| Course Winter Timetable |

MBY299Y
Research Opportunity Program

Credit course for supervised participation in faculty research project. See page 42 for details.

MBY375Y1
Microbiology 78L

Detailed study of bacteria and viruses in terms of structure, classification and replication. Basis for advanced study in virology and in various aspects of bacteriology including bacterial physiology, bacterial genetics, molecular pathogenesis of disease and environmental studies.
Exclusion: BIO351Y
Prerequisite: BIO250Y
Co-requisite: (BCH310H, JLM349H)/BCH321Y

MBY376H1
Microbiology Laboratory 78P

Fundamental laboratory techniques in bacteriology and virology. Valuable not only for students specializing in Microbiology but also for those in related disciplines which make use of bacteria and viruses as research tools.
Prerequisite: BIO250Y
Co-requisite: MBY375Y

MBY422Y1
Research Project in Microbiology TBA

Under the supervision of a departmental staff member. (Open only to students who have completed Third Year with at least ‘B+’ standing)
Prerequisite: Permission of course coordinator

MBY428H1
Microbial Genomics 26L

This course aims to explore and understand microbial genome diversity and the evolutionary dynamic of microbial genomes. Topics include: structure and diversity of microbial (eubacterial and archaebacterial) genomes; orientation and overall organization of genes at the genomic level; mobile genetic elements; restriction and modification systems; genome and codon evolution.
Prerequisite: BCH310H; MBY375Y

MBY434H1
Microbial Physiology and Regulation of Metabolism 39L

A survey of bacterial metabolism and its regulation from a basic knowledge of bacterial physiology, biochemistry and molecular biology. Emphasis is placed on mechanisms of sensing and adjusting to environmental stresses. Topics include: carbon/energy/metabolism and catabolite repression; adjustments to aerobic/anaerobic conditions, changes in osmolarity and starvation for amino acids, nitrogen and phosphate; chemoreceptors, bioluminescence, and response to environmental stress, such as DNA damage and heat shock.
Prerequisite: (BCH310H, JLM 349H)/BCH321Y; MBY375Y/MGB311Y

MBY440H1
Molecular Virology 39L

Analysis of virus/host interactions at the molecular level. Course material is based on recent research publications.
Prerequisite: (BCH310H, JLM 349H)/BCH321Y; MBY375Y
Recommended preparation: IMM334Y

MBY444H1
Environmental Microbiology 39L

Microorganisms normally exist in mixed communities whose composition and activity reflect the physical and chemical status of each particular niche. The structural analysis, nutrient cycling, and dynamics of microbe-microbe interactions in terrestrial, freshwater, and marine ecosystems are explored. The role of microorganisms in bioremediation is examined.
Prerequisite: MBY375Y or permission of instructor
Recommended preparation: (BCH310H, JLM349H)/BCH321Y

MBY445H1
Genetic Engineering for Prevention and Treatment of Disease 39L

Current approaches to gene therapy including design of virus-based vectors for delivery and expression of effector genes. Emphasis on the use of retrovirus-based strategies for prevention and treatment of HIV infection.
Prerequisite: JLM349H/MBY375Y/MGB311Y

MBY450H1
Current Methods in Molecular Microbiology 78P

A laboratory course focussing on the use of molecular techniques to study microorganisms and their interactions with the host.
Prerequisite: MBY375Y; MBY376H/MGB312H; MGB430H or permission of instructor

MBY480H1
Vaccines and Vaccination 39L

Analysis of infectious disease vaccines; past, present and future, with an emphasis on molecular aspects. Special topics include: molecular basis of pathogenicity; vaccination strategies; genetically engineered vaccines; DNA vaccines; modulation of the immune response by vaccine adjuvants; adverse effects of vaccines.
Prerequisite: MBY375Y
Recommended preparation: IMM334Y