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Molecular Genetics and Microbiology Courses |
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MGY299Y1 Credit course for supervised participation in faculty research project. See page 40 for details. MGY311Y1 DNA replication, DNA repair and mutation, recombination, transcription, RNA modification and processing, the genetic code and tRNA, translation, regulation of gene expression, development and differentiation, molecular evolution. MGY312H1 Laboratory experiments in genetics of selected organisms. Topics studied include Mendelian genetics, linkage and recombination, complementation, analysis of chromosome rearrangements, mutant selection and analysis in plants and bacteria, and genetic crosses with Drosophila, plants, bacteria and bacteriophages. MGY376H1 Fundamental laboratory techniques in bacteriology and virology. Valuable not only for students specializing in Microbiology but also for those in related disciplines which make use of bacteria and viruses as research tools. Open to students in related programs. MGY377H1 Detailed study of bacteria in terms of structure, classification and replication. Basis for advanced study in various aspects of bacteriology including bacterial physiology, bacterial genetics, molecular pathogenesis of disease and environmental studies. MGY378H1 Detailed study of viruses in terms of structure, classification, replication and interaction with the host. Basis for advanced study in virology. Requires some familiarity with immunology. A concurrent course in immunology (IMM334Y1/IMM335Y1) is recommended. MGY420H1 This course describes regulatory mechanisms controlling gene expression in prokaryotes and eukaryotes. The lectures are designed to promote discussion of various experimental approaches. Topics include: assembly of a transcription complex; initiation of transcription; role of sigma factors and transcription factors; role of regulators of transcription; regulation of SV40 transcription; lambda antitermination; antitermination in HIV-1. MGY425H1 This course presents and integrates molecular aspects of signal transduction and cell cycle regulation in eukaryotic cells from yeast to humans. Emphasis is on recent advances in growth factor receptor signalling, modular protein domains, and the recurrent role of protein phosphorylation and protein-protein interactions in cell regulation. MGY428H1 This course aims to explore and understand microbial genome diversity and the evolutionary dynamic of microbial genomes. Topics include: structure and diversity of microbial (eubacterial and archaebacterial) genomes; orientation and overall organization of genes at the genomic level; mobile genetic elements; restriction and modification systems; genome and codon evolution. MGY432H1 Laboratory experiments demonstrating basic and advanced molecular biological methods applied to molecular genetics and microbiology. MGY434H1 How bacteria sense their environment and signal to regulatory systems when to adapt to environmental stimuli. Topics discussed include the bacterial cell cycle, carbon/energy metabolism, catabolite repression, bacterial development, sporulation, stress responses, regulatory two-component systems and quorum sensing. MGY440H1 Analysis of virus/host interactions at the molecular level. Course material is based on recent research publications. MGY445H1 Current approaches to gene therapy including design of virus-based vectors for delivery and expression of effector genes. Emphasis on the use of retrovirus-based strategies for prevention and treatment of HIV infection. MGY451H1 Basic and advanced principles of genetic analysis applied to the study of two of the best-understood eukaryotic model organisms: the yeast Saccharomyces cerevisiae, and the nematode worm Caenorhabditis elegans. We emphasize the use of genetic approaches to address problems in cell biology and development, such as the regulation of cell fate. Much of the knowledge gained from these simple organisms has proven broadly applicable, and the same principles of developmental genetic analysis underlie efforts to understand the development of more complex organisms. MGY452H1 This is a companion course to MGY451H1. Advanced genetic principles and approaches, used in the study of fly and mouse development, are introduced. Emphasis is placed on developmental processes that are conserved among these major model organisms. MGY460H1 Structure, organization, expression and regulation of genes in the nucleus, and chloroplast of photosynthetic organisms; regulation of gene expression during plant development and in response to the environment. MGY470H1 Current aspects of human and molecular genetics including: chromosome structure and function, inheritance of mutations and disease, the human genome and disease gene mapping, cancer genetics, mouse disease models and gene based diagnostics and therapies. MGY480Y1 An opportunity for specialized individual research in molecular genetics and microbiology by arrangement with the course coordinator. MGY485H1 Analysis of infectious disease vaccines; past, present and future, with an emphasis on molecular aspects. Special topics include: molecular basis of pathogenicity; vaccination strategies; genetically engineered vaccines; DNA vaccines; modulation of the immune response by vaccine adjuvants; adverse effects of vaccines. |
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