| Course Winter Timetable |

BCH299Y1
Research Opportunity Program

Credit course for supervised participation in faculty research project. See page 44 for details.

BCH210H1
Introductory Biochemistry 39L

An introductory course in biochemistry covering proteins, enzymes, and metabolism. This course is intended for students who are
NOT taking BCH242Y1 as part of their program.
Exclusion: BCH242Y1/310H1/320Y1/321Y1/CHM379H1/361H1(E)/362H(E)
Prerequisite: CHM138H1, 139H1

BCH242Y1
Biochemistry 78L

An introduction to biochemistry for students specializing in biochemistry and related specialist programs. The major topics include
protein structure, enzyme mechanisms, carbohydrates, metabolism and bioenenergetics, lipids, membranes, structure of DNA and
RNA.
Exclusion: BCH210H1/310H1/320Y1/321Y1/CHM379H1/361H1(E)/362H(E)
Prerequisite: CHM138H1, 139H1

BCH335H1
Nucleic Acids and Recombinant DNA Technology 26L

Structure of DNA and RNA. Catalytic RNAs (ribozymes). Aspects of DNA topology and chromatin structure. Restriction/
modification and fundamentals of recombinant DNA technology.
Exclusion: BCH430H1
Prerequisite: BCH242Y1

BCH340H1
Proteins: from Structure to Proteomics 26L

Primary, secondary, tertiary and quaternary structure and predictions. Protein folding and chaperones. Techniques in protein structure
analysis. Protein-ligand binding and protein-protein interactions. Protein sequence and structure databases, and introduction to
proteomics.
Exclusion: BCH421H1
Prerequisite: BCH242Y1

BCH370H1
Laboratory Course in Biochemical Techniques 13L, 39P

Techniques in biochemical research and analytical laboratories. Intended for students who are not proceeding further in biochemistry.
(Enrolment limited)
Exclusion: BCH371H1
Prerequisite: BCH210H1/(BIO250Y1, CHM240Y1/248Y1)

BCH371H1
A Laboratory Course in Biochemistry 75P

An introduction to laboratory techniques of modern biochemistry. Experiments illustrate and develop the concepts described in
lecture courses, and prepare the student for advanced training in biochemical laboratory techniques. (Enrolment limited)
Exclusion: BCH370H1
Prerequisite: BCH242Y1/(BIO250Y1, CHM222Y1/225Y1, CHM240Y1/248Y1)
NOTE
Students who have completed Erindale CHM361H1 and 362H may enrol in 400-series lecture courses if they
obtain permission of the Department

BCH421H1
Protein Structure and Function 26L

Elements of protein structure and conformations are presented, and their role in protein functions is discussed in detail. Proteins as
enzymes are described, and the structures and functions of membrane proteins are discussed. Recent advances in protein engineering,
and site-directed mutagenesis are presented. (Enrolment limited). (Last offered in the 2002-03 academic year)
Prerequisite: BCH321Y1/CHM379H1

BCH422H1
Cell Surface Biochemistry 26L

Structure and biogenesis of cell surface membranes; relationship of structure to functional aspects of the cell surface, cell-cell
interactions, transmembrane signals, hormone receptors, cell surface enzymes and transport.
Prerequisite: BCH210H1/242Y1/310H1/321Y1

BCH425H1
Biophysical Methods 26L

Theory and practice of modern biophysical techniques as applied in the study of structure and function of macromolecules; emphasis
on protein X-ray crystallography, NMR, and other spectroscopic methods; discussion of selected examples.
Prerequisite: BCH321Y1/340H1/CHM379H1

BCH426H1
Signals Regulating Metabolic Pathways 26L

A variety of questions are investigated. How is calcium involved in muscle function and metabolism? What signalling pathways are
triggered by insulin? How do feasting and fasting modulate the use of fuels? How are lipid catabolic steps involved in platelet
activation, stroke and programmed cell death? What roles do lipoproteins play in cholesterol metabolism?
Prerequisite: BCH210H1/242Y1/310H1/321Y1, MGB311Y1/JLM349H1

JBI428H1
Molecular Immunology 26L

Molecular mechanisms involved in the generation and expression of specific immunity including the structure, function and
biosynthesis of immunoglobulins, the complement systems, transplantation antigens and membrane signalling events. (Given by the
Departments of Biochemistry and Immunology)
Prerequisite: BCH210H1/242Y1/310H1/321Y1, IMM334Y1/335Y1
Recommended preparation:

JLM349H/MGB311Y
BCH430H1

Nucleic Acid Biochemistry 26L
The objective of the course is to introduce students to the chemistry of nucleic acids and nucleo proteins and how structure affects
their functions as the reservoir of genetic information and as structural elements in biological systems. (Last offered in the 2002-03
academic year)
Prerequisite: BCH310H1/321Y1

BCH440H1
Protein Biosynthesis 26L

Genetic code and tRNA. Aminoacyl-tRNA synthetases- structure and function. Structure of ribosomes and their role in translation.
Protein synthesis. Translocation across membranes and the role of chaperones. Post-translational modifications, sorting, secretion,
targeting.
Prerequisite: BCH210H1/242Y1/310H1/321Y1, MGB 311Y1/JLM 349H1

BCH441H1
Bioinformatics 26L

This course covers the use of computers in biochemistry and molecular biology. The main topics include: structure and organization
of sequence databases, genome databases, sequences alignment and search strategies, molecular evolution and methods for
constructing phylogenetic trees. Recent advances in comparative genomics and proteomics are presented.
Prerequisite: BCH210H1/242Y1/310H1/321Y1, MGB311Y1/JLM349H1

BCH471Y1
Advanced Biochemistry Laboratory 168P

Experiments demonstrating modern concepts of biochemistry and molecular biology. (Enrolment limited)
Prerequisite: BCH371H1, 321Y1/335H1+340H/CHM361(E)+362H(E)+371H(E)

BCH473Y1
Special Work in Biochemistry 154P

Research in a particular area of biochemistry, by arrangement with the Department and the instructor concerned.
Prerequisite: BCH321Y1/335H1 +340H, 371H and permission of Department
Co-requisite: BCH471Y1