Biochemistry


On this page: Introduction | Programs |
See also: Faculty Members | Course Descriptions | Course Winter Timetable |

Introduction

Biochemistry is the study of the chemistry of living organisms. Biochemists seek a molecular explanation of life by attempting to understand its underlying principles. Biochemistry is concerned with the relevance of a molecule to an organism and the correlations between its structure and its function. Modern biochemistry grew out of the application of chemical techniques to biological problems and is the foundation of biological science and medicine. In many ways it combines biology and chemistry but the subject now covers such a broad range of activity that it is difficult to draw a neat border around biochemistry. Some of the most exciting areas of current biochemistry research include:

* structural biology
* enzyme mechanisms
* signal transduction and regulation
* biotechnology
* molecular cell biology
* gene expression and development
* metabolic diseases
* proteomics and bioinformatics
* molecular evolution
* protein folding
* membranes and transport

The Biochemistry Specialist Program is academically oriented and designed to provide students with a fundamental understanding of the theoretical and practical aspects of the discipline. The program offers training in problem solving specifically using a molecular approach. Biochemistry specialists will gain experience in critical thinking and the skills required to evaluate scientific rationale. The Biochemistry Major Program offers students fundamental training in the science and gives each student in the program the chance to combine Biochemistry with another relevant Major Program. This may be within the Life Sciences or Basic Sciences, or may be within the arts. For example, the combination of Biochemistry with Economics or with English could provide students with training relevant to the fields of investment within biotechnology or scientific journalism. Students who excel within the Biochemistry Major Program may be offered the chance to enter the Specialist Program at the third year. Frequently students who have completed a B.Sc. in the Specialist Program continue their studies in graduate programs in Biochemistry and other Life Sciences. Graduates from either the Specialist or Major Programs may find employment in research and teaching. Employers include universities and colleges, government laboratories, clinical biochemistry laboratories, forensic laboratories, pharmaceutical companies, biotechnology companies, and many other industries. Skills learned in the Biochemistry Specialist and Major Programs are also helpful in other areas such as marketing, finance, and law. Some biochemistry graduates continue their studies in medicine, dentistry or other health related programs.

Students considering choosing either the BCH Specialist or BCH Major program are encouraged to attend program information sessions to be held by the department in February and March. Please note that the Specialist program is the accepted route to graduate studies in Biochemistry and to careers in research.

Undergraduate Coordinator
Dr. R. R. Baker, roy.baker@utoronto.ca

Undergraduate Administrator:
Brenda Bradshaw, brenda.bradshaw@utoronto.ca

Enquiries:
Medical Sciences Building, ROOM 5207 (416-978-2700)

Web site: www.biochemistry.utoronto.ca

Biochemistry Programs

Biochemistry (Science Program)

The Biochemistry Specialist Program is a Type 3 program. Enrolment is limited and selection is based on performance in First Year courses. Typically, students considered for entrance into the Specialist Program have a GPA greater than 3.0. Students apply via the Faculty’s Subject POSt web site. See the departmental web site at www.biochemistry.utoronto.ca for more information.

Specialist Program

(14 full courses or their equivalent, including at least thREE 400 series courses)

First Year: BIO150Y1; CHM151Y1/ (CHM138H1, CHM139H1); MAT135Y1/MAT136Y1/MAT137Y1; (PHY131H1, PHY132H1)/(PHY151H1,PHY152H1)/110Y1/138Y1/140Y1 [PHY131H1, PHY132H1 recommended]
Second Year:
1. BCH242Y1; (BIO240H1, BIO241H1)/ BIO250Y1; CHM220H1*, CHM247H1/CHM249H1
2. One of: BIO260H1/HMB265H1/CHM221H1*
Third Year: BCH335H1, BCH340H1, BCH371H1; MGY311Y1
Fourth Year:
1. BCH471Y1
2. Four half courses from the following list, including at least two BCH courses:
BCH422H1/BCH425H1/BCH426H1/BCH440H1/BCH441H1/BCH444H1/BCH445H1/BCH446H1/BCH479H1/BCB420H1/CHM447H1/MGY420H1/MGY425H1/MGY428H1/MGY451H1/MGY452H1/MGY470H1/JBI428H1
BCH372Y1/BCH373H1/BCH375H1/BCH472Y1/BCH473Y1: One full credit from these optional research project courses may be taken for the Specialist program**.

Note: Some of the MGY courses noted above have BIO260H1 as prerequisite.

Over the course of the Specialist program, additional credits (to bring the program total to 14 full courses or their equivalent) from the following list: BIO260H1/CHM217H1 (Analytical Chemistry)/CHM221H1* (Physical Chemistry II)/CHM225Y1 (Physical Chemistry)/CHM326H1 (Quantum Mechanics, Spectroscopy)/CHM328H1 (Physical Chemistry) /CHM342H1 (Organic Synthesis)/CHM347H1 (Organic Chemistry of Biological Compounds)/CSC108H1/CSC148H1/CSC150H1 (Introductory Computer Science, only one CSC course can be chosen)/HMB265H1/MAT235Y1/MAT237Y1 (Calculus II)/STA220H1/STA221H1/ any suitaBLE 300-level course from CHM/CSB/EEB/HMB/IMM/LMP/MGY/PCL/PSL (departmental approval required)

*In lieu of CHM220H1 + CHM221H1, CHM225Y1 is an acceptable alternate credit for the Specialist program. CHM225Y1 and CHM221H1 have MAT235Y1/MAT237Y1 (Calculus II) as corequisite.
** Additional BCH research project courses can be taken as part of the 20 full credits needed for your degree, but if you take more than one full credit project course each must be taken with a different research supervisor.

Major Program

(8 full courses or their equivalent, including TWO 400-series half-year courses as noted below)

The Biochemistry Major program is a Type 3 program. Only students with a GPA of 2.5 or higher will be considered for entrance into the Major program. Enrollment is limited and selection is based upon performance in First Year courses. Students may combine this Biochemistry Major with another suitable Major within Science, Humanities, or Social Sciences. In order to be admitted into the program you must have taken at least 4.0 full course equivalents; enrollment is limited. For more information, refer to the Biochemistry web site at www.biochemistry.utoronto.ca

First Year: BIO150Y1; CHM151Y1 (CHM138H1, CHM139H1); MAT135Y1/MAT136Y1/MAT137Y1
Second Year: BCH210H1;(BIO240H1, BIO241H1)/BIO250Y1; CHM247H1/CHM249H1
Third Year:
1. BCH370H1
2. BCH311H1
3. One full-course equivalent from the following list: ANY 300-level course(s) in CHM/CSB/EEB/HMB/IMM/LMP/MGY/PCL/PSL/BIO260H1/CHM217H1/CHM220H1/HMB265H1 (departmental approval required) Students who have completed BCH304H1 may use the credit to partially fulfill this requirement.
Fourth Year: Two of: BCH422H1/BCH425H1/BCH426H1/BCH440H1/BCH441H1/BCH444H1/BCH445H1/BCH446H1/CHM447H1/JBI428H1* (*NOTE JBI428H1 has IMM334Y1/IMM335Y1 as prerequisite)

Bioinformatics and Computational Biology

If we were to choose the single most important scientific advance of the last century, it would be iconified in the image of the double helix of DNA and its implied duality: life propagates as pure information, which is encoded in physical molecules. Molecular biology is an information science as much as it is a physical science. Bioinformatics devises methods to make biological information computable - to abstract properties of molecules, cellular systems and biological organisms, to efficiently store and retrieve the very large volumes of data that are being accumulated, to support sensitive comparisons and to mine the data with sophisticated statistical tools. Computational biology is bioinformatics’ goal: to advance our understanding of life through computational analysis, modeling, and prediction. However, integrating the two cultures of computer science and life science has been a challenge, and a bottleneck for progress has emerged from a lack of dually qualified researchers. The Bioinformatics and Computational Biology specialist program is designed to provide a balance between its foundational subjects and to cover advanced topics in both the theoretical and the life-sciences. It aims to train the generalist, who will become creative at the intersection of two fields, rather than pursue their subspecialization. The program draws on the University’s state-of-the-art facilities across several departments, as well as being firmly embedded in a comprehensive landscape of graduate and postgraduate research in one of the University’s priority areas. Graduates of the program would typically pursue graduate studies in any of the participating departments: Computer Science (from the biocomputing stream, see below), Biochemistry, Botany or Zoology (from the bioanalyst stream). Important advances in the computer sciences have been motivated by these needs and there is virtually no field in the life-sciences and in molecular medicine that does not critically depend on insightful data analysis.

Bioinformatics and Computational Biology (Science Program)

The Bioinformatics and Computational Biology Program is jointly sponsored by the Departments of Biochemistry, Botany, Computer Science and Zoology. Enrollment is limited and selection is based on performance in the required first year courses.

Specialist program:

(16.5 full courses or their equivalent)

First Year: MAT135Y1/MAT137Y1/MAT157Y1; (CSC107H1/CSC108H1, CSC148H1)/CSC150H1; CSC165H1; CHM151Y1/(CHM138H1, CHM139H1); BIO150Y1; writing requirement (0.5 credit, see Note 2 to Comprehensive Program in Computer Science)
Second Year: MAT223H1/MAT240H1; STA247H1; STA248H1; CSC207H1; CSC236H1/CSC240H1; BCH242Y1; BIO250Y1

Third Year: CSC263H1/CSC265H1; CSC321H1/CSC343H1; CSC373H1/CSC375H1; BCH441H1/BIO472H1; MGY311Y1/(BIO260H1, BIO349H1)
Fourth Year:

Bio Analyst Stream (preparation for life-science graduate programs) BCB410H1; BCB420H1; CSC411H1; five half credits from (BCB430Y1, BCH335H1, BCH340H1, MGY420H1, MGY425H1, MBY428H1, BCH422H1, BCH426H1, BCH440H1, MGY460H1, BIO460H1, BIO473H1, BOT421H1, BOT450H1, BOT458H1)
Bio Computing Stream (preparation for computer-science graduate programs) BCB410H1; BCB420H1; CSC411H1; CSC336H1/CSC350H1; one half credit from (MGY420H1, MGY425H1, MBY428H1, BCH422H1, BCH426H1, BCH440H1, MGY460H1, BIO460H1, BIO473H1, BOT421H1, BOT450H1, BOT458H1); three half credits from (BCB430Y1, CSC324H1, CSC363H1, MAT244H1, CSC310H1 CSC321H1,CSC343H1, CSC412H1 CSC456H1)

Bioinformatics & Computational Biology Courses

See page 33 for Key to Course Descriptions. For Distribution Requirement purposes, all BCB courses are classified as SCIENCE courses (see page 26). For details on BCB courses, see www.biochemistry.utoronto.ca/bcb

BCB410H1 Applied Bioinformatics [24L, 13P]
Practical introduction to concepts, standards and tools for the implementation of strategies in bioinformatics and computational biology.
Prerequisite
: CSC263H1, CSC373H1, MGY311Y1/ (BIO260H1, BIO349H1) or special permission

BCB420H1 Computational Systems Biology [24L]
Current approaches to using the computer for analyzing and modeling biology as integrated molecular systems. The course complements an introductory Bioinformatics course such as BCH441H1. (Enrolment limited).
Prerequisite: MGY311Y1/(BIO260H1, BIO349H1), BCB441H1/CSB472H1 or special permission,

BCB430Y1 Special Project in Bioinformatics and Computational Biology [TBA]
An opportunity for specialized individual research in bioinformatics and computational biology by arrangement with the course coordinator and a supervisor.
Prerequisite: GPA 3.0 and written acceptance by coordinator and supervisor.
Co-requisite: BCB410H1, BCB420H1
Exclusion
: Any other 4th year special project course taken at the same time.

Molecular Biophysics (Science Program): See Physics