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BCH Biochemistry Courses BCH299Y1
BCH210H1 An introductory course in biochemistry covering proteins,
enzymes, and metabolism. This course is intended for students who are NOT taking BCH242Y as part of their program. BCH242Y1 An introduction to biochemistry for students specializing in
biochemistry and related specialist programs. The major topics include protein structure,
enzyme mechanisms, carbohydrates, metabolism and bioenenergetics, lipids, membranes,
structure of DNA and RNA. BCH310H1 An introductory course in biochemistry intended for students
who are NOT taking BCH321Y as part of their program.
The course is divided into three sections, covering proteins, enzymes, and metabolism.
(Last offered in the 2001-02 academic year) BCH321Y1 An introductory course in biochemistry. Intended for students
specializing in biochemistry and related programs, and requiring a more intensive
background in chemistry than BCH310H.(Last offered in
the 2001-02 academic year) BCH335H1 Structure of DNA and RNA. Catalytic RNAs (ribozymes). Aspects
of DNA topology and chromatin structure. Restriction/modification and fundamentals of
recombinant DNA technology. (First offered in the 2002-03 academic year) BCH340H1 Primary, secondary, tertiary and quaternary structure and
predictions. Protein folding and chaperones. Techniques in protein structure analysis.
Protein-ligand binding and protein-protein interactions. Protein sequence and structure
databases, and introduction to proteomics. (First offered in the 2002-03 academic year) BCH370H1 Techniques in biochemical research and analytical
laboratories. Intended for students who are not proceeding further in biochemistry.
(Enrolment limited) BCH371H1 An introduction to laboratory techniques of modern
biochemistry. Experiments illustrate and develop the concepts described in lecture
courses, and prepare the student for advanced training in biochemical laboratory
techniques. (Enrolment limited) NOTE BCH421H1 Elements of protein structure and conformations are
presented, and their role in protein functions is discussed in detail. Proteins as enzymes
are described, and the structures and functions of membrane proteins are discussed. Recent
advances in protein engineering, and site-directed mutagenesis are presented. (Enrolment
limited). (Last offered in the 2002-03 academic year) BCH422H1 Structure and biogenesis of cell surface membranes;
relationship of structure to functional aspects of the cell surface, cell-cell
interactions, transmembrane signals, hormone receptors, cell surface enzymes and
transport. BCH423H1 Mechanisms of control of mammalian intermediary metabolism.
Kinetics of feedback, allosteric proteins and enzymes; control of carbohydrate, lipid,
amino acid, and nucleotide metabolism; relationship between metabolism and cell growth.
(Offered in alternate years) (Note: This course will be replaced by BCH426H in 2002-03) BCH426H1 A variety of questions are investigated. How is calcium
involved in muscle function and metabolism? What signalling pathways are triggered by
insulin? How do feasting and fasting modulate the use of fuels? How are lipid catabolic
steps involved in platelet activation, stroke and programmed cell death? What roles do
lipoproteins play in cholesterol metabolism? (Note: this course combines BCH423H and BCH429H
into a new course that will be offered every year beginning 2002-03) BCH425H1 Theory and practice of modern biophysical techniques as
applied in the study of structure and function of macromolecules; emphasis on protein
X-ray crystallography, NMR, and other spectroscopic methods; discussion of selected
examples. JBI428H1 Molecular mechanisms involved in the generation and
expression of specific immunity including the structure, function and biosynthesis of
immunoglobulins, the complement systems, transplantation antigens and membrane signalling
events. (Given by the Departments of Biochemistry and Immunology) BCH429H1 Structure, chemistry, and occurrence in biological systems of
glycerides, phospholipids, glycolipids, and sterols, and aspects of their metabolism.
Physical chemistry of complex lipids, principles governing assembly into bilayer
membranes, and methods for studying membrane structure. (Offered in alternate years)
(Note: This course will be replaced by BCH426H in
2002-03) BCH430H1 The objective of the course is to introduce students to the
chemistry of nucleic acids and nucleo proteins and how structure affects their functions
as the reservoir of genetic information and as structural elements in biological systems.
(Last offered in the 2002-03 academic year) BCH440H1 Genetic code and tRNA. Aminoacyl-tRNA synthetases- structure
and function. Structure of ribosomes and their role in translation. Protein synthesis.
Translocation across membranes and the role of chaperones. Post-translational
modifications, sorting, secretion, targeting. (First offered in the 2002-03 academic year) BCH441Y1 This course covers the use of computers in biochemistry and
molecular biology. The main topics include: structure and organization of sequence
databases, genome databases, sequences alignment and search strategies, molecular
evolution and methods for constructing phylogenetic trees. Recent advances in comparative
genomics and proteomics are presented. (First offered in the 2002-03 academic year) BCH471Y1 Experiments demonstrating modern concepts of biochemistry and
molecular biology. (Enrolment limited) BCH473Y1 Research in a particular area of biochemistry, by arrangement
with the Department and the instructor concerned. |
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