| Course Winter Timetable |

PSL201Y1

Basic Human Physiology 52L
A survey course intended for students who are not proceeding further in Physiology.
Exclusion: Any PSL course taken previously or concurrently; ZOO252Y1
Prerequisite: BIO150Y1

PSL299Y1

Research Opportunity Program

Credit course for supervised participation in faculty research project. See page 44 for details.

PSL300H1

Human Physiology I 39L
Principles of neurophysiology and endocrinology for students enroled in the Neuroscience program.
Exclusion: PSL201Y1, PSY391H1
Prerequisite
: BIO150Y1; CHM138H1; PHY100-series

PSL301H1

Human Physiology II 39L
Principles of respiratory, cardiovascular, gastrointestinal, renal and reproductive physiology for students enroled in the Neuroscience
program.
Exclusion: PSL201Y1
Prerequisite
: BIO150Y1; CHM138H1; PSL 300H1

JBO302Y1

Human Physiology and Biophysics 78L, 12T
Principles of Human Physiology with tutorials on the biophysical concepts applied to physiological processes. Restricted to students
enroled in the Biophysics and Physiology (Theoretical) programs
Exclusion: PSL201Y1, 302Y1
Prerequisite
: BIO150Y1; CHM138H1; MAT135Y1/137Y1; PHY138Y1/140Y1

PSL302Y1

Human Physiology 78L
Principles of Human Physiology for students enroled in Basic Medical Science programs.
Exclusion: PSL201Y1
Prerequisite: BIO150Y1, CHM138H1; MAT100-series/PHY100-series

PSL303Y1

Topics in Cellular, Molecular and Organismic Physiology 78L, 26T
Using homeostasis and feedback as a unifying theme, topics in control systems, cell signalling, rhythms, environmental adaptations
and body weight regulations are examined. Tutorials use computer simulations and problem sets.
Prerequisite: JBO302Y1/PSL302Y1/ZOO252Y1, MAT 100-series, PHY 100-series
Co-requisite: PSL372H1, 374H1 or permission of Department

PSL372H1

Mammalian Physiology Laboratory 13L, 39P
A laboratory course covering selected topics in physiology.
Prerequisite: BIO250Y1, BCH210H1/CHM240Y1, MAT 100-series, PHY 100-series
Pre- or Co-requisite: PSL302Y1, BCH370H1 (recommended)

PSL374H1

Advanced Physiology Laboratory 13L, 13S, 39P
A problem-based laboratory course focussed on the integration of organ systems to understand the control mechanisms of body
function.
Prerequisite: BIO250Y1, MAT235Y1/PHY238Y1, PSL302Y1/ZOO252Y1, PSL372H1
Co-requisite: BCH370H1, PSL303Y1

PSL420H1

Reproduction I: Development and Function 26L
This course provides an in-depth review of the development and function of the male and female reproductive systems. Topics
include sex determination and differentiation, gametogenesis, hormonal control of the reproductive systems, the female ovulatory
cycle, seasonal breeding, sexual behaviour, fertilization and implantation.
Prerequisite: PSL302Y1

PSL421H1

Reproduction II: Pregnancy and Birth 26L
General overview of the integrated physiologic events associated with pregnancy and birth. The approach emphasizes physiologic
processes using insights gained from studies of humans, animals, cells and genes. Where appropriate the clinical consequences of
aberrant development are reviewed.
Prerequisite: PSL302Y1
Recommended preparation: PSL420H1

PSL424H1

Endocrinology and Neuroendocrinology 26L
Selected topics in the fields of neuroendocrinology, steroid endocrinology and the regulation of energy metabolism illustrate the
general principles underlying the control of complex endocrine systems. Particular emphasis is placed on the evolutionary
development of hormone systems through gene duplication and differentiation.
Prerequisite: PSL302Y1

PSL425H1

Integrative Metabolism and its Endocrine Regulation 26L
This course integrates the newest findings and experimental approaches from cellular and molecular biology into metabolic function
at the tissue, organ and whole body level.
Prerequisite: BCH210H1/310H1, PSL302Y1
Recommended preparation: PSL303Y1

PSL431H1

Mathematics For Physiology 26L, 24P
General computer and mathematical techniques applied to physiology. FORTRAN/BASIC programming, solution of ordinary
differential equations, curve fitting, linear systems analysis.
Prerequisite: MAT235Y1/237Y1
Recommended preparation: A 200-series PHY course

PSL432H1

Theoretical Physiology 26L
Theoretical treatment of physiology. Mathematical modelling and advanced analysis of physiological systems.
Prerequisite: MAT235Y1/237Y1; APM346H1/MAT244H1/PSL431H1
Recommended preparation: PHY200-series; PSL201Y1/302Y1/ZOO252Y1

PSL433H1

Analytical Neuroscience 26L, 10P, 5T
Math of neurons, synapses, neural networks in brain. Comparison with experimental results. Labs for simulations. Two streams,
marked appropriately: Biol-advantaged, Math-acquired (paper presentations) and Math-advantaged, Biol-acquainted (probsets)
Prerequisite: MAT235Y1/237Y1, PSL300H1/302Y1/ZOO332H1
Recommended preparation: MAT244H1, PSL303Y1

PSL440Y1

Neuroscience I: Systems and Behaviour 78L
Introduction to systems neuroscience. A review of basic neuroanatomy and physiology followed by in-depth study of selected sensory
and motor systems. Students with an elementary neuroscience background progress to reading neuroscience literature on their own.
Prerequisite: PSL300H1/302Y1/PSY290H1/ZOO332H1 or equivalent

PSL443H1

Motor Control Systems 26L, 10P
Control of body movement and posture by the nervous system in normal and pathological conditions. Topics include nonlinear
dynamical systems, central pattern generators in the cerebral cortex, brainstem and spinal cord, reflexes, and basal ganglia-cerebellar
function.
Prerequisite: PSL300H1/302Y1

PSL444Y1

Neuroscience II: Cellular and Molecular 78L
Overview of the fundamentals of cellular and molecular aspects of brain function. Course material is updated yearly to reflect the
rapid evolution of ideas in Neuroscience.
Prerequisite: PSL300H1/302Y1/ZOO332H1

PSL452H1

Membrane Physiology 26L
Biophysics and molecular biology of ion channels. Topics include equivalent circuits for cells, molecular structure of voltage-gated
channels, distribution of channels, relationship between single-channel and whole-cell recording and regulation of channel function
by voltage, phosphorylation, G-proteins and metabolites.
Prerequisite: PSL303Y1
Recommended preparation: PSL431H1, 432H1

PSL454H1

Physiological Instrumentation and Electronics 13L, 39P
A practical approach to instrumentation as a preparation for using sophisticated measurement systems.
Prerequisite: PHY138Y1 or equivalent

PSL460H1

Molecular Physiology 26L, 4S
An overview of the ways in which techniques in molecular biology are being used to resolve current issues in physiology. The
systems to be studied include individual cells, organ systems, integrated systems, and whole animal physiology and pathophysiology.
Prerequisite: BCH210H1/310H1, BIO250Y1, JLM349H1, PSL302Y1

PSL462H1

Molecular Aspects of Cardiovascular Function 26L
Heart anatomy and development, ion channels and contractile proteins involved in cardiac and smooth muscle contraction are studied.
Emphasis is on regulation of electrical and contractile function of kinases, metabolism, volume and ions.
Prerequisite: PSL303Y1

PSL470H1

Cardiovascular Physiology 26L, 13T
Development of the cardiovascular system from conception to adulthood with particular emphasis on maturational changes, age-
related differences and developmental problems from cellular/molecular to whole organ/system.
Prerequisite: PSL302Y1

PSL471H1

Adaptation to Environment 26L, 3P
In-depth study of specific topics in human physiological response to conditions such as altitude, cold, exercise and birth. Students are
required to make field trips to physiological laboratories on campus and at the Defence and Civil Institute of Environmental
Medicine.
Prerequisite: PSL302Y1

PSL472H1

Sleep Physiology and Chronobiology 26L
An in-depth analysis of the basic physiology underlying sleep and circadian rhythms, and of their impact on important physiological
processes, of which effects on cardio-respiratory systems are emphasized.
Prerequisite: PSL302Y1

PSL497H1

Scientific Communication 26L/ST
Students learn to read, write and speak about current research in Physiology.
Prerequisite: PSL302Y1

PSL498Y1/499H1

Project in Physiology 156P/78P
Laboratory research project with reading assignments leading to a final report. By special arrangement with a Physiology staff
member after admission to course. PSL498Y1 is recommended for students applying to the Physiology graduate program.
Prerequisite: PSL303Y1, 372H1, 374H1, permission of Department