Molecular Genetics and Microbiology Courses |
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The 199Y1 and 199H1 seminars are designed to provide the opportunity to work closely with an instructor in a class of no more than twenty-four students. These interactive seminars are intended to stimulate the students’ curiosity and provide an opportunity to get to know a member of the professorial staff in a seminar environment during the first year of study. Details here. MGY299Y1 Credit course for supervised participation in faculty research project. Details here. MGY311Y1 DNA replication, DNA repair and mutation, recombination, transcription, RNA modification and processing, the genetic code and tRNA, translation, regulation of gene expression, development and differentiation, molecular evolution. MGY312H1 Laboratory experiments in genetics of model organisms. Topics studied include Mendelian genetics, linkage and recombination, complementation, analysis of chromosome rearrangements, mutant selection and analysis, and genetic crosses in bacteria, yeast, and fruit flies. MGY350H1 The course examines concepts of genetics in the context of human development, disease and evolution. Topics include genetic interactions and complex traits, variation in disease phenotype, signalling and development, stem cells and epigenetic regulation. MGY376H1 Fundamental laboratory techniques in bacteriology, bacterial genetics and virology, including immunologically-based assays. Topics may include biofilms, molecular-based identification of bacteria and expression of reporter genes from viral vectors. Valuable not only for students in Microbiology but also for those in related disciplines which make use of bacteria and viruses as research tools. Open to students in related programs. MGY377H1 Detailed study of bacteria in terms of structure, classification and replication. Basis for advanced study in various aspects of bacteriology including bacterial physiology, bacterial genetics, molecular pathogenesis of disease and environmental studies. MGY378H1 Detailed study of viruses in terms of structure, classification, replication and interaction with the host. Basis for advanced study in virology. Requires some familiarity with immunology. A concurrent course in immunology (IMM334Y1/IMM335Y1) is recommended. MGY420H1 This course describes regulatory mechanisms controlling gene expression in prokaryotes and eukaryotes. The lectures are designed to promote discussion of various experimental approaches. Topics include: assembly of a transcription complex; initiation of transcription; role of sigma factors and transcription factors; role of regulators of transcription; regulation of SV40 transcription; lambda antitermination; antitermination in HIV-1. MGY425H1 This course presents and integrates molecular aspects of signal transduction and cell cycle regulation in eukaryotic cells from yeast to humans. Emphasis is on recent advances in growth factor receptor signalling, modular protein domains, and the recurrent role of protein phosphorylation and protein-protein interactions in cell regulation. MGY428H1 A broad ranging course that covers many aspects of genomics, which is the discipline of defining and attributing function to all of the heritable material of an organism on a genome-wide scale, as applied to microbes, invertebrates and vertebrates. The primary and review literature will be the basis of all lectures. MGY432H1 Laboratory experiments demonstrating basic and advanced molecular biological methods applied to molecular genetics and microbiology. MGY434H1 How bacteria sense their environment and signal to regulatory systems when to adapt to environmental stimuli. Topics discussed include the bacterial cell cycle, carbon/energy metabolism, catabolite repression, bacterial development, sporulation, stress responses, regulatory two-component systems and quorum sensing. MGY440H1 Analysis of virus/host interactions at the molecular level with a view to understanding how viruses cause disease. Course material is based on recent research publications. Topics may include: virus entry and intracellular trafficking, activation of host cell signalling pathways, viral and host determinants of tissue tropism within the host and transmission between hosts. MGY445H1 Current approaches to gene therapy including design of virus-based vectors for delivery and expression of effector genes. Emphasis on the use of retrovirus-based strategies for prevention and treatment of HIV infection. MGY451H1 Basic and advanced principles of genetic analysis applied to the study of two of the best-understood eukaryotic model organisms: the yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans. We emphasize the use of genetic approaches to address problems in cell biology and development, such as the regulation of cell fate. Much of the knowledge gained from these simple organisms has proven broadly applicable, and the same principles of developmental genetic analysis underlie efforts to understand the development of more complex organisms. MGY452H1 This companion course to MGY451H1 moves on to cover the more complex animal models of development and disease - the fruit fly, zebrafish and mouse. Advanced genetic principles and approaches used in the study of these animals are introduced, and applied to highly conserved genetic and molecular processes that give rise to common structures such as the limbs, nervous system and eyes. Students completing this course should be able to understand and evaluate any study that makes use of these three major model systems. MGY470H1 Current aspects of human and molecular genetics including: chromosome structure and function, inheritance of mutations and disease, the human genome and disease gene mapping, cancer genetics, mouse disease models and gene based diagnostics and therapies. MGY480Y1 An opportunity for specialized individual research in molecular genetics and microbiology by arrangement with the course coordinator. MIJ485H1 Analysis of infectious disease vaccines, and pathogens’ strategies to evade specific immune response, with an emphasis on molecular and immunological aspects. Special topics include: molecular basis of pathogenicity and immune-evasion strategies; vaccination strategies; adverse effects of vaccines (given jointly by the Departments of Molecular Genetics and Immunology). |