	Faculty of Arts & Science 2011-2012 Calendar

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Pharmacology and Toxicology

Faculty

Professors Emeriti
W.M. Burnham, Ph D
L. Endrenyi, Ph D
J.N. Heersche, Ph D
T. Inaba, Ph D
D. Kadar, Ph D
H. Kalant, MD, Ph D
J.M. Khanna, Ph D
M.W. Milgram, Ph D
P.J. O'Brien, Ph D
R.I. Ogilvie, MD
A. B. Okey, Ph D
C. Pace-Asciak, Ph D
W.H.E. Roschlau, MD
B.P. Schimmer, Ph D
P. Seeman, MD, Ph D
E.M. Sellers, MD, Ph D
F.A. Sunahara, Ph D

Professor and Chair of the Department
D.M. Grant, Ph D

Professors
U.E. Busto, Pharm D
P. Dorian, MD
S. George, MD
D.R. Hampson, Ph D
D. Haas, Ph D, DDS
S. Ito, MD
J. Keystone, MD
S. Kish, Ph D
G. Koren, MD
K. Lanctôt, Ph D
A.D. Lê, Ph D
J.F. MacDonald, Ph D
M. Moore, MD
C. Naranjo, MD
J.N. Nobrega, Ph D
B.F. O'Dowd, Ph D
K.S. Pang, Ph D
J.D. Parker, MD
P. Pennefather, Ph D
E.A. Roberts, MD
J. Semple, Ph D
N.H. Shear, MD
O.C. Snead III, MD
R. Tyndale, Ph D
J.P. Uetrecht, MD, Ph D
J.J. Warsh, MD, Ph D
J.W. Wells, Ph D
P.G. Wells, Pharm D

Associate Professors
F.J. Carmichael, MD, Ph D
N. Chirgadze, Ph D
Y. Finkelstein, MD
L. Grupp, D Sc
P. Harper, Ph D
B. Le Foll, MD, Ph D
P. Li, Ph D
R.S. McIntyre, MD
J.P. McPherson, Ph D
J.H. Meyer, MD, Ph D
J. Mitchell, Ph D
H-W Park, Ph D
A. Petronis, MD, Ph D
M. Piquette-Miller, Ph D
D. Riddick, Ph D
M. Schapira, Ph D
A.H.C. Wong, MD, Ph D

Assistant Professors
S. Belo, MD, Ph D
B. Brands, Ph D
A.J. Lana, MD, Ph D
R.R. Laposa, Ph D
J. Matthews, Ph D
J.M. Mayer, Ph D
N. Mittmann, Ph D
M.G. Neuman, Ph D
G. Rachamin, Ph D
A.J. Ramsey, Ph D
A. Salahpour, Ph D
C. Toal, Ph D
D. Tomkins, Ph D
M. Zack, Ph D
L. Zawertalio, Ph D

Senior Lecturer
C. Woodland, Ph D

Lecturer
M.I. Arnot, Ph D

Introduction

Pharmacology and Toxicology are integrative biological sciences that examine the properties of chemical compounds and their interactions with living systems. They provide the scientific basis for the study of chemical actions in the health sciences, the use of drugs as therapeutic agents or as tools in scientific research, the development and control of pharmaceutical products, and the investigation and control of pollutants and poisons in natural and social environments. The Department of Pharmacology and Toxicology offers four Specialist and two Major undergraduate programs of study that are jointly sponsored by the Faculties of Arts and Science and Medicine. The Specialist programs have the added benefit of providing students with opportunities to learn advanced laboratory techniques and to gain real-world experience through supervised independent research projects and participation in the Professional Experience Year Internship (see below). Students who intend to pursue graduate research and/or careers in pharmacology or toxicology are encouraged to enroll in a Specialist program because of the opportunities for additional experiential learning.

1. Specialist Program in Pharmacology. Pharmacology is the study of the interactions of chemical substances with living systems. This program aims to provide students with an understanding of the properties of drugs and their actions from the molecular level to whole body systems, and to prepare them for research- or non-research -based careers including positions in the pharmaceutical industry, government, research institutes and universities. Students learn about basic and clinical pharmacology and related areas through lectures, tutorials, laboratories, and independent research projects. The senior research project course enables students to gain valuable research experience while working under the supervision of a faculty member in a laboratory or non-laboratory-based setting. Specialist students also have the opportunity to participate in the Professional Experience Year Internship (see below) in which they gain valuable experience in a paid employment placement. Pharmacology (and its application in clinical therapeutics) plays a prominent role in medicine, dentistry and pharmacy. While some students take the Pharmacology Specialist program in preparation for these professional programs, students are advised to contact the respective faculties directly for questions related to transfer credits.

2. Specialist Program in Biomedical Toxicology. This program deals with the study of the harmful effects of chemicals on the health and behaviour of individuals and society. The safety/toxicity of a wide array of chemicals is examined including pharmaceutical preparations, herbal products, natural toxins, and environmental contaminants with a focus on their effects on human health. This program emphasizes the application of toxicological knowledge and risk assessment and can serve not only as preparation for graduate study and research in toxicology, but also for professional programs and careers in forensic science, nutrition and food science, governmental agencies, consulting agencies, and industrial settings including the pharmaceutical industry. Students learn about basic and clinical toxicology and related areas through lectures, tutorials, laboratories, and independent research projects. The senior research project course enables students to gain valuable toxicology research experience while working under the supervision of a faculty member in a laboratory or non-laboratory-based setting. Specialist students also have the opportunity to participate in the Professional Experience Year Internship (see below) in which they gain valuable experience in a paid employment placement.

3. Double Specialist Program in Pharmacology and Biomedical Toxicology. This program essentially combines the requirements of the two programs described above. Some students choose to take an extra year to complete this program; however, the program may be completed in four years with careful planning.

4. Specialist Program in Environment and Toxicology. This program is jointly sponsored by the Department of Pharmacology and Toxicology and the Centre for Environment, and examines the effects of chemicals not only on the health and behaviour of human beings but on whole ecosystems. The toxicities associated with therapeutic and environmental chemicals are discussed. Students may choose to participate in independent research projects and/or the Professional Experience Year Internship (see below). For additional information see “Centre for Environment” (www.environment.utoronto.ca) or consult our website: www.pharmtox@utoronto.ca

5. Major Programs in Pharmacology and in Biomedical Toxicology. These programs are intended for students who want to gain knowledge in either Pharmacology or Biomedical Toxicology in combination with a different and complementary area of study. A double major program allows students to experience broad, multidisciplinary training that may be of interest to students interested in pursuing further studies in professional health science programs. With the exception of the Double Specialist Program, students are not allowed to enroll concurrently in more than one of the offered programs in this Department.

For further information about registration and courses, consult the A&S Registration Handbook and Timetable, and visit our website at: www.pharmtox.utoronto.ca.

Undergraduate Office - General Inquiries:
Medical Sciences Building, Room 4207 (416-978-2728)

Undergraduate Coordinator:
Dr. M. Arnot, Medical Sciences Building, Room 4219 (416-978-3164)

Pharmacology and Toxicology Programs

The Professional Experience Year (PEY) Internship is a 12-16 month project-based, paid employment placement at pharmaceutical/biotechnology/chemical companies, university research labs, university-affiliated organizations, consulting companies, or governmental research agencies. It takes place between the 3rd and 4th years of undergraduate study and is open to Specialists in Pharmacology, Biomedical Toxicology, Environment and Toxicology with a minimum 3.0 GPA. The internship provides real-world experience in pharmaceutical development, project management, client relations, clinical research, information management and regulatory affairs.

Pharmacology Specialist (Science program)

This is a limited enrolment subject POSt that can only accommodate a limited number of students. Eligibility will be competitive and based on a student’s marks in the 3.0 required first-year courses:

BIO120H1, BIO130H1, (CHM138H1, CHM139H1)/CHM151Y1, and 1.0 FCE from (MAT135H1, MAT136H1)/MAT135Y1/MAT137Y1/MAT157Y1/(PHY131H1, PHY132H1)/(PHY151H1, PHY152H1) with an average of at least 70% on these 3.0 full-course equivalents (FCEs) and a final mark of at least 60% in each course.

While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = mid 80s; average = mid 80s.

Achieving these estimated marks does not guarantee admission to the subject POSt in any given year.

Note: Students must apply to this program on the Arts & Science Faculty Registrar’s Office website (see the Registration Handbook & Timetable for instructions).

Students wishing to enroll after their second year who have taken PCL201H1 will be considered on a case by case basis. Successful completion of required pre-requisite courses is required to further enroll in upper level program courses.

(15 full courses or their equivalent, including at least three 400-series courses)

First Year:
Required: BIO120H1; BIO130H1; CHM138H1; CHM139H1 (or CHM151Y1); MAT135H1; MAT136H1* (or MAT137Y1 or MAT157Y1); PHY131H1; PHY132H1*(or PHY151H1,PHY152H1*)

Second Year:
Required: BCH210H1; BIO230H1/(BIO240H1,BIO241H1); BIO260H1/HMB265H1; CHM247H1/CHM249H1; PCL201H1; (PSL300H1, PSL301H1)/PSL302Y1 (NOTE: PSL201Y1 is not acceptable)
Elective: PCL285H1 (We recommend completion of this course prior to the 3rd year of study. Note 1)

Third Year:
Required: BCH311H1/CSB349H1; PCL302H1; PCL376H1; PSL372H1

Fourth Year:
Required: PCL470Y1; PCL471Y1; PCL472Y1 (see NOTE 2)

Third or Fourth Year Electives:
Two and one half full-credit equivalents with at least one and half full-credit equivalent from PCL courses: ANA300Y1/BCH340H1/BCH370H1/CSB328H1/PCL362H1/PCL389H1/PCL475Y1 (see NOTE 3)/PCL477H1

NOTES
* This course may be taken in the second year and must be completed prior to the third year of the program.

1. This elective course will count towards the 2.5 FCE electives which are required for your program.
2. Enrollment in the Research Project Course (PCL472Y1) is limited and requires permission from the Department of Pharmacology and Toxicology. Students must receive prior consent of an approved supervisor according to departmental guidelines before the Department of Pharmacology and Toxicology will register them in the course. It is the student’s responsibility to initiate all necessary preparations before the session starts (see course description).
3. PCL475Y1 counts as a half credit towards the program requirement.

Pharmacology Major (Science Program)

This is a limited enrolment subject POSt that can only accommodate a limited number of students. Eligibility will be competitive and based on a student’s marks in the 3.0 required first-year courses:

BIO120H1, BIO130H1, (CHM138H1, CHM139H1)/CHM151Y1, and 1.0 FCE from (MAT135H1, MAT136H1)/MAT135Y1/MAT137Y1/MAT157Y1/(PHY131H1, PHY132H1)/(PHY151H1, PHY152H1) with an average of at least 70% on these 3.0 full-course equivalents (FCEs) and a final mark of at least 60% in each course.

While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = low 80s; average = low 80s.

Achieving these estimated marks does not guarantee admission to the subject POSt in any given year.

Note: Students must apply to this program on the Arts & Science Faculty Registrar’s Office website (see the Registration Handbook & Timetable for instructions).

Students wishing to enroll after their second year who have taken PCL201H1 will be considered on a case by case basis. Successful completion of required pre-requisite courses is required to further enroll in upper level program courses.

(8 full courses or their equivalent, including two 300-series courses and one 400-series course.)

First Year:
Required: BIO120H1; BIO130H1; CHM138H1; CHM139H1 (or CHM151Y1)

Second Year:
Required: BCH210H1; BIO230H1/(BIO240H1, BIO241H1); PCL201H1; CHM247H1/CHM249H1; (PSL300H1, PSL301H1)/PSL302Y1* (*NOTE: PSL201Y1 is not acceptable)
Elective: PCL285H1 (We recommend completion of this course prior to the 3rd year of study. Note 1)

Third Year:
Required: PCL302H1; BCH311H1/CSB349H1 (see NOTE 2)

Fourth Year:
Required: PCL470Y1

Third or Fourth Year Electives:
One full course equivalent with at least 0.5 full-credit equivalents from PCL courses: ANA300Y1/ANA301H1/BCH370H1/PCL362H1/PCL389H1/PCL475Y1 (see NOTE 3)/PCL477H1

NOTES
1. This elective course will count towards the 1.0 FCE electives which are required for your program.
2. CSB349H1 requires BIO260H1/HMB265H1 as a prerequisite.
3. PCL475Y1 counts as a half credit towards the program requirement.
4. Students are not allowed to enroll concurrently in the Major Program in Pharmacology and the Major Program in Toxicology.
5. Students are not allowed to enroll concurrently in the Major Program in Pharmacology and a Specialist Program in Toxicology.
6. Students are not permitted to take PCL472Y1 or PCL474Y1.

Biomedical Toxicology Specialist (Science program)

(15 full courses or their equivalent, including at least two and a half 400-series courses)

First Year:
Required: BIO120H1; BIO130H1; CHM138H1; CHM139H1 (or CHM151Y1); MAT135H1;MAT136H1* (or MAT137Y1 or MAT157Y1); PHY131H1;PHY132H1*(or PHY151H1, PHY152H1*)

Second Year:
Required: BCH210H1; BIO230H1/(BIO240H1,BIO241H1); BIO260H1/HMB265H1; CHM247H1/CHM249H1; PCL201H1; (PSL300H1, PSL301H1)/PSL302Y1 (PSL201Y1 is not acceptable)
Elective: PCL285H1 (We recommend completion of this course prior to the 3rd year of study. Note 1)

Third Year:
LMP363H1; PCL302H1; PCL362H1; PCL365Y1; PCL376H1

Fourth Year:
LMP301H1; PCL473Y1; PCL474Y1 (see NOTE 2); PCL481H1.

Third or Fourth Year Electives:
One and a half full-credit equivalent from: ANA301H1/BCH370H1/CHM310H1/GGR409H1/PCL389H1/PCL470Y1/PCL475Y1 (see NOTE 3)/PCL477H1

NOTES
* This course may be taken in the second year and must be completed prior to the third year of the program.
1. This elective course will count towards the 1.5 FCE electives which are required for your program.
2. Enrollment in the Research Project Course (PCL474Y1) is limited and requires permission from the Department of Pharmacology and Toxicology. Students must receive prior consent of an approved supervisor according to departmental guidelines before the Department of Pharmacology and Toxicology will register them in the course. It is the student’s responsibility to initiate all necessary preparations before the session starts (see course description).
3. PCL475Y1 counts as a half credit towards the program requirement.

Biomedical Toxicology Major (Science program)

This is a limited enrolment subject POSt that can only accommodate a limited number of students. Eligibility will be competitive and based on a student’s marks in the 3.0 required first-year courses:

BIO120H1, BIO130H1, (CHM138H1, CHM139H1)/CHM151Y1, and 1.0 FCE from (MAT135H1, MAT136H1)/MAT135Y1/MAT137Y1/MAT157Y1/(PHY131H1, PHY132H1)/(PHY151H1, PHY152H1) with an average of at least 70% on these 3.0 full-course equivalents (FCEs) and a final mark of at least 60% in each course.

While it is difficult to predict what will be competitive course marks and average in a given year, based on previous years, the estimate is: course marks = low 80s; average = low 80s.

Achieving these estimated marks does not guarantee admission to the subject POSt in any given year.

Note: Students must apply to this program on the Arts & Science Faculty Registrar’s Office website (see the Registration Handbook & Timetable for instructions).

Students wishing to enroll after their second year who have taken PCL201H1 will be considered on a case by case basis. Successful completion of required pre-requisite courses is required to further enroll in upper level program courses.

(8 full courses or their equivalent, including two 300-series courses and one 400-series course).

First Year:
Required: BIO120H1; BIO130H1; CHM138H1; CHM139H1 (or CHM151Y1)

Second Year:
Required: BCH210H1; BIO230H1/(BIO240H1,BIO241H1); PCL201H1; CHM247H1/CHM249H1; (PSL300H1, PSL301H1)/PSL302Y1 ( PSL201Y1 is not acceptable)
Elective: PCL285H1 (We recommend completion of this course prior to the 3rd year of study. Note 1)

Third Year:
Required: PCL302H1; PCL362H1 (see NOTE 2)

Fourth Year:
Required: PCL473Y1

Third or Fourth Year Electives:
One full-course equivalent with at least 0.5 full-credit equivalents from PCL courses: BCH370H1/LMP301H1/LMP363H1/PCL389H1/PCL470Y1/PCL475Y1(see NOTE 3)/PCL477H1/PCL481H1

NOTES
1. This elective course will count towards the 1.0 FCE electives which are required for your program.
2. Although LMP301H1 (Introduction to the Biochemistry of Human Disease) and LMP363H1 (Principles of Pathobiology) are not prerequisites to enroll in PCL473Y1, students are recommended to enroll in at least one of these courses.
3. PCL475Y1 counts as a half credit towards the program requirement.
4. Students are not allowed to enroll concurrently in the Major Program in Toxicology and the Major Program in Pharmacology.
5. Students are not allowed to enroll concurrently in the Major Program in Toxicology and a Specialist Program in Pharmacology.
6. Students are not permitted to take PCL472Y or PCL474Y.

Double Specialist in Pharmacology and Biomedical Toxicology (Science program)

(18 full courses or their equivalent)

This program requires completion of both the Pharmacology and Toxicology Specialist courses and may require an extra year for completion.Students are allowed to enroll in only one of the two project courses (PCL472Y1/PCL474Y1) and only one of the two PCL laboratory courses (PCL365Y1/PCL471Y1) offered by the Department of Pharmacology and Toxicology.

First Year:
Required: BIO120H1; BIO130H1; CHM138H1; CHM139H1 (or CHM151Y1); MAT135H1;MAT136H1* (or MAT135Y1); PHY131H1;PHY132H1*(or PHY151H1,PHY152H1*)

Second Year:
Required:BCH210H1; BIO230H1/(BIO240H1,BIO241H1); BIO260H1/HMB265H1; CHM247H1/CHM249H1; PCL201H1; (PSL300H1, PSL301H1)/PSL302Y1 (NOTE: PSL201Y1 is not acceptable)
Elective: PCL285H1 (We recommend completion of this course prior to the 3rd year of study. Note 1)

Third Year:
Required: BCH311H1/CSB349H1; LMP363H1; PCL302H1; PCL362H1; PCL365Y1 (see NOTE 2); PCL376H1; PSL372H1

Fourth Year:
Required: LMP301H1; PCL470Y1; PCL471Y1 (see NOTE 2); PCL473Y1; PCL472Y1/PCL474Y1 (see NOTE 3), PCL481H1

Third or Fourth Year Electives:
Two full-credit equivalents with at least 1.0 full-credit equivalents from PCL courses: ANA300Y1/ANA301H1/BCH340H1/BCH370H1/CHM310H1/CSB328H1/GGR409H1/ PCL389H1/PCL475Y1 (see NOTE 4)/PCL477H1

NOTES
* This course may be taken in the second year and must be completed prior to the third year of the program.
1. This elective course will count towards the 2.0 FCE electives which are required for your program.
2. Students may either take PCL365Y1 or PCL471Y1.
3. Enrollment in the Research Project Course (PCL472Y1/474Y1) is limited and requires permission from the Department of Pharmacology and Toxicology. Students must receive prior consent of an approved supervisor according to departmental guidelines before the Department of Pharmacology and Toxicology will register them in the course. It is the student’s responsibility to initiate all necessary preparations before the session starts (see course description).
4. PCL475Y1 counts as a half credit towards the program requirement.

Environment & Toxicology Specialist (Science Program)

This program is jointly sponsored by the Department of Pharmacology and Toxicology and the Centre for Environment. The Environment and Toxicology program examines the effects of chemicals not only on the health and behaviour of human beings but on whole ecosystems. The toxicities associated with therapeutic and environmental chemicals are discussed. Students may choose to participate in independent research projects and/or the Professional Experience Year Internship (PEY). This program prepares students for advanced graduate study and research in environmental toxicology, and for consultative positions in governmental agencies and industry. Students interested in biomedical toxicology (the adverse effects of chemicals on human health) should consider enrolling in the Specialist Program in Biomedical Toxicology offered by the Department of Pharmacology & Toxicology.

For further information please consult David Powell, Undergraduate Student Advisor, Centre for Environment, Room 1049A, Earth Sciences Centre, 416-946-8100 david.powell@utoronto.ca or go to www.pharmtox.utoronto.ca. For information about PEY, go to www.pharmtox.utoronto.ca

This is a limited enrolment subject POSt that can only accommodate a limited number of students. Eligibility will be based on a student’s mark(s) in the required course(s). The precise mark thresholds outlined below are an estimate of what will be required in the coming POSt admission cycle. Achieving those mark(s) does not necessarily guarantee admission to the POSt in any given year.

Admission will be determined by a student’s average in BIO120H1, BIO130H1, CHM138H1, CHM139H1, and one of PHY131H1, MAT135H1, or GGR100H1. It is expected that a cumulative average of approximately 70% in the selected courses will be required for admission; however, achieving that mark does not necessarily guarantee admission to the program in any given year. Students wishing to enroll after their second year who have taken PCL 201H will be considered on a case by case basis. Successful completion of required pre-requisite courses is required to further enroll in upper level program courses. Entry into the program requires completion of BIO120H1, BIO130H1; CHM138H1, CHM139H1, one of PHY131H1, MAT135H1, or GGR100H1 and 0.5 FCE from among the other first year course requirements. Completion of the program requires completion of all 4 FCE of the first year required courses.

(15 full courses or their equivalent; must include at least four 300+-series courses, one of which must be at the 400-level)

First Year:
1. BIO120H1; BIO130H1; CHM138H1; CHM139H1
2. At least one of PHY131H1; MAT135H1; or GGR100H1
3. At least 1.5 FCE from GGR100H1 (if not counted in 2 above); GGR101H1; MAT135H1(if not counted in 2 above); MAT 136H1/(MAT135Y1)/JMB170Y1; PHY131H1(if not counted in 2 above); PHY132H1

Second Year:
1. BCH210H1; BIO220H1, BIO230H1/(BIO240H1, BIO241H1); ENV221H1; ENV222H1/GGR222H1; ENV234H1; PCL201H1
2. One FCE from (BIO270H1, BIO271H1)/(PSL300H1, PSL301H1)/PSL302Y1 (see Note 1 below)
3. CHM247H1

Third and Fourth Years:
1. JGE321H1; ENV334H1; CHM210H1/ENV235Y1 (see Note 2 below)
2. PCL302H1; PCL362H1
3. One from PCL376H1/STA220H1/STA221H1/EEB225H1 (see Note 3 below)
4. PCL473Y1
5. One from ENV421H1/PCL365Y1/PCL474Y1 (see Note 3 below)
6. At least one full course equivalent from: ENV341H1, ENV235H1/ENV235Y1; JGE236H1; CHM310H1; GGR409H1; PCL477H1, PCL481H1; LMP301H1, LMP363H1 (see Note 4, below)

NOTES:
1. PSL300H1 requires PHY131H1.
2. Students who have taken ENV235Y1 can count it as CHM210H1 for the Third and Fourth year Requirement 1 and as a half FCE towards Third and Fourth year requirement 6.
3. PCL201H1, PCL302H1 and PCL376H1 are pre/co-requisites for students intending to take PCL474Y1. Students intending to take PCL474Y1 must obtain permission from the Undergraduate Student Advisor of the Centre for Environment 3 months prior to the intended date of enrolment. Students must also consult with the Department of Pharmacology and Toxicology at least 3 months prior to the intended date of enrolment as the student is responsible for arranging for a supervisor. PCL302H1 and PCL376H1 are required co-requisites for PCL365Y1. Students taking ENV421H must take 1.5 FCE from Group 6 in order to have 15 FCE of program credits.
4. Students taking PCL481H1 must take BCH210H1, PCL302H1 and PCL362H1 as prerequisites and must take BCH210H1 prior to PCL477H1.

Pharmacology and Toxicology Courses

First Year Seminars

The 199Y1 and 199H1 seminars are designed to provide the opportunity to work closely with an instructor in a class of no more than twenty-four students. These interactive seminars are intended to stimulate the students’ curiosity and provide an opportunity to get to know a member of the professorial staff in a seminar environment during the first year of study. Details here.

PCL102H1 The Art of Drug Discovery[24L]

This course introduces students to the processes and strategies for discovering new drugs with a special focus on current and emerging approaches for the rational design of drugs that are both effective and safe.

Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL201H1 Introduction to Pharmacology and Pharmacokinetic Principles[36L/6T]

A general introduction to the principles of pharmacology and pharmacokinetics. Topics include chemical (drug) absorption, distribution, biotransformation, elimination; the calculation of dosages and pharmacokinetic parameters, variability in drug response, adverse drug reactions and special interest topics.

Corequisite: Recommended Co-requisites: BIO230H1/(BIO240H1, BIO241H1), CHM247H1/CHM249H1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL285H1 Effective Writing in Life Science[36L]

This course focuses on developing reading, writing and communication skills as applied to Pharmacology, Toxicology and the related biomedical and life sciences. Students will develop analytical and critical thinking skills while learning to develop es-says/reviews and to evaluate discipline-specific data and readings.

Prerequisite: BIO120H1, BIO130H1, CHM138H1, CHM139H1
Distribution Requirement Status: This is a Humanities or Science course
Breadth Requirement: None

PCL299Y1 Research Opportunity Program

Credit course for supervised participation in faculty research project. Details here.

Distribution Requirement Status: This is a Science course
Breadth Requirement: None

PCL302H1 Pharmacodynamic Principles[36L]

Topics include biological action of drugs on membranes, enzymes, receptors, neural and hormonal systems, transmission and modulation.

Prerequisite: BIO230H1/(BIO240H1, BIO241H1), CHM247H1/CHM249H1, (PSL300H1, PSL301H1)/PSL302Y1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL362H1 Introductory Toxicology[27L/5T]

Toxicological problems encountered in animals and humans; biochemical mechanisms and clinical factors of toxicological significance; models of drug-related diseases.

Prerequisite: BCH210H1, BIO230H1/(BIO240H1, BIO241H1), CHM247H1/CHM249H1, PCL201H1, PCL302H1 or Permission of the Course Coordinator
Corequisite: Recommended Co-requisite: BCH311H1/CSB349H1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL365Y1 Toxicology Laboratory[48T/48P]

A hands-on laboratory course exploring a wide variety of modern experimental techniques currently utilized in toxicology. This course will provide the experimental theory of how the techniques work and their advantages and disadvantages, while additionally allowing students to perform these techniques in the process of addressing toxicological problems. Enrollment in this course is generally restricted to students enrolled in the Biomedical Toxicology Specialist, Pharmacology and Toxicology Double Specialist, and Environment and Toxicology Specialist programs.

Prerequisite: PCL201H1
Corequisite: PCL302H1, (PSL300H1, PSL301H1)/PSL302Y1, PCL362H1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL376H1 Experimental Design and Data Analysis for Pharmacology and Toxicology[36L]

A practically oriented course, focused on experimental design and the analysis of pharmacological and toxicological data. Topics include: principles of experimental design, data analysis and statistical tests appropriate for each type, use of computing statistical packages, analysis of dose-response and time-response curves and analysis of receptor binding assays.

Prerequisite: PCL201H1
Corequisite: PCL302H1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL389H1 Understanding the Role of Pharmacology and Toxicology in Society[24L]

This service learning course explores issues surrounding the effects that pharmaceuticals and chemicals have in society. Specifically, it integrates pharmacology with social, health and political issues as they relate to drug abuse and addiction. Students are required to interact and work with community partners during the semester. Classroom discussions will integrate community experiences with lecture material.

Prerequisite: PCL201H1
Corequisite: PCL302H1; (PSL300H1, PSL301H1)/PSL302Y1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL470Y1 Systems Pharmacology[61L/9S]

Concepts of drug properties and their interactions within the body. Mechanism of action, pharmacological properties and clinical use of drugs acting on the autonomic and central nervous systems, cardiovascular, renal, respiratory, gastrointestinal, immunological and endocrine systems; therapuetic use of endogenous compounds; antimicrobial and anti-inflammatory drugs, chemotherapy, pharmacogenomics. Critical evaluation of primary literature and examination of clinical case studies will be integrated with lecture material.

Prerequisite: BCH210H1, PCL201H1, PCL302H1, (PSL300H1, PSL301H1)/PSL302Y1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL471Y1 Pharmacology Laboratory[40T/56P]

Demonstrations, seminars, and laboratory exercises in selected areas of pharmacology. Enrollment in this course is generally restricted to students enrolled in the Pharmacology Specialist and Double Specialist programs.

Prerequisite: PSL372H1, PCL201H1, PCL302H1
Corequisite: PCL470Y1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL472Y1 Project in Pharmacology [TBA]

This course affords students an opportunity for hands-on research experience in a laboratory or applied pharmacology setting. Students will work under the supervision of a faculty member and will submit a final written report. Enrollment is limited and requires permission from the Department of Pharmacology and Toxicology. It is the student’s responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors can be obtained from the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department of Pharmacology and Toxicology) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology. Students are expected to spend approximately 200 hours towards this project but this will be project/supervisor dependent.

Prerequisite: PCL201H1, PCL302H1, PCL376H1 and permission of Department
Exclusion: PCL474Y1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL473Y1 Interdisciplinary Toxicology[48L]

This course explores several contemporary topics in biomedical and environmental toxicology with emphasis on how chemicals affect human health. Lectures cover principles of toxicology, the mechanisms of toxicity of a wide variety of toxic agents and the associated toxicities, methodologies used to examine chemical toxicities, risk assessment, and the applications of toxicology.

Prerequisite: BCH210H1, PCL201H1, PCL302H1, PCL362H1 or Permission of the Course Coordinator
Recommended Preparation: BCH311H1/CSB349H1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL474Y1 Project in Toxicology [TBA]

This course affords students an opportunity for hands-on research experience in a laboratory or applied toxicology setting. Students will work under the supervision of a staff member and will submit a final written report. Enrollment is limited and requires permission from the Department of Pharmacology and Toxicology. It is the student’s responsibility to secure a placement with an approved supervisor before the course begins (a list of potential supervisors can be obtained from the Department of Pharmacology and Toxicology). Students will be registered in the course once their ballot form (obtained from the Department of Pharmacology) is signed by an approved supervisor and approved by the Department of Pharmacology and Toxicology. Students are expected to spend approximately 200 hours towards this project but this will be project/supervisor dependent.

Prerequisite: PCL201H1, PCL302H1, PCL376H1 and permission of Department
Exclusion: PCL472Y1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL475Y1 Neuropsychopharmacology[72L/24T]

Major neuro-psychiatric disease syndromes: clinical pathology and neuronal abnormalities; CNS drugs: theories and mechanisms of action.

Prerequisite: Enrollment is limited to students with a minimum cGPA of 3.0.
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL477H1 The DNA Damage Response in Pharmacology and Toxicology[24L]

Many anticancer drugs and environmental agents exert their cytotoxic effects through DNA damage. This course explores specific pharmacological and toxicological agents that damage DNA and discusses how mammalian cells respond to this DNA damage.

Prerequisite: BCH210H1/BCH242Y1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)

PCL481H1 The Molecular and Biochemical Basis of Toxicology[24L]

The biochemical principles and molecular mechanisms underlying the toxicity of drugs and foreign agents. The sequence of events at the molecular level leading to impairment of cell function and the factors which determine and affect toxicity.

Prerequisite: PCL302H1, PCL362H1, BCH210H1
Distribution Requirement Status: This is a Science course
Breadth Requirement: Living Things and Their Environment (4)