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Bioinformatics & Computational Biology Courses

Key to Course Descriptions.

For Distribution Requirement purposes, all BCB courses are classified as SCIENCE courses.

Biochemistry Courses

Key to Course Descriptions.

For Distribution Requirement purposes, all BCH courses are classified as SCIENCE courses.

| Course Winter Timetable |


BCB410H1
Applied Bioinformatics        26L, 13P

Practical introduction to concepts, standards and tools for the implementation of strategies in bioinformatics and computational biology.
Prerequisite: CSC263H1, CSC373H1, MGY311Y1/ (BIO260H1, BIO349H1) or special permission


BCB420H1
Computational Systems Biology        26L

Current approaches to using the computer for modeling biology as integrated molecular systems.
Prerequisite: CSC263H1, CSC373H1 MGY311Y1 / (BIO260H1, BIO349H1) or special permission


BCB430Y1
Special Project in Bioinformatics and Computational Biology       TBA

An opportunity for specialized individual research in bioinformatics and computational biology by arrangement with the course coordinator and a supervisor.
Prerequisite: GPA 3.0 and written acceptance by coordinator and supervisor.
Corequisite: BCB410H1, BCB420H1
Exclusion: Any other 4th year special project course taken at the same time.


Biochemistry Courses

NOTE
CHM1**Y1 (transfer credit) with course exclusion to CHM138H1 AND CHM139H1 meet the prerequisite requirement for BCH210H/BCH242Y.

BCH299Y1
Research Opportunity Program

Credit course for supervised participation in faculty research project. See page 45 for details.


BCH210H1
Introductory Biochemistry        39L, 26T

An introductory course in biochemistry covering proteins, enzymes, and metabolism. This course is intended for students who are NOT taking BCH242Y1 as part of their program.

Exclusion: BCH242Y1/310H1/320Y1/321Y1/CHM265H5(UTM)/ 361H5(UTM)/362H5(UTM)
Prerequisite: (CHM138H1, CHM139H1)/CHM151Y1


BCH242Y1
Biochemistry        78L

An introduction to biochemistry for students specializing in biochemistry and related specialist programs. The major topics include protein structure, enzyme mechanisms, carbohydrates, metabolism and bioenenergetics, lipids, membranes, structure of DNA and RNA.

Exclusion: BCH210H1/310H1/320Y1/321Y1/CHM265H5(UTM)/ 361H5(UTM)/362H5(UTM)
Prerequisite: (CHM138H1, CHM139H1)/CHM151Y1


BCH304H1
Cell Dynamics & Interactions         28L, 11T

Principles and concepts of cell biology; structure, molecular organization and dynamic cell-cell and cell-extracellular matrix interactions during cell migration, cell adhesion, cell polarity and tissue organization and the role of cytoskeletal components and cell surface receptors in these processes. Approaches and imaging techniques used; contributions of cell biology to advances in medicine.

Exclusion: ANA304Y1
Prerequisite: BIO250Y1, BCH210H1/BCH242Y1


BCH335H1
Nucleic Acids and Recombinant DNA Technology       39L

Structure of DNA and RNA. Catalytic RNAs (ribozymes). Aspects of DNA topology and chromatin structure. Restriction/modification and fundamentals of recombinant DNA technology.

Exclusion: BCH430H1
Prerequisite: BCH242Y1


BCH340H1
Proteins: from Structure to Proteomics        39L

Proteins are the main functional units of the cell. In this course, a detailed overview of protein structure, stability, folding, and protein-ligand interactions will be given with strong emphasis on discussing the basic principles in the field. Biophysical methods as well as theoretical approaches to studying protein stability and folding will be presented. Finally, proteomics approaches to map protein-protein interactions will be discussed.

Exclusion: BCH421H1
Prerequisite: BCH242Y1


BCH370H1
Laboratory Course in Biochemical Techniques        13L, 39P

Techniques in biochemical research and analytical laboratories. Intended for students who are not proceeding further in biochemistry. It is highly recommended that students take this course in their third year as space is limited and priority will go to third-year students. No enrolment will be permitted five days after the start of class. (Enrolment limited)

Exclusion:: BCH371H1, CHM379H1
Prerequisite: BCH210H1


BCH371H1
A Laboratory Course in Biochemistry        75P

An introduction to laboratory techniques of modern biochemistry. Experiments illustrate and develop the concepts described in lecture courses, and prepare the student for advanced training in biochemical laboratory techniques. (Enrolment limited)

Exclusion: BCH370H1, CHM379H1
Prerequisite: BCH242Y1



Note

Students who have completed University of Toronto at Mississauga’s CHM361H5 and 362H5 may enrol in 400-series lecture courses if they obtain permission of the Department


BCH422H1
Membrane Proteins: Structure, and Function       26L

Structural features of membrane proteins and methods of analysis. Function of membrane proteins as transporters, channels, pumps and receptors. Molecular aspects of disease processes linked to membrane proteins.
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1


BCH425H1
Structural Biology: Principles and Practice       26L

Theory and practice of modern biophysical techniques as applied in the study of structure and function of macromolecules; emphasis on protein X-ray crystallography, NMR, and other spectroscopic methods; discussion of selected examples.
Prerequisite: BCH210H1/BCH242Y1


BCH426H1
Regulation of Signalling Pathways        26L

A variety of questions relating to signal transduction are investigated. How is calcium regulated in the cell and how does calcium regulate cell function? How are extracellular signals received and transmitted by intracellular proteins to control cellular proliferation and differentiation? What signaling paths are triggered by insulin?
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1


JBI428H1
Molecular Immunology        26L

Molecular mechanisms involved in innate and adaptive immunity
including the structure and function of immunoglobulins, the complement system, antigen processing and presentation and membrane signalling events. Emphasis is on experimental approaches and quantitative aspects. (Given jointly by the Departments of Biochemistry and Immunology)
Prerequisite: BCH210H1/BCH242Y1, IMM334Y1/IMM335Y1
Recommended preparation: BIO349H1/MGY311Y1/PSL350H1


BCH440H1
Protein Biosynthesis        26L

Mechanisms of translation initiation and translational control, ribosome assembly and structure. Protein folding and molecular chaperones. Protein targeting and transport. Regulation of protein degradation.
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1


BCH441H1
Bioinformatics        26L, 13T

This course covers the use of computers in biochemistry and molecular biology. The main topics include: structure and organization of sequence databases, genome databases, sequences alignment and search strategies, molecular evolution and methods for constructing phylogenetic trees. Recent advances in comparative genomics and proteomics are presented. Assignments focus on practical applications of web-based bioinformatics tools.
Prerequisite: BCH210H1/BCH242Y1, MGY311Y1/BIO349H1/PSL350H1


BCH445H1
Organelles and Cell Function        26L

Principles and concepts of cell biology are covered including structure, biogenesis, and dynamic behaviour of cell organelles. The roles of sub-nuclear structure in DNA replication and of vesicular transport in endocytosis, exocytosis and phagocytosis are emphasized, as are modern imaging techniques and contributions of cell biology to advances in medicine.
**Please note in the past academic session this course was presented as BCH 305H1

Exclusion: ANA304Y1, BCH305H1
Prerequisite: BIO250Y1, BCH210H1/BCH242Y1


BCH471Y1
Advanced Biochemistry Laboratory       168P

Experiments demonstrating modern concepts of biochemistry and molecular biology. (Enrolment limited)
Prerequisite: (BCH335H1 + BCH340H1 + BCH371H1)/(CHM361H5 [UTM] + 362H5 [UTM] + 371H5 [UTM]) + MGY311Y1


BCH473Y1
Advanced Research Project in Biochemistry       154P

Research in a particular area of biochemistry, by arrangement with the Department and the instructor concerned. Students must have a minimum GPA of 3.0.
Prerequisite: BCH335H1 + BCH340H1 + BCH371H1, and permission of Department
Co-requisite: BCH471Y1