BCB410H1
Applied Bioinformatics 26L, 13P
Practical introduction to concepts, standards and tools for the implementation of strategies in bioinformatics and computational biology.
Prerequisite: CSC263H1, CSC373H1, MGY311Y1/ (BIO260H1, BIO349H1) or special permission
BCB420H1
Computational Systems Biology 26L
Current approaches to using the computer for modeling biology as integrated molecular systems.
Prerequisite: CSC263H1, CSC373H1 MGY311Y1 / (BIO260H1, BIO349H1) or special permission
BCB430Y1
Special Project in Bioinformatics and Computational Biology TBA
An opportunity for specialized individual research in bioinformatics and computational biology by arrangement with the course coordinator and a supervisor.
Prerequisite: GPA 3.0 and written acceptance by coordinator and supervisor.
Corequisite: BCB410H1, BCB420H1
Exclusion: Any other 4th year special project course taken at the same time.
Biochemistry Courses
NOTE
 CHM1**Y1
(transfer credit) with course exclusion to CHM138H1 AND CHM139H1 meet the
prerequisite requirement for BCH210H/BCH242Y.
BCH299Y1
Research Opportunity Program
Credit course for supervised participation in faculty research project. See page 45 for details.
BCH210H1
Introductory Biochemistry 39L, 26T
An introductory course in biochemistry covering proteins, enzymes, and metabolism. This course is intended for students who are NOT taking BCH242Y1 as part of their program.
Exclusion: BCH242Y1/310H1/320Y1/321Y1/CHM265H5(UTM)/ 361H5(UTM)/362H5(UTM)
Prerequisite: (CHM138H1, CHM139H1)/CHM151Y1
BCH242Y1
Biochemistry 78L
An introduction to biochemistry for students specializing in biochemistry and related specialist programs. The major topics include protein structure, enzyme mechanisms, carbohydrates, metabolism and bioenenergetics, lipids, membranes, structure of DNA and RNA.
Exclusion: BCH210H1/310H1/320Y1/321Y1/CHM265H5(UTM)/ 361H5(UTM)/362H5(UTM)
Prerequisite: (CHM138H1, CHM139H1)/CHM151Y1
BCH304H1
Cell Dynamics & Interactions 28L, 11T
Principles and concepts of cell biology; structure, molecular organization and dynamic cell-cell and cell-extracellular matrix interactions during cell migration, cell adhesion, cell polarity and tissue organization and the role of cytoskeletal components and cell surface receptors in these processes. Approaches and imaging techniques used; contributions of cell biology to advances in medicine.
Exclusion: ANA304Y1
Prerequisite: BIO250Y1, BCH210H1/BCH242Y1
BCH335H1
Nucleic Acids and Recombinant DNA Technology 39L
Structure of DNA and RNA. Catalytic RNAs (ribozymes). Aspects of DNA topology and chromatin structure. Restriction/modification and fundamentals of recombinant DNA technology.
Exclusion: BCH430H1
Prerequisite: BCH242Y1
BCH340H1
Proteins: from Structure to Proteomics 39L
Proteins are the main functional units of the cell. In this course, a detailed overview of protein structure, stability, folding, and protein-ligand interactions will be given with strong emphasis on discussing the basic principles in the field. Biophysical methods as well as theoretical approaches to studying protein stability and folding will be presented. Finally, proteomics approaches to map protein-protein interactions will be discussed.
Exclusion: BCH421H1
Prerequisite: BCH242Y1
BCH370H1
Laboratory Course in Biochemical Techniques 13L,
39P
Techniques in biochemical research and analytical laboratories. Intended for students who are not proceeding further in biochemistry. It is highly recommended that students take this course in their third year as space is limited and priority will go to third-year students. No enrolment will be permitted five days after the start of class. (Enrolment limited)
Exclusion:: BCH371H1, CHM379H1
Prerequisite: BCH210H1
BCH371H1
A Laboratory Course in Biochemistry 75P
An introduction to laboratory techniques of modern biochemistry. Experiments illustrate and develop the concepts described in lecture courses, and prepare the student for advanced training in biochemical laboratory techniques. (Enrolment limited)
Exclusion: BCH370H1, CHM379H1
Prerequisite: BCH242Y1
Note
Students who have completed University of Toronto at Mississauga’s
CHM361H5 and 362H5 may enrol in 400-series lecture courses if they obtain permission
of the Department
BCH422H1
Membrane Proteins: Structure, and Function 26L
Structural features of membrane proteins and methods of analysis. Function of membrane proteins as transporters, channels, pumps and receptors. Molecular aspects of disease processes linked to membrane proteins.
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1
BCH425H1
Structural Biology: Principles and Practice 26L
Theory and practice of modern biophysical techniques as applied in the study of structure and function of macromolecules; emphasis on protein X-ray crystallography, NMR, and other spectroscopic methods; discussion of selected examples.
Prerequisite: BCH210H1/BCH242Y1
BCH426H1
Regulation of Signalling Pathways 26L
A variety of questions relating to signal transduction are investigated. How is calcium regulated in the cell and how does calcium regulate cell function? How are extracellular signals received and transmitted by intracellular proteins to control cellular proliferation and differentiation? What signaling paths are triggered by insulin?
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1
JBI428H1
Molecular Immunology 26L
Molecular mechanisms involved in innate and adaptive immunity
including the structure and function of immunoglobulins, the complement system, antigen processing and presentation and membrane signalling events. Emphasis is on experimental approaches and quantitative aspects. (Given jointly by the Departments of Biochemistry and Immunology)
Prerequisite: BCH210H1/BCH242Y1, IMM334Y1/IMM335Y1
Recommended preparation: BIO349H1/MGY311Y1/PSL350H1
BCH440H1
Protein Biosynthesis 26L
Mechanisms of translation initiation and translational control, ribosome assembly and structure. Protein folding and molecular chaperones. Protein targeting and transport. Regulation of protein degradation.
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1
BCH441H1
Bioinformatics 26L, 13T
This course covers the use of computers in biochemistry and molecular biology. The main topics include: structure and organization of sequence databases, genome databases, sequences alignment and search strategies, molecular evolution and methods for constructing phylogenetic trees. Recent advances in comparative genomics and proteomics are presented. Assignments focus on practical applications of web-based bioinformatics tools.
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1
BCH445H1
Organelles and Cell Function 26L
Principles and concepts of cell biology are covered including structure, biogenesis, and dynamic behaviour of cell organelles. The roles of sub-nuclear structure in DNA replication and of vesicular transport in endocytosis, exocytosis and phagocytosis are emphasized, as are modern imaging techniques and contributions of cell biology to advances in medicine.
**Please note in the past academic session this course was presented as BCH 305H1
Exclusion: ANA304Y1, BCH305H1
Prerequisite: BIO250Y1, BCH210H1/BCH242Y1
BCH471Y1
Advanced Biochemistry Laboratory 168P
Experiments demonstrating modern concepts of biochemistry and molecular biology. (Enrolment limited)
Prerequisite: (BCH335H1 + BCH340H1 + BCH371H1)/(CHM361H5 [UTM] + 362H5 [UTM] + 371H5 [UTM]) + MGY311Y1
BCH473Y1
Advanced Research Project in Biochemistry 154P
Research in a particular area of biochemistry, by arrangement with the Department and the instructor concerned. Students must have a minimum GPA of 3.0.
Prerequisite: BCH335H1 + BCH340H1 + BCH371H1, and permission of Department
Co-requisite: BCH471Y1
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