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Chemistry CoursesFor Distribution Requirement purposes, all CHM courses are classified as SCIENCE courses. |
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SCI199H1 SCI199Y1 Undergraduate seminar that focuses on specific ideas, questions, phenomena or controversies, taught by a regular Faculty member deeply engaged in the discipline. Open only to newly-admitted first year students. It may serve as a distribution requirement course; see page 48. CHM138H1 An introduction to principles of structure and their relation to reactivity of organic molecules: molecular structure, stereochemistry, functional groups, and reactions. Recommended for students in life and health science programs that involve a small amount of chemistry CHM139H1 Structure of matter, gases, liquids and solids; phase equilibria and phase diagrams; colligative properties; chemical equilibria; electrolyte solutions and electrochemistry; reaction kinetics; introduction to thermodynamics. Recommended for students in life and health science programs that involve a small amount of chemistry CHM151Y1 An introduction to the major areas of modern chemistry, including organic and biological chemistry; physical chemistry and chemical physics; and inorganic/materials chemistry. The course is intended for students who will be following one of the chemistry specialist programs (including Biological Chemistry and Environmental Chemistry) or who will be including a substantial amount of chemistry in their degree (such as those following a chemistry major program). The combination of CHM151Y1 and CHM249H1 serves as a full year introductory course in organic chemistry with laboratory. CHM217H1 Introduction to the science of chemical measurement, from sampling through analysis to the interpretation of results, how water, food products, pharmaceuticals, and dietary supplements are analysed for content, quality, and potential contaminants. Also how to interpret experimental measurements, compare results and procedures, and calibrate analytical instrumentation. Through closely integrated lectures, laboratories, and tutorials, this highly practical course will introduce you to a variety of analytical techniques including volumetric methods, potentiometry, uv/visible and infrared spectrophotometry, flame atomic absorption spectrometry, and chromatography. CHM220H1 Introduction to thermodynamics; phase equilibrium, properties of mixtures, chemical equilibrium, electrochemistry; introduction to quantum mechanics and spectroscopy. This course is recommended for students in life and health science programs that involve a small amount of chemistry. Students enrolled in any chemistry specialist programs (including Biological Chemistry and Environmental Chemistry) or who will be including a substantial amount of chemistry in their degree (such as those following a chemistry major program), are strongly encouraged to take CHM225Y1. CHM221H1 A continuation of CHM220H1 for students wishing to take some additional material in Physical Chemistry. The course covers topics in quantum mechanics and spectroscopy as well as an introduction to reaction kinetics. CHM225Y1 Topics: introductory thermodynamics, first and second law and applications; chemical equilibrium; chemical kinetics; introductory quantum mechanics; spectroscopy. The course is intended for students who will be following one of the chemistry specialist programs (including Biological Chemistry and Environmental Chemistry) or who will be including a substantial amount of chemistry in their degree (such as those following a chemistry major program). ENV235Y1 (see Centre for Environment) CHM238Y1 The first part (with CHM338H1) of a two-year sequence in Inorganic Chemistry, designed to illustrate and systematize the rich variety of structures, physical properties and reactions of compounds of the elements across and down the Periodic Table. Introduction to structure, symmetry and bonding of molecules and lattices; acid-base and redox reactions; d-metal complexes; systematic chemistry of metals and elements of the s and p blocks; inorganic materials and solid state chemistry with applications in advanced technologies. CHM247H1 Reactions of organic compounds. Principles of mechanism, synthesis, and spectroscopy, continuing from CHM138H1. This course is recommended for students in life and health science programs that involve a small amount of chemistry. Students enrolled in any chemistry specialist programs (including Biological Chemistry and Environmental Chemistry) or who will be including a substantial amount of chemistry in their degree (such as those following a chemistry major program) are strongly encouraged to take CHM249H1. Tutorial (12T) is optional. CHM249H1 An introductory course in organic chemistry, based around the themes of structure, bonding, reaction mechanism and synthesis. Reactions are discussed with a view to understanding mechanism and how they are useful in the multi-step synthesis of medicinally and industrially important compounds. An introduction to the spectroscopy of organic molecules is also given, as well as discussion of topics relating to the biological behaviour of organic molecules and medicinal chemistry. This course continues from CHM151Y1 or CHM138H1 and is designed for students in the chemistry specialist and major programs. This course is highly recommended for students in the Biological Chemistry program. CHM299Y1 Credit course for supervised participation in faculty research project. See page 48 for details. CHM310H1 Major chemical pollutants and their sources, the environmental reactions they undergo, and how they become distributed throughout the environment. Focus is on the principal routes of chemical and biological degradation of toxicants; oxidation, photodegradation, hydrolysis, reduction, biotic metabolism, and microbial degradation. The principal physical processes by which chemicals move, concentrate, and dissipate. CHM317H1 Scope of instrumental analytical chemistry; Fourier transform IR absorption spectroscopy; molecular luminescence; emission spectroscopy; mass spectroscopy, electrochemical techniques; sensors; gas and high performance liquid chromatography; instrument design principles and applications in industry and the environment. CHM325H1 Fashioned to illustrate how inorganic and polymer materials chemistry can be rationally used to synthesize superconductors, metals, semiconductors, ceramics, elastomers, thermoplastics, thermosets and polymer liquid crystals, with properties that can be tailored for applications in a range of advanced technologies. Coverage is fairly broad and is organized to crosscut many aspects of the field. CHM326H1 This course introduces the postulates of quantum mechanics to develop the fundamental framework of quantum theory. A number of exactly soluble problems are treated in detail as examples. Perturbation theory is introduced in the context of understanding many body problems. Various applications to chemical bonding and molecular spectroscopy are covered in detail. CHM327H1 Students are exposed to experiments to help them experience modern physical chemistry. Labs designed to illustrate physical chemistry principles and practical techniques as well as their real world state of the art applications. The course also involves some lecture material to broaden the laboratory experience. CHM328H1 This course explores the microscopic description of macroscopic phenomena in chemistry. Statistical mechanics is introduced as the bridge between the microscopic and macroscopic views, and applied to a variety of chemical problems including reaction dynamics. More advanced topics in thermodynamics are introduced and discussed as required. CHM338H1 Further study of the structures, physical properties and reactions of compounds of the main group elements and the transition metals. Introductions to spectroscopy and structural analysis, reaction mechanisms, d- and f- block organometallic compounds, catalysis, structures of solids and bioinorganic chemistry. The weekly laboratory demonstrates aspects of transition metal chemistry. CHM342H1 An overview of the preparation of various classes of organic compounds. Strategies and tactics of synthetic organic chemistry using examples from natural products and pharmaceuticals. C-C bond formation, functional group reactivity, structure, stereochemistry and selectivity. CHM343H1 This laboratory course showcases modern organic synthesis techniques and introduces chemical research principles. It provides excellent preparation for a CHM499Y1 project in organic chemistry. Associated lectures teach theory and problem-solving approaches from a practical perspective. CHM347H1 An organic chemical approach to the structure and reactions of major classes of biological molecules: carbohydrates, amino acids, peptides and proteins, phosphates, lipids, heterocycles, vitamins, nucleotides and polynucleotides. This is achieved through studies of advanced stereochemistry, chemical modification, reactions and synthesis. In addition to lectures and reading from texts, there will be opportunities for independent written assignments on several of the topics. CHM348H1 An advanced survey of principles and methods that deal with organic chemical structure and reactivity: advanced stereochemistry, conformational analysis, reaction kinetics, isotope effects, mechanistic approaches, applications of free energy relationships, orbital transformations, systematization of mechanisms, testing hypotheses. CHM379H1 This course provides an opportunity to learn core techniques in biological chemistry in a small group laboratory setting. Lectures will discuss the theory behind the techniques and highlight how they are used in current biological chemistry research and practice. CHM398H0 CHM399Y0 An instructor-supervised group project in an off-campus setting. See page 48 for details. CHM410H1 An analytical theory, instrumental, and methodology course focused on the measurement of pollutants in soil, water, air, and biological tissues and the determination of physical/chemical properties including vapour pressure, degradation rates, partitioning. Lab experiments involve application of theory. CHM414H1 The development, design, and operation of biosensors and chemical sensors, including: biosensor technology, transducer theory and operation, device design and fabrication, surface modification and methods of surface analysis, flow injection analysis and chemometrics. CHM415H1 This course considers the chemistry occurring in the Earth’s atmosphere, with emphasis on developing molecular-level understanding of the photochemistry, free-radical kinetics, and heterogeneous chemistry that occurs. Topics include stratospheric ozone depletion, trace gas oxidation, urban air pollution, acid rain, and the connections between aerosols and climate. CHM416H1 Principles of separation in analytical chemistry. Fractionation processes and solvent extractions; theory of chromatography, retention time, column efficiency and resolution. Principles of gas-liquid chromatography; instrumentation for gas chromatography. High performance liquid chromatography - practice and equipment design. Ion exchange, size-exclusion and affinity chromatography. Electrophoretic techniques. CHM417H1 Basic understanding of components used in machines conventionally applied to chemical analysis and research. Electronic circuits and measurement; optical components; analog-digital conversion; lock-in amplifiers and frequency counters; interfaces for data acquisition and LabView; signal control. CHM421H1 The course provides an introduction to 1) molecular reaction dynamics (potential energy surfaces, bimolecular collisions, dynamics of bimolecular and unimolecular reactions, transition state theory) and to the modern tools (often laser based) to explore such dynamics, 2) relation of dynamics to classical chemical kinetics (rate, rate laws and mechanisms), 3) modern methods to control molecular processes. CHM423H1 Applications of time independent and time dependent perturbation theory to atomic and molecular problems, selection of topics from WKB approximation and the classical limit; the interaction of light with matter; elementary atomic scattering theory; molecular bonding. CHM426H1 Scope of polymer chemistry. Classification of polymers. Synthesis and characterization. Polymers in solution. Thermodynamics of polymer solutions and blends, Flory-Huggins theory. Polymers in the solid state. Crystalline and amorphous polymers. Glass transition and melting temperature. Mechanical properties. Polymers as advanced materials. CHM427H1 Ensemble theory in statistical mechanics. Applications, including imperfect gases and liquid theories. Introduction to non-equilibrium problems. CHM432H1 Structure, bonding, and reactions of organometallic compounds, with emphasis on basic mechanisms, and industrial processes. Addition, metalation, substitution, elimination, important catalytic cycles, electrophilic, and nucleophilic reactions are considered on a mechanistic basis. Properties of s and p block organometallics. CHM434H1 A comprehensive investigation of synthetic methods for preparing diverse classes of inorganic materials with properties intentionally tailored for a particular use. Begins with a primer on solid-state materials and electronic band description of solids followed by a survey of archetypical solids that have had a dramatic influence on the materials world, some new developments in materials chemistry and a look at perceived future developments in materials research and technology. Strategies for synthesizing many different classes of materials with intentionally designed structures and compositions, textures and morphologies are then explored in detail emphasizing how to control the relations between structure and property of materials and ultimately function and utility. A number of contemporary issues in materials research are critically evaluated to appreciate recent highlights in the field of materials chemistry - an emerging sub-discipline of chemistry. CHM437H1 Essential elements in biology; naturally occurring and medicinal ligands; transport, uptake and control of concentration of metal ions; physical methods of characterization of metal binding sites. Roles of metal ions: as structural and signaling elements in proteins, nucleic acids and DNA-binding complexes and proteins; as Lewis-acid centres in enzymes; as carriers of electrons, atoms and groups in redox proteins and enzymes; as sources of biominerals; as radiopharmaceuticals. CHM438H1 The 4-week format of the lab bridges the gap between typical undergraduate labs and the realities of academic and industrial research and provides an exceptional educational opportunity for students intending to do CHM499Y1 research and/or considering going on in graduate studies. The lab is open throughout the day for the first four weeks of the fall term and instructional staff are available during this time to provide guidance on an individual basis. Applications for enrolment should be made to the Department in the preceding Winter Session. CHM440H1 This course provides an overview of reactions and synthetic strategies that are being used at different stages of the drug development process. Using representative examples from the literature, we will concentrate on synthesis of complex heterocyclic compounds. CHM441H1 Structure and stereochemistry determination using modern spectroscopic techniques. Several techniques are discussed but particular emphasis is given to NMR (1H and 13C NMR) and mass spectrometry. The approach taken emphasizes applications of these spectroscopic methods to organic problems. Students are trained to run their own spectra (IR, UV, NMR, GC-MS). CHM443H1 Noncovalent binding forces, solutions, and molecular recognition. Electronic structure theory and computational techniques. Reaction mechanisms: experimental probes and reactive intermediates, including carbenes and radicals. Photophysics and photochemistry of organic compounds. CHM447H1 Applications of principles of physical organic chemistry to the study of biologically important processes: principles of catalysis, acceleration mechanisms, enthalpy and entropy barriers, magnitudes of enzymatic rate constants, enzyme kinetics, mechanisms of inhibition, pH-dependence, stereochemical analysis, reaction patterns, selected cofactor mechanisms, case studies of enzymes, additional topics. CHM479H1 An in depth examination of biological systems at the molecular level. Several complex, multi-component molecular machines with a central role in life will be examined. For each system studied, the focus will be on understanding the chemical mechanisms that underlie the biological activities, and how these processes fit into a cellular context. CHM499Y1 An experimental or theoretical research problem under the supervision of a faculty member. Applications for enrolment should be made to the Department in the preceding Winter Session. Projects in the areas of environmental, analytical, physical, inorganic, materials, organic and biological chemistry are offered*. |