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D.G. Butler, M Sc, Ph D, D Sc, FRSA (ZOO)

L. Butler, MSA, Ph D (ZOO)

G.M. Clark, M Sc, Ph D (ZOO)

W.R. Cummins, B Sc, Ph D (University of Toronto Mississauga) (BOT)

N.G. Dengler, MS, Ph D (BOT)

S.S. Desser, M Sc, Ph D (ZOO)

W.G. Friend, B Sc, Ph D (W) (ZOO)

M.C. Heath, B Sc, Ph D, FRSC (BOT)

J.A. Hellebust, MA, Ph D (BOT)

V.J. Higgins, MS, Ph D (BOT)

P.A. Horgen, MS, Ph D (University of Toronto Mississauga)

R.L. Jefferies, B Sc, Ph D (BOT)

R.A. Liversage, AM, Ph D (ZOO)

Y. Masui, M Sc, Ph D (ZOO)

N. Mrosovsky, BA, PhD (ZOO)

B.H. Pomeranz, MD, CM, Ph D (ZOO)

T.E. Reed, BA, Ph D (ZOO)

B.I. Roots, B Sc, Ph D, D Sc, FRSC (ZOO)

I. Tallan, B Sc, Ph D (ZOO)

J.P. Williams, B Sc, Ph D (BOT)

† M.P. Winsor, M Phil, Ph D (V) (ZOO)

† J.H. Youson, M Sc, Ph D (University of Toronto Scarborough) (ZOO)

A.M. Zimmerman, MS, Ph D (ZOO)

D.R. Goring, M Sc, Ph D

S.L. Varmuza, MS, Ph D

U. Tepass, M Sc, Ph D

M.M. Campbell, B Sc, Ph D

M.G. AbouHaidar, M Sc, Ph D

† J.B. Anderson, BA, Ph D (University of Toronto Mississauga)

F.M. Barrett, M Sc, Ph D

T. Berleth, Diplom, Ph D

† R. Boonstra, B Sc, Ph D (University of Toronto Scarborough)

I.R. Brown, B Sc, Ph D (University of Toronto Scarborough)

J.R. Coleman, B Sc, Ph D (U)

† E. Edwards, M A Sc, Ph D

G.S. Espie, B Sc, Ph D (University of Toronto Mississauga)

† J.H. Fullard, M Sc, Ph D (University of Toronto Mississauga)

† R.R. Fulthorpe, M Sc, Ph D (University of Toronto Scarborough)

† L.M. Kohn, B Sc, Ph D (University of Toronto Mississauga)

† H.J. Kronzucker, B Sc, Ph D (University of Toronto Scarborough)

A.B. Lange, BS, Ph D (University of Toronto Mississauga)

E.W. Larsen, M Sc, Ph D

D.A. Lovejoy, B Sc, Ph D

P. McCourt, B Sc, Ph D

D.H. O’Day, M Sc, Ph D (University of Toronto Mississauga)

I. Orchard, B Sc, Ph D (University of Toronto Mississauga)

J.J.B. Smith, MA, Ph D (N)

† M.B. Sokolowski, B Sc, Ph D, FRSC (University of Toronto Mississauga)

S.S. Tobe, M Sc, Ph D, FRSC

G.C. Vanlerberghe, B Sc, Ph D (University of Toronto Scarborough)

R. Winklbauer, Dipl in Bio, Ph D

† J.S. Yeomans, BA, Ph D

L.T. Buck, B Sc, Ph D

D. Christendat, B Sc, Ph D

D. Godt, Dipl in Bio, Ph D

D.S. Guttman, B Sc, Ph D

C.A. Hasenkampf, MS, Ph D (University of Toronto Scarborough)

† A.C. Mason, M Sc, Ph D (University of Toronto Scarborough)

† J.-M. Moncalvo, M Sc, Ph D

S. Reid, B Sc, Ph D (University of Toronto Scarborough)

C.D. Riggs, B Sc, Ph D (University of Toronto Scarborough)

M.J. Ringuette, B Sc, Ph D

P.A. Romans, M Sc, Ph D

R. Stephenson, B Sc, Ph D

B.A. Stewart, M Sc, Ph D (University of Toronto Mississauga)

J.T. Westwood, M Sc, Ph D (University of Toronto Mississauga)

M. Aarts, M Sc, Ph D (University of Toronto Scarborough)

A. Bruce, BA, Ph D

B. Chang, AB, Ph D

† A. Cutter, B Sc, Ph D

D. Desveaux, M Sc, Ph D

S. Gazzarrini, M Sc, Ph D (University of Toronto Scarborough)

T.J. Harris, B Sc, Ph D

† R. Harrison, M Sc, Ph D (University of Toronto Scarborough)

† J. Levine, BA, Ph D (University of Toronto Mississauga)

† N.R. Lovejoy, M Sc, Ph D (University of Toronto Scarborough)

† E. Master, B Sc, Ph D

A. Moses, BA, Ph D

E. Nambara, M Sc, Ph D

J.E. Nash, M Res, Ph D (University of Toronto Scarborough)

J. Peever, M Sc, Ph D

N.J. Provart, M Sc, Ph D

† J.R. Stinchcombe, BA, Ph D

M. Terebiznik, Ph D (University of Toronto Scarborough)

V. Tropepe, B Sc, Ph D

M. Woodin, M Sc, Ph D

K. Yoshioka, MS, Ph D

M. Neumann, M Sc, Ph D

The study of life, biology, has been transformed in recent decades by powerful new ways of asking fundamental questions about how living organisms work. In particular, molecular approaches are revealing both the incredible complexity of organization at the cellular level, and the underlying principles drawn from chemistry, physics and information science that will eventually enable us to understand that complexity.

The Department of Cell and Systems Biology brings together biologists who study life at the level of molecules to functioning individual organisms. Cell Biology is a vibrant and broad discipline that seeks to understand the underlying molecular processes that control cell behaviour in a developmental and physiological context. In this broad sense, cell biology comprises molecular biology, developmental biology, genetics and physiology and their sub-disciplines. Systems biology is an exciting new discipline that studies dynamic networks in biological systems through the integration of large datasets arising from the genomics revolution. Computer modeling and bioinformatics are integrated with the study of detailed information about genomes (genomics), the temporal and spatial distribution of all gene transcripts (transcriptomics), cellular proteins and their physical interactions (proteomics), and small molecules that cells assimilate or synthesise (metabolomics).

Associate Chair (Undergraduate): Professor S. Varmuza (416-978-2759).

Contact the Undergraduate Office, Room 424 in the Ramsay Wright Laboratories (416-978-3477) and consult the departmental web site, www.csb.utoronto.ca.

Enrolment in this program requires completion of 4.0 FCEs; no minimum GPA is required.

First Year: BIO 150Y1; CHM (138H1, 139H1)/151Y1; JMB 170Y1/MAT 135Y1/136Y1/137Y1/157Y1/PHY (131H1, 132H1)/(151H1, 152H1)

1. BIO (240H1, 241H1)/255Y1

2. BIO (270H1, 271H1)

3. 1.5 FCEs from: CSB 325H1, 332H1, 343H1, 346H1, 347H1

4. 1.5 FCEs (at least 0.5 FCE must be at the 300+level) from: BCH 210H1; BIO 260H1/HMB 265H1; CSB 299Y1, 325H1, 327H1, 330H1, 331H1, 332H1, 343H1, 346H1, 347H1, 352H1, 425H1, 430H1, 445H1, 497H1/498Y1, 499Y1; EEB 263Y1; PSY 397H1; STA 220H1

Enrolment in the Specialist program is limited, and requires a minimum CGPA of 2.7. Enrolment also requires the completion of four courses, including BIO 150Y1; CHM (138H1, 139H1)/151Y1; JMB 170Y1/MAT 135Y1/136Y1/137Y1/157Y1.

Enrolment in the Major requires the completion of 4.0 FCEs; no minimum GPA is required.

(12.5 full courses or their equivalent, including at least one 400-series course)

BIO 150Y1; CHM (138H1, 139H1)/151Y1; JMB 170Y1/MAT 135Y1/136Y1/137Y1/157Y1; PHY (131H1, 132H1)/(151H1, 152H1)

1. BIO (240H1, 241H1)/255Y1, BIO (270H1, 271H1),BIO 260H1/HMB 265H1; BCH 210H1; CSB 349H1

2. CSB 330H1/350H1, CSB 331H1/BCH 304H1, CSB 428H1

3. 0.5 FCE from the following: BCH 422H1, 426H1, 445H1, CSB 327H1, 347H1

4. 3.0 FCEs from the following: BCH 440H1, BCH 441H1/CSB 472H1, CSB 299Y1, 328H1, 332H1, 340H1, 351Y1, 357H1, 427H1, 429H1, 430H1 450H1, 452H1, 458H1, 459H1, 473H1, 497H1/498Y1, 499Y1

First Year: BIO 150Y1; CHM (138H1, 139H1)/151Y1; JMB 170Y1/MAT 135Y1/136Y1/137Y1/157Y1/PHY (131H1, 132H1)/(151H1, 152H1)

1. BIO (240H1, 241H1)1/255Y1

2. BIO 260H1/HMB 265H1; BCH 210H1

3. 1.5 FCE from: CSB 327H1, 328H1, 331H1, 340H1, 349H1, 351Y1

4. 1.5 FCE (at least 0.5 FCE must be at the 300+level) from: BCH 422H1, 444H1, 445H1,CSB 299Y1, 327H1, 328H1, 330H1, 331H1, 332H1, 340H1, 347H1, 349H1, 350H1, 351Y1, 352H1, 427H1, 428H1, 429H1, 458H1, 459H1, 460H1, 497H1/498Y1, 499Y1. No more than 0.5 FCE in BCH can be used towards this requirement.

Enrolment in this program is limited, and requires a minimum CGPA of 2.5. Enrolment also requires the completion of four courses, including BIO 150Y1; CHM (138H1, 139H1)/151Y1; JMB 170Y1/MAT 135Y1/136Y1/137Y1/157Y1.

(12.5 full courses or their equivalent, including at least one 400-series course)

BIO 150Y1; CHM (138H1, 139H1)/151Y1; JMB 170Y1/MAT 135Y1/136Y1/137Y1/157Y1

1. BCH 210H1; BIO (240H1, 241H1)/255Y1, BIO 251Y1/(270H1, 271H1), BIO 260H1; CHM 220H1/247H1/249H1

2. CSB 349H1

3. CSB 328H1, 340H1

4. 2.5 (or 3.5*) courses from: ANA 300Y1, 301H1; BCH 304H1, 340H1, 370H1, 425H1, 426H1; CSB 327H1, 329H1, 330H1, 331H1, 350H1, 352H1, 425H1, 427H, 450H1, 459H1 460H1, 472H1, 473H1; EEB 340H1, 341H1, 460H1; IMM 334Y1, 429H1; JBI 428H1; MGY 425H1, 428H, 451H1, 452H1, 470H1; PSL 303Y1, 420H1

5. 1.0 (or 2.0*) courses from CSB 429H1, 430H1, 458H, 461H, 482Y1, 497H1/498Y1, 499Y1; MGY 480Y1

* Requirements 4 and 5 must include a total of at least 4.5 full courses

For Distribution Requirement purposes, all BIO and CSB courses are classified as SCIENCE courses (see page 26).

BIO240H1 Molecular Biology [26L, 18P]

An introduction to the structures and functions of DNA, RNA and proteins, exploring how the molecular information contained within an organism’s genome is converted into cellular function. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques

Exclusion: BIO 250Y1, 255Y1

Prerequisite: BIO150Y1BIO150Y1, CHM (138H1, 139H1)/151Y1

BIO241H1 Cell and Developmental Biology [26L, 18P]

An introduction to the structure and function of cells focusing on the molecular bases of cell and developmental biology. Lecture topics include membrane transport, protein sorting and cell communication plus cellular architecture and the formation of tissues. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques.

Exclusion: BIO 250Y1, 255Y1

BIO255Y1 Cell and Molecular Biology with Advanced Laboratory [52L, 36P]

An introduction to the structure and function of cells at the molecular level: key cellular macromolecules; transfer of genetic information; cell structure and function; cellular movement and division. The Enhanced Laboratory provides the opportunity for greater laboratory skill development in modern investigative techniques and is intended for students interested in conducting their own laboratory research.

Exclusion: BIO 240H1, 241H1, 250Y1

Prerequisite: BIO 150Y1, CHM (138H1, 139H1)/151Y1, cGPA 3.0

BIO260H1 Concepts in Genetics [39L, 13T]

This is a problem based course which discusses classical, molecular, developmental, and population genetics and genomics with emphasis on model organisms for genetic analysis.

BIO270H1 Animal Physiology I [26L, 9P]

The main ideas of physiology and the contribution of experimentation to our understanding of life processes. Uses examples from throughout the animal kingdom, and includes the physiology of homeostasis and the endocrine system. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques.

BIO271H1 Animal Physiology II [26L, 9P]

The main ideas of physiology and the contribution of experimentation to our understanding of life processes. Uses examples from throughout the animal kingdom, and includes the physiology of the nervous and cardiorespiratory systems. Accompanying laboratories reinforce the concepts introduced in lecture and teach relevant techniques.

CSB200Y1 Current Topics in Molecular Biology [52L, 26P]

This course is intended to provide non-science students with an understanding of basic concepts in molecular biology to allow them to explore, and analyze current scientific issues and controversies covered in the media and relevant to society at large.

This course counts as a Science Distribution Requirement for students in all years and disciplines; particularly suitable for Humanities and Social Science students.

Exclusion: BIO (240H1, 241H1)/250Y1/255Y1

Credit course for supervised participation in faculty research project. See page 48 for details.

Successful farming of tiger shrimp faces a number of biological, environmental and economic challenges. Some of these challenges are being met by gathering information pertaining to nutrition, growth , reproduction and disease resistance. During two weeks of field time in Thailand, students will learn the basic techniques in crustacean aquaculture and undertake individual projects related to these areas by using physiological and molecular biological techniques. Students must attend a one-day orientation in Toronto in May.

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO (270H1, 271H1)

The regulation of physiological processes by hormones and other signalling molecules in chordates. An integrated genes-to-environment approach is used to examine aspects of hormonal evolution, physiological information flow, behaviour and neuroendocrinology, and xenobiotic endocrine disruptors.

Prerequisite: BIO (270H1, 271H1)/PSL 302Y1

Examines expression, structure and function of the four major classes of ECM macromolecules: collagen, proteoglycans, non-collagenous structural proteins and glycoproteins. In addition to forming elaborate networks that give tissues and organs their unique architectural design and biophysical properties, ECM molecules act as potent regulators of all cellular activities. Emphasis is placed on the morphoregulatory contribution(s) of ECM molecules to normal and pathological development.

Prerequisite: BIO (240H1, 241H1)/255Y1

CSB328H1 Developmental Biology (formerly ZOO 328H1) [26L, 26T]

Basic concepts in developmental biology. Early development of invertebrates and vertebrates will be discussed with emphasis on experimental and molecular analysis of developmental mechanisms. Tutorials demonstrate examples of descriptive and experimental embryology and discuss primary literature of selected topics in developmental biology.

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO 260H1/HMB 265H1

CSB329H1 Evolution of Development (formerly ZOO 329H1) [26L, 26T]

This course begins with a comparison of embryonic development in the major animal taxa. The evolution of developmental mechanisms is then considered with emphasis on the molecular and genetic basis of these mechanisms. Subsequent discussion examines the impact of developmental processes on the evolution of animal diversity. Tutorials feature the study of embryos representing diverse animal taxa.

Prerequisite: CSB 328H1/(BIO (240H1, 241H1)/255Y1, BIO 260H1/HMB 265H1 and permission of instructor)

CSB330H1 Techniques in Molecular, Cellular and Developmental Biology (formerly ZOO 330H1) [13L, 39P]

A laboratory based course in current research techniques, employing animal model organisms (fruit fly and zebrafish) and experimental methods including basic molecular and cell biology techniques.

Exclusion: MGY 432H1, ZOO 330H1

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO 260H1/HMB 265H1, CSB 328H1

The development of multicellular organisms is dependent on a broad variety of different cell-cell and cell-matrix adhesive mechanisms. The course examines the molecules and mechanisms involved and how they act in concert to regulate distinct developmental and physiological events. Emphasis is placed on the experimental approaches and technology used to study the molecular interactions and dynamics and alter structure-function relationships in cells and organisms.

Exclusion: BCH 304H1, ZOO 331H1

Prerequisite: BIO (240H1, 241H1)/255Y1

Examination of all aspects of the synapse in both the peripheral and central nervous systems of invertebrates and vertebrates. Topics include: synapse formation, synaptic transmission, synaptic plasticity, learning and memory, and neurological disorders.

Prerequisite: BIO (270H1, 271H1)/PSL 201Y1/302Y1

Plant developmental genetics at the molecular, cellular and organismal level, generation and use of genomic resourses in plant model organisms. Questions address the genetic dissection of plant embryo and meristem development, plant stem cell specification and tissue patterning. Genomic approaches applicable to plant biotechnology are also covered.

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO 260H1/(HMB 265H1 with a minimum grade of 73%)

CSB343H1 Animal Energetics [13L, 13S, 13T]

Animal structure and function, at all levels from molecule to whole animal, are dependent on energy. This course describes how the supply, consumption, transformation, exchange and storage of energy can facilitate, constrain and limit animal function. Emphasis is placed on systems level physiological function and whole animal performance.

Prerequisite: BIO (270H1, 271H1)/PSL 201Y1/302Y1

CSB346H1 Neurobiology of Respiration (formerly ZOO 346H1) [26L, 13T]

Integrated control of cardio-respiratory physiology and metabolism in mammals. Topics include exercise, diving, sleep and hibernation.

Prerequisite: BIO (270H1, 271H1)/ PSL 302Y1

In-depth survey of unique cellular adaptations of different tissues and organisms to overcome environmental stresses such as hypoxia. Emphasis is placed on cellular strategies, particularly second messenger responses, although systematic and whole organism responses will be investigated. Broad-ranging common strategies among diverse organisms are examined.

Prerequisite: BIO (270H1, 271H1)/PSL 302Y1

CSB349H1 Eukaryotic Gene Expression (formerly BIO349H1) [22L, 18T]

Genome structure and the regulation of gene expression in eukaryotic cells. Topics include gene duplication, repetitive DNA, transcription, RNA interference and expression profiling. Tutorials emphasize problem based learning exercises that relate to recent advances in the broad field of eukaryotic gene expression.

Exclusion: BIO 349H1, BCH 311H1, MGY 311Y1, 420H1, PSL 350H1

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO 260H1/HMB 265H1

CSB350H1 Laboratory in Molecular Plant Biology (formerly BOT 350H1) [26L, 39P]

Laboratory methods used in plant molecular biology research. Topics include vector construction, plant transformations, PCR, DNA blots, high-throughput screens, genetic mapping, and bioinformatic analyses.

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO 260H1/HMB 265H1

CSB351Y1 Introductory Virology (formerly BIO 351Y1) [52L, 104T]

An introduction to basic and medical virology. Attendance in tutorials is optional.

Prerequisite: BIO (240H1, 241H1)/255Y1

Use of available programs for analyzing biological data. This is an introductory course with a strong emphasis on hands-on methods meant for Biology and Human Biology/GGB specialists/majors. Some theory is introduced, but the main focus is on using extant bioinformatics tools to analyze data and generate biological hypotheses.

Exclusion: BCB Specialist program students, BIO 352H1

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO 260H1/HMB 265H1

Plants have co-evolved with microbes ever since their first appearance on land, resulting in sophisticated strategies of pathogenicity, symbiosis, commensalisms and mutualism. This course presents an overview of these strategies with examples of bacteria, fungi, oomycetes and viruses that have evolved intimate associations with plants.

CSB357H1 Biology of Vector-Borne Parasitic Diseases (formerly ZOO 357H1) [26L, 24P, 10T]

The biology of malaria and other medically important vector-borne parasitic diseases. Topics include history of medical parasitology, parasite development in human and invertebrate hosts, epidemiology, adaptations to intra- and extracellular life and switching between hosts, effects on host physiology, immunity and behaviour, implications for vaccine and vector control and lessons regarding zoonoses and emergent infectious diseases. Laboratories and discussions complement formal lectures.

Prerequisite: BIO (240H1, 241H1)/255Y1

An instructor-supervised group project in an off-campus setting. See page 48 for details.

CSB425H1 Endocrinology of Transformation (formerly ZOO 425H1) [26L, 13T]

The student will investigate the endocrine and paracrine signalling mechanisms that act to coordinate the reorganization of tissues in animals in special situations. The topics covered will include metamorphosis in agnathans and amphibians, sex change in teleost fishes, limb and regeneration in reptiles and amphibians, and neural regeneration in birds and mammals.

Prerequisite: CSB 325H1/PSL 424H1; CGPA 2.7

This course will consider some of the polymers and smaller molecules produced by plants, including their biosynthesis, their involvement in plant growth and survival, and their use by humans. The course will have a strong biochemistry, genetics and molecular biology emphasis, and an applied component, examining human uses of plants.

Prerequisite: BIO (240H1, 241H1)/CHE 354H1

Recommended preparation: BIO 260H1/HMB 265H1, CSB 350H1/459H1

CSB428H1 Advanced Cell Biology II: Cell Polarity and Cytoskeletal Dynamics [13L, 13S, 13T]

This advanced course covers cell polarity and cytoskeletal dynamics emphasizing current literature. For each topic, the course examines (1) the proteins involved, (2) their interactions and regulation, and (3) how they organize specific cellular structures. The coordination of these complexes required for orchestrating complex cellular processes are addressed.

Prerequisite: CSB 349H1/MGY 311Y1, BCH 304H1/CSB 328H1/331H1/340H1

CSB429H1 Germ Cell Biology (formerly ZOO 429H1) [13L, 13S, 13T]

This course will discuss the genetic and cell biological aspects of the development of gametes, gonads, and sex related traits in animals, including invertebrates and vertebrates. In the accompanying seminar, primary literature is used to discuss selected topics in germ cell biology.

CSB430H1 Developmental Neurobiology (formerly ZOO 430H1) [26L, 13T]

An examination of the molecular genetic basis of nervous system formation. Experimental evidence from recent studies in selected invertebrate and vertebrate model systems will be discussed. Topics include the evolution of neural development, neural cell fate determination, neurogenesis, pattern formation, and axon guidance.

Prerequisite: CSB 328H1/(NRS 201H1/HMB 204H1/PSY 290H1, NRS 202H1/HMB 320H1)

CSB445H1 Biology of Sleep (formerly CSB 345H1) [13L, 13S, 13T]

Covers theories on the biological function of sleep-wake states – why and how animals sleep. Integrates all levels of organization, including molecular biology, homeostasis, bioenergetics, neurophysiology, endocrinology, behaviour and evolution, with comparisons across phyla.

Prerequisite: BIO (270H1, 271H1)/PSL 302Y1

This course introduces students to proteomics and metabolomics approaches, such as mass spectrometry, structural biology, 2D gel electrophoresis, in understanding the regulation of metabolic pathways in plants.

Prerequisite: BIO (240H1, 241H1)/255Y1, BCH 210H1

This course explores the molecular strategies that microbes and plants have evolved to live with each other. The variety of strategies will be summarized with emphasis on the molecular mechanisms of pathogenic relationships.

CSB457H1 Vector Biology [26L, 26T]

Biology of vectors, primarily hematophagous insects, of human parasitic, microbial and viral diseases. Emphasis is on the cellular and molecular interactions between the vectors and the pathogens they transmit and on vector defense/immunity mechanisms mounted against them.

Prerequisite: CSB 349H1/MGY 311Y1, CSB 357H1

A seminar course exploring non-Mendelian phenomena in plants, fungi and animals that reveal aspects of genome organization and regulation that may provide insight into genome function and evolution.

Prerequisite: BIO 260H1/HMB 265H1, CSB 349H1/MGY 311Y1

This course introduces students to major features of gene expression and signal transduction in plants. Topics include strategies for generating transgenic plants and regulating gene expression, as well as the importance of signal transduction in plant growth and survival. How plants sense and respond at the molecular level to environmental stresses such as drought, salinity, cold and disease will be discussed. The application of this basic scientific information in biotechnological strategies for improving agronomic traits will also be addressed.

Plant development, ecological adaptation and crop plant productivity depend on the sophisticated potential of plants to sense and compute signals to regulate their responses. An arsenal of genetic and genomic tools is employed to elucidate these plant signal transduction pathways. Examples from the original literature will be used to introduce general concepts of plant signal transduction, molecular biology and genomics and their application in understanding and influencing plant growth and development.

CSB461H1 Chromosome Biology (formerly BIO461H1) [26L, 26T]

Exploration of the relationships between chromosome structure, function and behaviour. This is an upper level genetics course with considerable cell/molecular biology content. Topics include chromatin structure, essential chromosomal elements, control of mitotic and meiotic segregation, chromosome evolution, genomic imprinting. Tutorials emphasize student discussion of recent primary research papers.

Prerequisite: BIO (240H1, 241H1)/255Y1, BIO 260H1/HMB 265H1, CSB 349H1/HMB 321H/MGY 311Y1

CSB472H1 Computational Genomics and Bioinformatics (formerly BIO472H1) [26L, 13T]

Computational analyses of DNA and RNA expression data. Understanding biological databases, sequence alignment, sequence annotation, gene prediction, computational analysis of function, motif analysis, phylogenetic analysis, and microarray analysis. Applied, theoretical and statistical issues will be addressed.

Exclusion: BCH 441H1, BIO 472H1

Prerequisite: BIO (240H1, 241H1)/255Y1

This course surveys the field of Chemical Genomics, focusing on the analysis of biological problems using chemical approaches. Topics covered include chemical genetics, combinatorial chemistry and combinatorial strategies in molecular biology. Examines both the underlying biological and chemical concepts; however, the focus is primarily biological.

Prerequisite: BIO (240H1, 241H1)/255Y1, CHM 247H1

Recommended Preparation: BCH 210H1, BIO 260H1/HMB 265H1

This hands-on, laboratory based course, offered through the Centre for the Analysis of Genome Evolution and Function (CAGEF), will teach students how to produce and analyze data that are central to the fields of genomics and proteomics. Techniques taught include DNA and RNA extraction, PCR, DNA sequencing, quantitative PCR, transcript profiling using microarrays, 2D-gel proteome analysis, and associated bioinformatics analyses.

Prerequisite: BIO 260H1/HMB 265H1, BIO 255Y1/CSB 330H1/350H1 or by permission of the instructor

A class directed seminar analyzing the major problems in developmental biology from cellular, genetic, and molecular perspectives.

An original research project (a literature review alone is not sufficient) requiring the prior consent of a member of the Department to supervise the project. The topic is to be one mutually agreed on by the student and supervisor. They must arrange the time, place, and provision of any materials and submit to the Undergraduate Office a signed form of agreement outlining details prior to being enrolled. This course is normally open only to Fourth Year students with adequate background in Cell and Systems Biology. All students are required to make written and, perhaps, oral presentations of the results of their projects and participate in a poster session. A copy of a written report must be submitted to the Undergraduate Office.

Allows students to do a second independent project, supervision of which must be different from CSB 497H1/498Y1. Operates in the same manner as CSB 497H1/498Y1.