| Course Winter Timetable |

LMP299Y1
Research Opportunity Program

Credit course for supervised participation in faculty research project. See page 44 for details.

LMP300Y1
Introduction to Pathobiology 52L, 6P

Concepts in pathogenesis; cell injury and death; tissue structure, wound healing; repair and fibrosis. Molecular basis of major organ
system pathology. The laboratory examines gross anatomical specimens and introduces histopathology. Enrolment is limited to
students specializing in pathobiology who have completed the first and second year requirements of the program.
Exclusion: LMP301H1

LMP301H1
Introduction to the Biochemistry of Human Disease 26L

Introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological
functions. The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained. Not
intended for students in the Pathobiology Specialist program.
Exclusion: LMP300Y1
Prerequisite: BCH210H1
Co-requisite: PSL302Y1/JBO302Y1

LMP363H1
Principles of Pathobiology (formerly PCL363H) 26L

Pathological changes brought on by foreign compounds; applications of pathology to the detection of toxic carcinogenic actions.
Prerequisite: BIO250Y1, CHM247H1

LMP365H1
Neoplasia 20L, 6P

A general introduction to the cellular and molecular aspects of cancer and its etiology. The laboratory component presents the range
of benign and malignant tumor types at the gross and histological levels. Pathophysiology of cancer, invasion and metastases, role of
the immune system.
Co-requisite: LMP300Y1 or permission of department

LMP402H1
Inflammation and Infection 26L

Cellular and molecular components of the inflammatory response. Activation of the inflammatory response by viral and microbial
pathogens. Tissue pathology resulting from the inflammatory response. Evolution of pathogens to avoid and exploit the response.
Prerequisite: IMM334Y1/MBY(377H1, 378H1)

LMP403H1
Immunopathology 26L

The immune system in disease. Responses of the immune system to host invasion, injurious stimuli, and transplantation.
Immunopathology of organ-specific diseases including pancreas, gut, liver, heart, kidney, and blood. Intended for students
specializing in pathobiology or related programs.
Prerequisite: IMM334Y1/LMP300Y1

LMP404H1
Bone and Skeletal Disorders 26L

Focused broadly on the theme of calcium, from its cellular function and the endocrine systems regulating it, to bone structure and
biomechanics. Selected bone diseases, their genetic variability, and treatment strategies are considered in depth. (First offered in Fall
2002)

LMP405Y1
Project in Laboratory Medicine and Pathobiology 156P

A self-contained research project to be completed under the supervision of a faculty member. The main areas of research are as listed
in the description of the Department (above). The student will normally have completed three full years of study, and is expected to
devote at least one full day per week to the project. Admission is by arrangement with the Department and with a particular
supervisor. A list of potential supervisors is available from the Departmental Office and on our web site.
Prerequisite: BCH210H1/310H1, LMP300Y1/363H1/365H1 and permission of department

LMP406H1
Pathobiology of the Cardiovascular System 26L

Pathobiology of the heart, blood vessels, and lymphatic system. Congenital diseases of the heart, ischemic injury, stroke. Treatments
of vascular disease and cardiovascular biomaterials. Major focus on atherosclerosis and hypertension. The emphasis is on the
underlying cell biology of these processes.

LMP436H1
Microbial Pathogenesis (formerly MPL436H) 39L

Molecular mechanism involved in pathogenesis of infectious disease. Topics include recurrent themes in the establishment of
infectious disease, such as adherence and spread of pathogenic bacteria as well as evasion of host defences. Emphasis is placed on
genetic characterization and expression of virulence determinants and on interactions between bacterial pathogens and their hosts.
Prerequisite: MBY(377H1, 378H1)
Recommended preparation: IMM334Y1