A & S Calendar 1998-99: PCL Pharmacology and Toxicology

Arts & Science Calendar 1998-99: Table of Contents: Programs and Courses

PCL Pharmacology and Toxicology

Introduction

Pharmacology is a broadly based and integrative discipline of biology dealing with the properties of chemical compounds and their interactions with living systems. It provides the scientific basis and principles for the study of drug actions in the health sciences, the use of drugs as therapeutic agents or as tools in scientific research, the development and control of pharmaceuticals, the investigation and control of pollutants and poisons in natural and social environments, etc. The Department of Pharmacology, University of Toronto, offers two programs of study:

1. Pharmacology. This program is specifically concerned with the study of chemical (drug) actions on body fluids, cells, tissues and organ systems. Although Pharmacology (and its application in clinical therapeutics) plays a prominent role in Medicine, Dentistry and Pharmacy, there is no equivalence between the professional Pharmacology courses and this Arts and Science program. The objectives of this program are to provide a structured introduction to the scientific aspects of the discipline with exposure to some investigational and research problems and opportunities in preparation for advanced graduate study and research in Pharmacology.

2. Toxicology. This program deals with the study of harmful effects of chemicals and drugs on the health and behaviour of individuals and society. Participating in the program are Pathology, Pharmacology and Pharmacy. This program serves not only as preparation for advanced graduate study and research in Toxicology, but also for toxicological work in forensic science, nutrition and food science, governmental agencies, industry, etc. Students interested in environmental toxicology should consider enroling in Toxicology and Environment, a program offered in conjunction with the Division of the Environment.

Enrolment in both Programs is limited. For further information, consult the Undergraduate Secretary.

Undergraduate Secretary: Dr. D. Kadar, Medical Sciences Building, Room 4209 (978-8920)

Enquiries: Medical Sciences Building, Room 4211 (978-8995)

Faculty Members

Collaborative Programs of the Faculty of Arts and Science & the Faculty of Medicine

Professor Emeriti
L. Endrenyi, Ph D	J.M. Khanna, Ph D
G. Feuer, Ph D	W.H.E. Roschlau, MD
H. Kalant, MD, Ph D	A.K. Sen, MD, Ph D
W. Kalow, MD
Professor and Acting Chair of the Department
A.B. Okey, Ph D
Professors
W.M. Burnham, Ph D	C. Naranjo, MD
H. Cappell, Ph D	R.I. Ogilvie, MD
R.C. Frecker, MD, Ph D	C. Pace-Asciak, Ph D
S. George, MD	K.S. Pang, Ph D
G.J. Goldenberg, MD, Ph D	B.P. Schimmer, Ph D
T. Inaba, Ph D	P. Seeman, MD, Ph D
D. Kadar, Ph D	E.M. Sellers, MD, Ph D
J. Keystone, MD	L. Spero, Ph D
G. Koren, MD	J.P. Uetrecht, MD, Ph D
J.F. MacDonald, Ph D	J.J. Warsh, MD, Ph D
Associate Professors
F.J. Carmichael, MD, Ph D	H.P. Niznik, Ph D
P. Dorian, MD	J.N. Nobrega, Ph D
C. Forster, Ph D	B.F. O'Dowd, Ph D
D. Grant, Ph D	E. Roberts, MD
L. Grupp, D Sc	J. Semple, Ph D
D. Haas, Ph D, DDS	N.H. Shear, MD
D.R. Hampson, Ph D	W.C. Sturtridge, MD, DDS, Ph D
S. Kish, Ph D	B.K. Tang, Ph D
A.E. LeBlanc, Ph D	H. Van Tol, Ph D
P. Li, Ph D	J.W. Wells, Ph D
M. McGuigan, MD	P.G. Wells, Pharm D
M. Moore, MD
Assistant Professors
S. Belo, MD, Ph D	A.J. Lança, MD, Ph D
J. DaSilva, Ph D	J. Mitchell, Ph D
P. Harper, Ph D	P. Pennefather, Ph D
S. Ito, MD	R.D. Prokipcak, Ph D
O. Jones, Ph D	D. Riddick, Ph D
N. Kartner, Ph D	R. Rozmahel, Ph D
I.G. Kerr, MD	R. Tyndale, Ph D

PHARMACOLOGY, TOXICOLOGY PROGRAMS

PHARMACOLOGY (Hon.B.Sc.)M

Enrolment in these Programs is limited. Selection is based on GPA in first and second year required courses. A double specialist degree in Pharmacology and Toxicology (S23401) is offered, but may require an extra year for completion. Consult the Department for details prior to applying.

Specialist program: S20821 (14 full courses or their equivalent, including at least one 400-series course)
First Year: BIO 150Y; CHM 137Y/151Y; MAT 135Y/137Y; PHY 110Y/138Y/140Y (PHY 138Y recommended)
Second Year: BIO 250Y; CHM 240Y
Third Year: BCH 310H, JLM 349H, BCH 370H; PCL 360Y; PSL 302Y*, 372H
Fourth Year: PCL 470Y, 471Y, 472Y; ANA 300Y/302Y/ZOO 263Y/(ANA 301H, ZOO 325H/328H) *NOTE: PSL 201Y is not acceptable

TOXICOLOGY (Hon.B.Sc.) Administered by the Department of Pharmacology.

Specialist program: S25731 (14 full courses or their equivalent, including at least one 400-series course)
First Year: BIO 150Y; CHM 137Y/151Y; MAT 135Y/137Y; PHY 110Y/138Y/140Y (PHY 138Y recommended)
Second Year: BIO 250Y; CHM 240Y
Third Year: BCH 310H, JLM 349H, BCH 370H; PCL 360Y, 362H, 363H; PSL 302Y*
Fourth Year: PCL 364H, 473Y, 474Y, 481H; ANA 301H/CHM 310H/GGR 409H/LMP 301H/NFS 488H (PCL 470Y, although not required, is strongly recommended in 4th year for students planning to apply to the Pharmacology graduate program)

*NOTE: PSL 201Y is not acceptable

PHARMACOLOGY, TOXICOLOGY COURSES

(see Section 4 for Key to Course Descriptions)

For Distribution Requirement purposes, all PCL courses are classified as SCIENCE courses.

PCL299Y
Research Opportunity Program

Credit course for supervised participation in faculty research project. See Research Opportunity Program for details.

PCL360Y
Biological Principles of Pharmacology 78L, 26T

Biological principles of the action of drugs (membranes, enzymes, receptors, neural and hormonal systems, transmission and modulation); absorption, distribution, metabolism, elimination; structure-activity and dose-response relationships; interactions.
Prerequisite: BIO150Y, CHM240Y, and permission of Department

PCL362H
Introductory Toxicology 26L

Toxicological problems encountered in animals and humans; biochemical mechanisms and clinical factors of toxicological significance; models of drug-related diseases.
Prerequisite: BIO150Y, CHM240Y, and permission of the Department

Recommended Co-requisite: BCH310H, JLM349H, PCL360Y

PCL363H
Principles of Pathobiology I 26L

Pathological changes brought about by foreign compounds; application of pathology to the detection of toxic and carcinogenic actions.
Prerequisite: BIO150Y, CHM240Y, and permission of the Department

PCL364H
Principles of Pathobiology II 26L

Principles of pathobiology with emphasis on inflammatory and cardiovascular responses to tissue injury and foreign compounds.
Prerequisite: BIO150Y, CHM240Y, and permission of the Department

PCL470Y
Systems Pharmacology 78L

Concepts of the properties of drugs and chemicals and the mechanisms of their interaction with living systems and their constituent parts. Pharmacology of nervous, cardiovascular, renal, respiratory, gastrointestinal and endocrine systems; endogenous compounds; chemotherapy.
Prerequisite: BCH310H, JLM349H, PCL360Y, PSL302Y, and permission of Department
Co-requisite: ANA300Y/302Y

PCL471Y
Pharmacology Laboratory 104P

Demonstrations, seminars, and laboratory exercises in selected areas of Pharmacology.
Prerequisite: BCH370H, PSL372H, PCL360Y and permission of Department (see NOTE below)

Recommended Co-requisite: PCL470Y

PCL472Y
Project in Pharmacology

Research project with reading assignments and a final written report by special arrangement with professors in the Department of Pharmacology, and other associated Departments.
Prerequisite: Permission of Department (See NOTE below)

PCL473Y
Interdisciplinary Toxicology 52L

Traditional and contemporary problems in toxicology: general aspects, methodology, nature of toxic damage, general biological problems, poisons, applications and social policies.
Prerequisite: BCH310H, JLM349H, PCL360Y, 362H, and permission of Department

PCL474Y
Project in Toxicology

Research project with reading assignments and a final written report by special arrangement with professors in the Departments of Pathology, Pharmacology, Pharmacy and other associated Departments.
Prerequisite: Permission of Department (See NOTE below)

PCL475Y
Neuropsychopharmacology 78L, 26T

Major neuro-psychiatric disease syndromes: clinical pathology and neuronal abnormalities; CNS drugs: theories and mechanisms of action.
Prerequisite: Permission of Department

PCL481H
The Molecular and Biochemical Basis of Toxicology 26L, 26T

The biochemical principles and molecular mechanisms underlying the toxicity of drugs and foreign agents. The sequence of events at the molecular level leading to impairment of cell function and the factors which determine and affect toxicity.
Prerequisite: BCH310H, JLM349H, PCL362H, 363H, and permission of Department

NOTE Enrolment in the Pharmacology Laboratory course, PCL 471Y, is limited. The research Project courses, PCL 472Y and PCL 474Y, require the prior consent of an approved supervisor to supervise the project, and departmental approval before enrolment. Student and supervisor must follow the departmental guidelines for evaluation. It is the student's responsibility to initiate all necessary preparations before the session starts.

We welcome your comments and enquiries.
Revised: April 6, 1998