclusion: MBY375Y1, MBY377H1
Prerequisite: BCH210H1/BCH242Y1; BIO250Y1
MGY378H1
Microbiology II: Viruses 39L
(formerly MBY378H1)
Detailed study of viruses in terms of structure, classification, replication and interaction with the host. Basis for advanced study
in virology. Requires some familiarity with immunology. A concurrent course in immunology (IMM334Y1/IMM335Y1) is
recommended.
Exclusion: BIO351Y1, MBY375Y1, MBY378H1
Prerequisite: BCH210H1/BCH242Y1; BIO250Y1; BIO260H1/HMB265H1
Co-requisite: BIO349H1/MGY311Y1
Recommended preparation: MGY377H1
MGY420H1
Regulation of Gene Expression 26L
(formerly MGB420H1)
This course describes regulatory mechanisms controlling gene expression in prokaryotes and eukaryotes. The lectures are
designed to promote discussion of various experimental approaches. Topics include: assembly of a transcription complex;
initiation of transcription; role of sigma factors and transcription factors; role of regulators of transcription; regulation of SV40
transcription; lambda antitermination; antitermination in HIV-1.
Exclusion: BIO477H5 (UTM), MGB420H1
Prerequisite (2005-2006): BCH242Y1, MGB311Y1/MGY311Y1
Prerequisite (2006 onwards): BCH242Y1, BCH340H1, MGB311Y1/MGY311Y1
MGY425H1
Signal Transduction and Cell Cycle Regulation 26L
(formerly MGB425H1)
This course presents and integrates molecular aspects of signal transduction and cell cycle regulation in eukaryotic cells from
yeast to humans. Emphasis is on recent advances in growth factor receptor signalling, modular protein domains, and the
recurrent role of protein phosphorylation and protein-protein interactions in cell regulation.
Exclusion: MGB425H1
Prerequisite: BCH242Y1, MGB311Y1/MGY311Y1
MGY428H1
Functional and Microbial Genomics 26L
A broad ranging course that covers many aspects of genomics, which is the discipline of defining and attributing function to all
of the heritable material of an organism on a genome-wide scale, as applied to microbes, invertebrates and vertebrates. The
primary and review literature will be the basis of all lectures.
Exclusion: MBY428H1
Prerequisites: BCH210H1/BCH242Y1; BIO260H1/HMB265H1; MGY311Y1/BIO349H1
MGY432H1
Laboratory in Molecular Genetics and Microbiology 78P
Laboratory experiments demonstrating basic and advanced molecular biological methods applied to molecular genetics and
microbiology.
Exclusion: MGB430H1, MBY450H1, ZOO330H1
Prerequisite: MGY312H1/MGY376H1
Note: MGY432H1 will fulfill the course requirement for the former MGB430H1 or MBY450H1
MGY434H1
Bacterial Signalling and Physiological Regulation 39L
(formerly MBY434H1)
How bacteria sense their environment and signal to regulatory systems when to adapt to environmental stimuli. Topics
discussed include the bacterial cell cycle, carbon/energy metabolism, catabolite repression, bacterial development, sporulation,
stress responses, regulatory two-component systems and quorum sensing.
Exclusion: MBY434H1
Prerequisite: BCH210H1/BCH242Y1, MBY377H1/MGY377H1, BIO349H1/MGB311Y1/MGY311Y1
MGY440H1
Molecular Virology 39L
(formerly MBY440H1)
Analysis of virus/host interactions at the molecular level. Course material is based on recent research publications.
Exclusion: MBY440H1
Prerequisite: BCH210H1/BCH242Y1; BIO349H1/MGB311Y1/ MGY311Y1; MBY378H1/MGY378H1. (Note: BIO351Y1 is
not an
acceptable equivalent to MGY378H1)
Recommended preparation: IMM334Y1/IMM335Y1
MGY445H1
Genetic Engineering for Prevention and Treatment of Disease 39L
(formerly MBY445H1)
Current approaches to gene therapy including design of virus-based vectors for delivery and expression of effector genes.
Emphasis on the use of retrovirus-based strategies for prevention and treatment of HIV infection.
Exclusion: MBY445H1
Prerequisite: MBY378H1/MGY378H1/MGB311Y1/MGY311Y1
MGY451H1
Genetic Analysis of Development: Yeast and Worms 26L
(formerly MGB451H1)
Basic and advanced principles of genetic analysis applied to the study of two of the best-understood eukaryotic model
organisms: the yeast Saccharomyces cerevisiae, and the nematode worm Caenorhabditis elegans. We emphasize the use of
genetic approaches to address problems in cell biology and development, such as the regulation of cell fate. Much of the
knowledge gained from these simple organisms has proven broadly applicable, and the same principles of developmental
genetic analysis underlie efforts to understand the development of more complex organisms.
Exclusion: MGB451H1
Prerequisite: BIO260H1, MGB311Y1/MGY311Y1/BIO349H1
MGY452H1
Genetic Analysis of Development: Flies and Mice 26L
(formerly MGB452H1)
This is a companion course to MGY451H1. Advanced genetic principles and approaches, used in the study of fly and mouse
development, are introduced. Emphasis is placed on developmental processes that are conserved among these major model
organisms.
Exclusion: MGB452H1
Prerequisite: BIO260H1, MGB311Y1/MGY311Y1/BIO349H1
Recommended preparation: MGY451H1 or equivalent
MGY460H1
Plant Molecular Genetics 26L
(formerly MGB460H1)
Structure, organization, expression and regulation of genes in the nucleus, and chloroplast of photosynthetic organisms;
regulation of gene expression during plant development and in response to the environment.
Exclusion: MGB460H1
Prerequisite: BCH321Y1/MGB311Y1/MGY311Y1/BIO349H1 or permission of instructor
MGY470H1
Human and Molecular Genetics 26L
(formerly MGB470H1)
Current aspects of human and molecular genetics including: chromosome structure and function, inheritance of mutations and
disease, the human genome and disease gene mapping, cancer genetics, mouse disease models and gene based diagnostics
and therapies.
Exclusion: MGB470H1
Prerequisite: MGB311Y1/MGY311Y1
MGY480Y1
Special Project TBA
(formerly MGB480Y1/MBY422Y1)
An opportunity for specialized individual research in molecular genetics and microbiology by arrangement with the course
coordinator.
Exclusion: MGB480Y1, MBY422Y1
Co-requisite: MGY432H1
MGY485H1
Vaccines and Vaccination 39L
(formerly MBY480H1)
Analysis of infectious disease vaccines; past, present and future, with an emphasis on molecular aspects. Special topics
include: molecular basis of pathogenicity; vaccination strategies; genetically engineered vaccines; DNA vaccines; modulation
of the immune response by vaccine adjuvants; adverse effects of vaccines.
Exclusion: MBY480H1
Prerequisite: MBY377H1, 378H1/MGY377H1, MGY378H1
Recommended preparation: IMM334Y1/IMM335Y1
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