Bioinformatics & Computational Biology CoursesFor Distribution Requirement purposes, all BCB courses are classified as SCIENCE courses (see page 27). For details on BCB courses, see www.biochemistry.utoronto.ca/bcb Biochemistry CoursesFor
Distribution Requirement purposes, all BCH courses are classified as SCIENCE
courses (see page 27). |
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BCB410H1 Practical introduction to concepts, standards and tools for the implementation of strategies in bioinformatics and computational biology. BCB420H1 Current approaches to using the computer for modeling biology as integrated molecular systems. BCB430Y1 An opportunity for specialized individual research in bioinformatics and computational biology by arrangement with the course coordinator and a supervisor. BCH299Y1 Credit course for supervised participation in faculty research project. See page 47 for details. BCH210H1 An introductory course in biochemistry covering proteins, enzymes, and metabolism. This course is intended for students who are NOT taking BCH242Y1 as part of their program. BCH242Y1 An introduction to biochemistry for students specializing in biochemistry and related specialist programs. The major topics include protein structure, enzyme mechanisms, carbohydrates, metabolism and bioenenergetics, lipids, membranes, structure of DNA and RNA. BCH304H1 Principles and concepts of cell biology; structure, molecular organization and dynamic cell-cell and cell-extracellular matrix interactions during cell migration, cell adhesion, cell polarity and tissue organization and the role of cytoskeletal components and cell surface receptors in these processes. Approaches and imaging techniques used; contributions of cell biology to advances in medicine. BCH335H1 Structure of DNA and RNA. Catalytic RNAs (ribozymes). Aspects of DNA topology and chromatin structure. Restriction/modification and fundamentals of recombinant DNA technology. BCH340H1 Proteins are the main functional units of the cell. In this course, a detailed overview of protein structure, stability, folding, and protein-ligand interactions will be given with strong emphasis on discussing the basic principles in the field. Biophysical methods as well as theoretical approaches to studying protein stability and folding will be presented. Finally, proteomics approaches to map protein-protein interactions will be discussed. BCH370H1 Techniques in biochemical research and analytical laboratories. Intended for students who are not proceeding further in biochemistry. It is highly recommended that students take this course in their third year as space is limited and priority will go to third-year students. No enrolment will be permitted five days after the start of class. (Enrolment limited) BCH371H1 An introduction to laboratory techniques of modern biochemistry. Experiments illustrate and develop the concepts described in lecture courses, and prepare the student for advanced training in biochemical laboratory techniques. (Enrolment limited)
Students who have completed University of Toronto at Mississauga’s
CHM361H5 and 362H5 may enroll in 400-series lecture courses if they obtain
permission of the Department BCH422H1 Structural features of membrane proteins and methods of analysis. Function of membrane proteins as transporters, channels, pumps and receptors. Molecular aspects of disease processes linked to membrane proteins. BCH425H1 Theory and practice of modern biophysical techniques as applied in the study of structure and function of macromolecules; emphasis on protein X-ray crystallography, NMR, and other spectroscopic methods; discussion of selected examples. BCH426H1 A variety of questions relating to signal transduction are investigated. How is calcium regulated in the cell and how does calcium regulate cell function? How are extracellular signals received and transmitted by intracellular proteins to control cellular proliferation and differentiation? What signaling paths are triggered by insulin? JBI428H1 Molecular mechanisms involved in innate and adaptive immunity including the structure and function of immunoglobulins, the complement system, antigen processing and presentation and membrane signalling events. Emphasis is on experimental approaches and quantitative aspects. (Given jointly by the Departments of Biochemistry and Immunology) BCH440H1 Mechanisms of translation initiation and translational control, ribosome assembly and structure. Protein folding and molecular chaperones. Protein targeting and transport. Regulation of protein degradation. BCH441H1 This course covers the use of computers in biochemistry and molecular biology. The main topics include: structure and organization of sequence databases, genome databases, sequences alignment and search strategies, molecular evolution and methods for constructing phylogenetic trees. Recent advances in comparative genomics and proteomics are presented. Assignments focus on practical applications of web-based bioinformatics tools. BCH444H1 This course examines the molecular details of the secretory and endocytic pathways in the cell. Some of the specific topics covered will include protein translocation into the ER, chaperones and protein folding in the ER, retrotranslocation and protein degradation, the Unfolded Protein Response (UPR), vesicle biogenesis and ER-Golgi transport, regulated secretion, basic concepts in endocytosis and protein sorting in polarized cells. BCH445H1 Principles and concepts of cell biology are covered including structure, biogenesis, and dynamic behaviour of cell organelles. The roles of sub-nuclear structure in DNA replication and of vesicular transport in endocytosis, exocytosis and phagocytosis are emphasized, as are modern imaging techniques and contributions of cell biology to advances in medicine. BCH471Y1 Experiments demonstrating modern concepts of biochemistry and molecular biology. (Enrolment limited) BCH473Y1 Research in a particular area of biochemistry, by arrangement with the Department and the instructor concerned. Students must have a minimum GPA of 3.0. |