Laboratory Medicine and Pathobiology Courses |
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First Year Seminars The 199Y1 and 199H1 seminars are designed to provide the opportunity to work closely with an instructor in a class of no more than twenty-four students. These interactive seminars are intended to stimulate the students’ curiosity and provide an opportunity to get to know a member of the professorial staff in a seminar environment during the first year of study. Details here. LMP299Y1 Credit course for supervised participation in faculty research project. Details here. LMP300Y1 Concepts in pathogenesis; cell injury and death; tissue structure, wound healing; repair and fibrosis. Molecular basis of major organ system pathology. The laboratory examines gross anatomical specimens and introduces histopathology. Enrolment is limited to students specializing in pathobiology who have completed the first and second year requirements of the program. LMP301H1 Introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions. The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained. Not intended for students in the Pathobiology Specialist program. LMP363H1 Pathological changes brought on by foreign compounds; applications of pathology to the detection of toxic carcinogenic actions. LMP365H1 A general introduction to the cellular and molecular aspects of cancer and its etiology. The laboratory component presents the range of benign and malignant tumor types at the gross and histological levels. Pathophysiology of cancer, invasion and metastases, role of the immune system. LMP402H1 Cellular and molecular components of the inflammatory response. Activation of the inflammatory response by viral and microbial pathogens. Tissue pathology resulting from the inflammatory response. Evolution of pathogens to avoid and exploit the response. LMP403H1 The immune system in disease. Responses of the immune system to host invasion, injurious stimuli, and transplantation. Immunopathology of organ-specific diseases including pancreas, gut, liver, heart, kidney, and blood. Intended for students specializing in pathobiology or related programs. LMP404H1 Molecular and cellular architecture of connective tissue in health and in diseases, such as osteoporosis and arthritis. Cellular and endocrine signals necessary for formation and maintenance of the skeleton. Biomechanics and tissue engineering of bone and cartilage. Selected other connective tissue diseases, their genetic variability, and up-to-date treatment strategies. LMP405Y1 A self-contained research project to be completed under the supervision of a faculty member. The main areas of research are as listed in the description of the Department (above). The student will normally have completed three full years of study, and is expected to devote at least one full day per week to the project. Admission is by arrangement with the Department and with a particular supervisor. A list of potential supervisors is available from the Departmental Office and on our web site. LMP406H1 Pathobiology of the heart, blood vessels, and lymphatic system. Congenital diseases of the heart, ischemic injury, stroke. Treatments of vascular disease and cardiovascular biomaterials. Major focus on atherosclerosis and hypertension. The emphasis is on the underlying cell biology of these processes. LMP410H1 Molecular basis of neurodegenerative diseases of the central and peripheral nervous systems. Relevant neuroanatomy and molecular biology of the CNS. Current research topics in neurodegenerative diseases. LMP412H1 The lymphatic circulation plays an important role in the maintenance of tissue fluid balance, cancer metastases, and delivery of antigens to lymph nodes where immune responses are generated. This course examines the role of lymphatic vessel in disease and potential new molecular therapies to treat lymphatic pathology. LMP415H1 A thematic review of the major scientific areas and research controversies in forensic medicine. The approach is mechanistic analysis and evidence-based medicine. Classical forensic medicine is critically analyzed with emphasis on experimental meth-ods to resolve controversies. We also explore how the justice system utilizes medical and scientific data. LMP436H1 Molecular mechanism involved in pathogenesis of infectious disease. Topics include recurrent themes in the establishment of infectious disease, such as adherence and spread of pathogenic bacteria as well as evasion of host defences. Emphasis is placed on genetic characterization and expression of virulence determinants and on interactions between bacterial pathogens and their hosts. |