MPL299Y
Research Opportunity Program

Credit course for supervised participation in faculty research project. See page for details.

MPL375Y1
Microbiology 78L

Detailed study of bacteria and viruses in terms of structure, classification and replication. Basis for advanced study in virology and in various aspects of bacteriology including bacterial physiology, bacterial genetics, molecular pathogenesis of disease and environmental studies.
Exclusion: BIO351Y
Prerequisite: BIO250Y
Co-requisite: (BCH310H, JLM349H)/BCH 321Y

MPL376H11
Microbiology Laboratory 78P

Fundamental laboratory techniques in bacteriology and virology. Valuable not only for students specializing in Microbiology but also for those in related disciplines which make use of bacteria and viruses as research tools.
Prerequisite: BIO250Y
Co-requisite: MPL375Y

MPL422Y1
Research Project in Microbiology TBA

Under the supervision of a departmental staff member. (Open only to students who have completed Third Year with at least 'B+' standing)
Prerequisite: Permission of course coordinator

MPL424H1
Advanced Microbial Genetics (formerly MPL424Y) 26L

Analysis of genes and microbial genomes, regulatory mechanisms, evolution of genetic code, DNA restriction and modification systems, mutagenesis and DNA repair mechanisms, mobile genetic elements; principle and strategy of gene cloning and analysis.
Prerequisite: (BCH310H, JLM 349H)/BCH321Y; MGB311Y/MPL375Y
Recommended preparation: MGB311Y/JLM 349H

MPL434H1
Microbial Physiology and Regulation of Metabolism 39L

A survey of bacterial metabolism and its regulation from a basic knowledge of bacterial physiology, biochemistry and molecular biology. Emphasis is placed on mechanisms of sensing and adjusting to environmental stresses. Topics include: carbon/energy/metabolism and catabolite repression; adjustments to aerobic/anaerobic conditions, changes in osmolarity and starvation for amino acids, nitrogen and phosphate; chemoreceptors, bioluminescence, and response to environmental stress, such as DNA damage and heat shock.
Prerequisite: (BCH310H, JLM 349H)/BCH321Y; MGB311Y/MPL375Y

MPL436H1
Microbial Pathogenesis (formerly MPL436Y) 39L

Study of molecular mechanisms involved in pathogenesis of infectious disease. Topics include recurrent themes in the establishment of infectious disease, such as adherence and spread of pathogenic bacteria as well as evasion of host defences. Emphasis is placed on genetic characterization and expression of virulence determinants and on interactions between bacterial pathogens and their hosts.
Prerequisite: MPL375Y
Recommended preparation: IMM334Y

MPL440H1
Molecular Virology 39L

Analysis of virus/host interactions at the molecular level. Course material is based on recent research publications.
Prerequisite: (BCH310H, JLM 349H)/BCH321Y; MPL375Y
Recommended preparation: IMM334Y

MPL444H1
Environmental Microbiology 39L

Microorganisms normally exist in mixed communities whose composition and activity reflect the physical and chemical status of each particular niche. The structural analysis, nutrient cycling, and dynamics of microbe-microbe interactions in terrestrial, freshwater, and marine ecosystems are explored. The role of microorganisms in bioremediation is examined.
Prerequisite: MPL375Y or permission of instructor
Recommended preparation: (BCH310H, JLM349H)/BCH321Y

MPL445H1
Genetic Engineering for Prevention and Treatment of Disease 39L

Current approaches to gene therapy including design of virus-based vectors for delivery and expression of effector genes. Emphasis on the use of retrovirus-based strategies for prevention and treatment of HIV infection.
Prerequisite: JLM349H/MGB311Y/MPL375Y

MPL450H1
Current Methods in Molecular Microbiology 78P

A laboratory course focussing on the use of molecular techniques to identify microorganisms and to study microbial interactions with the host.
Prerequisite: MPL375Y; MPL376H/MGB312H; MGB430H or permission of instructor