Pharmacology and Toxicology Courses

Key to Course Descriptions.

For Distribution Requirement purposes, all PCL courses are classified as SCIENCE courses (see page 26).

| Course Winter Timetable |


PCL102H1
The Art of Drug Discovery [24L]

This course introduces students to the processes and strategies for discovering new drugs with a special focus on current and emerging approaches for the rational design of drugs that are both effective and safe.


PCL299Y1
Research Opportunity Program

Credit course for supervised participation in faculty research project. Details here.


PCL201H1
Introduction to Pharmacology and Pharmacokinetic Principles [36L, 6T]

A general introduction to pharmacology and pharmacokinetics (PK). Topics include: absorption, distribution, biotransformation, elimination, calculation of dosages and PK parameters, variability in drug response, adverse drug reactions and special interest topics.
Recommended Co-requisites: BIO240H1, BIO241H1, CHM247H1/CHM249H1


PCL302H1
Pharmacodynamic Principles [36L]

Topics include biological action of drugs on membranes, enzymes, receptors, neural and hormonal systems, transmission and modulation.
Prerequisites: BIO240H1, BIO241H1, CHM247H1/CHM249H1, PCL201H1


PCL362H1
Introductory Toxicology [26L]

Toxicological problems encountered in animals and humans; biochemical mechanisms and clinical factors of toxicological significance; models of drug-related diseases.
Prerequisites: BCH210H1, BIO240H1, BIO241H1, CHM247H1/CHM249H1, PCL201H1
Recommended Co-requisite: BCH311H1/CSB349H1, PCL302H1


PCL365Y1
Toxicology Laboratory [48P, 48T]

A hands-on laboratory course exploring a wide variety of modern experimental techniques currently utilized in toxicology. This course will provide the experimental theory of how the techniques work and their advantages and disadvantages, while additionally allowing students to perform these techniques in the process of addressing toxicological problems. Enrollment in this course is restricted to students enrolled in the Biomedical Toxicology Specialist and Double Specialist programs.
Prerequisites: PCL201H1
Co-requisites: PCL302H1, PSL302Y1


PCL376H1
Experimental Design and Data Analysis for Pharmacology and Toxicology [36L]

A practically oriented course, focused on experimental design and the analysis of pharmacological and toxicological data. Topics include: principles of experimental design, data analysis and statistical tests appropriate for each type, use of computing statistical packages, analysis of dose-response and time-response curves and analysis of receptor binding assays.
Prerequisite: PCL201H1
Co-requisite: PCL302H1
Exclusion: PCL476H1


PCL389H1
Understanding the Role of Pharmacology and Toxicology in Society [24L]

This service learning course explores issues surrounding the effects that pharmaceuticals and chemicals have in society. It includes: scientific background and theory on selected pharmaceuticals and chemicals; complex topics associated with social, legal and governmental policy found in the Pharmacology and Toxicology field with an integration of community-based activities.
Prerequisite: PCL201H1
Co-requisite: PCL302H1; PSL302Y1


PCL470Y1
Systems Pharmacology [61L, 9S]

Concepts of drug properties and their interaction with living systems and their constituent parts will be discussed. Mechanism of action and pharmacological properties of drugs acting on the autonomic and central nervous systems, cardiovascular, renal, respiratory, gastrointestinal, immunological and endocrine systems; endogenous compounds; antimicrobial and anti-inflammatory drugs, chemotherapy, pharmacogenomics and special topics in pharmacology.
Prerequisites: BCH210H1, PCL201H1, PCL302H1, PSL302Y1


PCL471Y1
Pharmacology Laboratory [56P, 40T]

Demonstrations, seminars, and laboratory exercises in selected areas of pharmacology. Enrollment in this course is restricted to students enrolled in the Pharmacology Specialist and Double Specialist programs.
Prerequisites: PSL372H1, PCL201H1, PCL302H1
Co-requisite: PCL470Y1


PCL472Y1
Project in Pharmacology

This course affords students an opportunity for hands-on research experience in a laboratory or applied pharmacology setting. Students will work under the supervision of a faculty member and will submit a final written report. Enrollment is limited and requires permission from the Department of Pharmacology and Toxicology. It is the student’s responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors can be obtained from the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department of Pharmacology and Toxicology) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology.
Prerequisites: PCL201H1, PCL302H1, PCL376H1 and permission of Department
Exclusion: PCL474Y1


PCL473Y1
Interdisciplinary Toxicology [48L]

A survey course examining traditional and contemporary problems in toxicology. The toxicities associated with a variety of toxins and toxicants are examined. General principles and the application of toxicological knowledge are discussed including clinical toxicology, forensic toxicology, and risk assessment.
Prerequisites: BCH210H1, PCL201H1, PCL302H1, PCL362H1
Recommended preparation: BCH311H1/CSB349H1


PCL474Y1
Project in Toxicology

This course affords students an opportunity for hands-on research experience in a laboratory or applied toxicology setting. Students will work under the supervision of a staff member and will submit a final written report. Enrollment is limited and requires permission from the Department of Pharmacology and Toxicology. It is the student’s responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors can be obtained from the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department of Pharmacology) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology.
Prerequisites: PCL201H1, PCL302H1, PCL376H1 and permission of Department
Exclusion: PCL472Y1


PCL475Y1
Neuropsychopharmacology [72L, 24T]

Major neuro-psychiatric disease syndromes: clinical pathology and neuronal abnormalities; CNS drugs: theories and mechanisms of action.
Prerequisite: Enrollment is limited to students with a minimum CGPA of 3.0.


PCL477H1
The DNA Damage Response in Pharmacology and Toxicology [24L]

Many anticancer drugs and environmental agents exert their cytotoxic effects through DNA damage. This course explores specific pharmacological and toxicological agents that damage DNA and discusses how mammalian cells respond to this DNA damage.
Prerequisite: BCH210H1/BCH242Y1
Recommended Preparation: PCL201H1, PCL302H1, BCH311H1/CSB349H1/JLM349H1/MGY311Y1/PSL350H1


PCL481H1
The Molecular and Biochemical Basis of Toxicology [24L]

The biochemical principles and molecular mechanisms underlying the toxicity of drugs and foreign agents. The sequence of events at the molecular level leading to impairment of cell function and the factors which determine and affect toxicity.
Prerequisites: PCL201H1, PCL302H1, PCL362H1, BCH210H1, LMP363H1