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MGB Molecular Genetics and Molecular Biology Courses MGB299Y1 Credit course for supervised participation in faculty research project. See page 44 for details. MGB311Y1 DNA replication, DNA repair and mutation, recombination,
transcription, RNA modification and processing, the genetic code and tRNA, translation,
regulation of gene expression, development and differentiation, molecular evolution. MGB312H1 Laboratory experiments in genetics of selected organisms.
Topics studied include Mendelian genetics, linkage and recombination, complementation,
analysis of chromosome rearrangements, mutant selection and analysis in plants and
bacteria, and genetic crosses with Drosophila, plants, bacteria and bacteriophages. MGB420H1 This course describes regulatory mechanisms controlling gene
expression in prokaryotes and eukaryotes. The lectures are designed to promote discussion
of various experimental approaches. Topics include: assembly of a transcription complex;
initiation of transcription; role of sigma factors and transcription factors; role of
regulators of transcription; regulation of SV40 transcription; lambda antitermination;
antitermination in HIV-1. MGB425H1 This course presents and integrates molecular aspects of
signal transduction and cell cycle regulation in eukaryotic cells from yeast to humans.
Emphasis is on recent advances in growth factor receptor signalling, modular protein
domains, and the recurrent role of protein phosphorylation and protein-protein
interactions in cell regulation. MGB430H1 DNA purification, DNA transfer in microorganisms, restriction
endonucleases, gel electrophoresis, recombinant DNA methods. MGB451H1 Basic and advanced principles of genetics are applied to the
study of eukaryotic model organisms. The differentiation and development of yeast,
nematode worms and fruit flies are covered. Emphasis is placed on genetic approaches and
developmental principles that can be broadly applied to other more complex organisms. MGB452H1 This is a companion course to MGB451H.
Advanced genetic principles and approaches, used in the study of fly and mouse
development, are introduced. Emphasis is placed on developmental processes that are
conserved among these major model organisms. MGB460H1 Structure, organization, expression and regulation of genes
in the nucleus, and chloroplast of photosynthetic organisms; regulation of gene expression
during plant development and in response to the environment. MGB470H1 Mutants of mammalian cells in culture, human cytogenetics and
chromosome structure, human gene mapping, molecular genetic analysis and disease,
oncongenes and cancer. MGB480Y1 TBA |
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