See page 27 for Key to Course Descriptions.
For Distribution Requirement purposes, all PCL courses are classified as SCIENCE courses (see page 22).

| Course Winter Timetable |

PCL299Y1
Research Opportunity Program

Credit course for supervised participation in faculty research project. See page 40 for details.

PCL201H1
Introduction to Pharmacology: Pharmacokinetic Principles        39L, 13T

Topics include absorption, distribution, biotransformation, elimination, calculation of dosages, variability in drug response and adverse drug reactions.
Recommended Co-requisites: BIO250Y1, CHM217H1/CHM220H1, CHM247H1/CHM249H1

PCL302H1
Introduction to Pharmacology: Pharmacodynamic Principles        39L, 13T

Topics include biological action of drugs on membranes, enzymes, receptors, neural and hormonal systems, transmission and modulation.
Prerequisites: BIO250Y1, CHM217H1/CHM220H1, CHM247H1/CHM249H1, PCL201H1/301H1 and permission of Department

PCL362H1
Introductory Toxicology        26L

Toxicological problems encountered in animals and humans; biochemical mechanisms and clinical factors of toxicological significance; models of drug-related diseases.
Prerequisites: BCH210H1, BIO250Y1, CHM217H1/CHM220H1, CHM247H1/CHM249H1, PCL201H1 and permission of Department
Recommended Co-requisite: BIO349H1, PCL302H1

PCL376H1
Experimental Design and Data Analysis for Pharmacology and Toxicology        26L

A practically oriented course, focused on experimental design and the analysis of pharmacological and toxicological data. Topics include: principles of experimental design, data analysis and statistical tests appropriate for each type, use of computing statistical packages, analysis of dose-response and time-response curves and analysis of receptor binding assays. (See NOTE number 4, below).
Prerequisite: PCL201H1 and permission of Department
Co-requisite: PCL302H1 and permission of Department (see also NOTE number 4, below)

Exclusion: PCL476H1

PCL470Y1
Systems Pharmacology        78L

Concepts of the properties of drugs and chemicals and their interaction with living systems and their constituent parts. Mechanism of action and pharmacological properties of drugs acting on the autonomic and central nervous systems, cardiovascular, renal, respiratory, gastrointestinal, immunological and endocrine systems; endogenous compounds; antimicrobial and anti-inflammatory drugs, chemotherapy and special topics in pharmacology.
Prerequisites: BCH210H1, BIO349H1, PCL201H1, PCL302H1, PSL302Y1 and permission of Department

PCL471Y1
Pharmacology Laboratory        104P

Demonstrations, seminars, and laboratory exercises in selected areas of Pharmacology.
Prerequisites: BCH370H1, PSL372H1, PCL201H1, PCL302H1 and permission of Department (see NOTE number 1, below)
Co-requisite: PCL470Y1

PCL472Y1
Project in Pharmacology

A research project course providing intensive practical experience in a laboratory or applied pharmacology setting. Students will work under the supervision of a staff member and will submit a final written report. (See NOTES number 2 and 4, below).
Prerequisites: PCL201H1, PCL302H1, PCL376H1 (see NOTE number 4, below) and permission of Department
Co-requisite: PCL476H1 (see NOTE number 4, below)

Exclusion: PCL474Y1

PCL473Y1
Interdisciplinary Toxicology        52L

Traditional and contemporary problems in toxicology: general aspects, methodology, nature of toxic damage, general biological problems, poisons, applications and social policies.
Prerequisites: BCH210H1/310H1, BIO349H1, PCL201H1/301H1, PCL302H1, PCL362H1 and permission of Department

PCL474Y1
Project in Toxicology

A research project course providing intensive practical experience in a laboratory or applied toxicology setting. Students will work under the supervision of a staff member and will submit a final written report. (See NOTES number 2 and 4, below).
Prerequisites: PCL201H1, PCL302H1, PCL376H1 (see NOTE number 4, below) and permission of Department
Co-requisite: PCL476H1 (see NOTE number 4, below)

Exclusion: PCL472Y1

PCL475Y1
Neuropsychopharmacology        78L, 26T

Major neuro-psychiatric disease syndromes: clinical pathology and neuronal abnormalities; CNS drugs: theories and mechanisms of action.
Prerequisite: Permission of Department (see NOTE number 3, below)

PCL476H1
Experimental Design and Data Analysis for Pharmacology and Toxicology        26L

A practically oriented course, focused on experimental design and the analysis of pharmacological and toxicological data. Topics include: principles of experimental design, data analysis and statistical tests appropriate for each type, use of computing statistical packages, analysis of dose-response and time-response curves and analysis of receptor binding assays. (See NOTE number 4, below).
Prerequisite: PCL201H1, PCL302H1 and permission of Department
Co-requisite: PCL472Y1/PCL474Y1 (see NOTE number 4, below)

Exclusion: PCL376H1

PCL481H1
The Molecular and Biochemical Basis of Toxicology        26L

The biochemical principles and molecular mechanisms underlying the toxicity of drugs and foreign agents. The sequence of events at the molecular level leading to impairment of cell function and the factors which determine and affect toxicity.
Prerequisites: BCH210H1/310H1, BIO349H1, LMP 363H1, PCL362H1 and permission of Department
NOTES
1. Enrolment in the Pharmacology Laboratory course, PCL471Y1, is restricted to students enrolled in the Pharmacology and Double Specialist programs.
2. The research project courses, PCL472Y1 and PCL474Y1, require the prior consent of an approved supervisor to supervise the project, and departmental approval before enrolment. Student and supervisor must follow the departmental guidelines for evaluation. It is the student's responsibility to initiate all necessary preparations before the session starts.
3. Enrolment in PCL475Y1 is limited to students with a minimum CGPA of 3.0.
4. PCL376H1/PCL476H1 is restricted to students enrolled in one of the three specialist programs offered by the Department of Pharmacology. PCL376H1/PCL476H1 can be taken either as a pre-requisite (PCL376H1) or a Co-requisite (PCL476H1) to the project course PCL472Y1/PCL474Y1.