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LMP Laboratory Medicine and Pathobiology Courses LMP299Y1
LMP300Y1 Concepts in pathogenesis; cell injury and death; tissue
structure, wound healing; repair and fibrosis. Molecular basis of major organ system
pathology. The laboratory examines gross anatomical specimens and introduces
histopathology. Enrolment is limited to students specializing in pathobiology who have
completed the first and second year requirements of the program. LMP301H1 Introduces concepts and mechanisms of disease processes as
they arise from disturbances of normal biochemical and physiological functions. The
rational use of the clinical biochemistry laboratory in the diagnosis and management of
disease is explained. Not intended for students in the Pathobiology Specialist program. LMP363H1 Pathological changes brought on by foreign compounds;
applications of pathology to the detection of toxic carcinogenic actions. LMP365H1 A general introduction to the cellular and molecular aspects
of cancer and its etiology. The laboratory component presents the range of benign and
malignant tumor types at the gross and histological levels. Pathophysiology of cancer,
invasion and metastases, role of the immune system. LMP402H1 Cellular and molecular components of the inflammatory
response. Activation of the inflammatory response by viral and microbial pathogens. Tissue
pathology resulting from the inflammatory response. Evolution of pathogens to avoid and
exploit the response. (First offered in Fall 2002) LMP403H1 The immune system in disease. Responses of the immune system
to host invasion, injurious stimuli, and transplantation. Immunopathology of
organ-specific diseases including pancreas, gut, liver, heart, kidney, and blood. Intended
for students specializing in pathobiology or related programs. (First offered in 2002-03) LMP404H1 Focused broadly on the theme of calcium, from its cellular
function and the endocrine systems regulating it, to bone structure and biomechanics.
Selected bone diseases, their genetic variability, and treatment strategies are considered
in depth. (First offered in Fall 2002) LMP405Y1 A self-contained research project to be completed under the
supervision of a faculty member. The main areas of research are as listed in the
description of the Department (above). The student will normally have completed three full
years of study, and is expected to devote at least one full day per week to the project.
Admission is by arrangement with the Department and with a particular supervisor. A list
of potential supervisors is available from the Departmental Office and on our web site. LMP406H1 Pathobiology of the heart, blood vessels, and lymphatic
system. Congenital diseases of the heart, ischemic injury, stroke. Treatments of vascular
disease and cardiovascular biomaterials. Major focus on atherosclerosis and hypertension.
The emphasis is on the underlying cell biology of these processes. (First offered in
2002-03) LMP436H1 Molecular mechanism involved in pathogenesis of infectious
disease. Topics include recurrent themes in the establishment of infectious disease, such
as adherence and spread of pathogenic bacteria as well as evasion of host defences.
Emphasis is placed on genetic characterization and expression of virulence determinants
and on interactions between bacterial pathogens and their hosts. |
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