Cell & Systems Biology CoursesFor Distribution Requirement purposes, all BIO and CSB courses are
classified as SCIENCE courses (see page 27). |
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CSB200Y1 This course is intended to provide non-science students with an
understanding of basic concepts in molecular biology to allow them to
explore, and analyze current scientific issues and controversies covered
in the media and relevant to society at large. BIO250Y1 An introduction to the structure and function of cells at the molecular
level: key cellular macromolecules; transfer of genetic information; cell
structure and function; cellular movement and division; modern
investigative techniques. Consult web page for the most current
information: http://BIO250Y1.chass.utoronto.ca/
BIO252Y1 The main ideas of physiology and the contribution of experimentation to
our understanding of life processes. Uses examples from throughout the
animal kingdom, and includes the physiology of nervous, muscular, sensory
and endocrine systems, homeostasis and control mechanisms, respiration,
blood circulation, thermoregulation, and bioenergetics.
BIO255Y1 An introduction to the structure and function of cells at the molecular
level: key cellular macromolecules; transfer of genetic information; cell
structure and function; cellular movement and division. The Enhanced
Laboratory provides the opportunity for greater laboratory skill
development in modern investigative techniques and is intended for
students interested in conducting their own laboratory
research. BIO260H1 This is a problem based course which discusses classical, molecular,
developmental, and population genetics and genomics with emphasis on model
organisms for genetic analysis. CSB299Y1 Credit course for supervised participation in faculty research project.
See page 47 for details. CSB310H1 Successful farming of tiger shrimp faces a number of biological,
environmental and economic challenges. Some of these challenges are being
met by gathering information pertaining to nutrition, growth ,
reproduction and disease resistance. During two weeks of field time in
Thailand, students will learn the basic techniques in crustacean
aquaculture and undertake individual projects related to these areas by
using physiological and molecular biological techniques. Students must
attend a one-day orientation in Toronto in May. CSB325H1 The regulation of physiological processes by hormones and other
signalling molecules in chordates. An integrated genes-to-environment
approach is used to examine aspects of hormonal evolution, physiological
information flow, behaviour and neuroendocrinology, and xenobiotic
endocrine disruptors. CSB327H1 Examines expression, structure and function of the four major classes
of ECM macromolecules: collagen, proteoglycans, non-collagenous structural
proteins and glycoproteins. In addition to forming elaborate networks that
give tissues and organs their unique architectural design and biophysical
properties, ECM molecules act as potent regulators of all cellular
activities. Emphasis is placed on the morphoregulatory contribution(s) of
ECM molecules to normal and pathological
development. CSB328H1 Basic concepts in developmental biology. Early development of
invertebrates and vertebrates will be discussed with emphasis on
experimental and molecular analysis of developmental mechanisms. Tutorials
demonstrate examples of descriptive and experimental embryology and
discuss primary literature of selected topics in developmental
biology. CSB329H1 This course begins with a comparison of embryonic development in the
major animal taxa. The evolution of developmental mechanisms is then
considered with emphasis on the molecular and genetic basis of these
mechanisms. Subsequent discussion examines the impact of developmental
processes on the evolution of animal diversity. Tutorials feature the
study of embryos representing diverse animal
taxa. CSB330H1 A laboratory based course in current research techniques, employing
animal model organisms (fruit fly, zebrafish, frog) and experimental
methods including basic molecular and cell biology
techniques. CSB331H1 The development of multicellular organisms is dependent on a broad
variety of different cell-cell and cell-matrix adhesive mechanisms. The
course examines the molecules and mechanisms involved and how they act in
concert to regulate distinct developmental and physiological events.
Emphasis is placed on the experimental approaches and technology used to
study the molecular interactions and dynamics and alter structure-function
relationships in cells and organisms. CSB332H1 Examination of all aspects of the synapse in both the peripheral and
central nervous systems of invertebrates and vertebrates. Topics include:
synapse formation, synaptic transmission, synaptic plasticity, learning
and memory, and neurological disorders. CSB340H1 Plant developmental genetics at the molecular, cellular and organismal
level, generation and use of genomic resourses in plant model organisms.
Plant embryo and meristem development, as well as vascular tissue
patterning. Genomic approaches applicable to plant biotechnology are
included. CSB344H1 The importance of neurohormones and hormones in the regulation of
reproduction, growth, metamorphosis and metabolism in arthropods,
especially insects and crustaceans, molluscs, and other invertebrates.
CSB345H1 Covers theories on the biological function of sleep-wake states – why
and how animals sleep. Integrates all levels of organization, including
molecular biology, homeostasis, bioenergetics, neurophysiology,
endocrinology, behaviour and evolution, with comparisons across
phyla. CSB346H1 Integrated control of cardio-respiratory physiology and metabolism in
vertebrates. Topics include exercise, diving, sleep and hibernation.
CSB347H1 In-depth survey of unique cellular adaptations of different tissues and
organisms to overcome environmental stresses such as hypoxia. Emphasis is
placed on cellular strategies, particularly second messenger responses,
although systematic and whole organism responses will be investigated.
Broad-ranging common strategies among diverse organisms are examined.
CSB349H1 Genome structure and the regulation of gene expression in eukaryotic
cells. Topics include gene duplication, repetitive DNA, transcription, RNA
interference and expression profiling. Tutorials emphasize problem based
learning exercises that relate to recent advances in the broad field of
eukaryotic gene expression. CSB350H1 Laboratory methods used in plant molecular biology research. Topics
include vector construction, plant transformations, PCR, DNA blots,
high-throughput screens, genetic mapping, and bioinformatic
analyses. CSB351Y1 An introduction to basic and medical virology. Attendance in tutorials
is optional. CSB352H1 Use of available programs for analyzing biological data. This is an
introductory course with a strong emphasis on hands-on methods meant for
Biology and Human Biology/GGB specialists/majors. Some theory is
introduced, but the main focus is on using extant bioinformatics tools to
analyze data and generate biological hypotheses. CSB353H1 Plants have co-evolved with microbes ever since their first appearance
on land, resulting in sophisticated strategies of pathogenicity,
symbiosis, commensalisms and mutualism. This course presents an overview
of these strategies with examples of bacteria, fungi, oomycetes and
viruses that have evolved intimate associations with
plants. CSB357H1 The biology of malaria and other medically important vector-borne
parasitic diseases. Topics include history of medical parasitology,
parasite development in human and invertebrate hosts, epidemiology,
adaptations to intra- and extracellular life and switching between hosts,
effects on host physiology, immunity and behaviour, implications for
vaccine and vector control and lessons regarding zoonoses and emergent
infectious diseases. Laboratories and discussions complement formal
lectures. CSB398H0/ An instructor-supervised group project in an off-campus setting. See
page 47 for details. CSB425H1 The student will investigate the endocrine and paracrine signalling
mechanisms that act to coordinate the reorganization of tissues in animals
in special situations. The topics covered will include metamorphosis in
agnathans and amphibians, sex change in teleost fishes, limb and
regeneration in reptiles and amphibians, and neural regeneration in birds
and mammals. CSB428H1 This advanced course covers cell polarity and cytoskeletal dynamics
emphasizing current literature. For each topic, the course examines (1)
the proteins involved, (2) their interactions and regulation, and (3) how
they organize specific cellular structures. The coordination of these
complexes required for orchestrating complex cellular processes are
addressed. CSB429H1 This course will discuss the genetic and cell biological aspects of the
development of gametes, gonads, and sex related traits in animals,
including invertebrates and vertebrates. In the accompanying seminar,
primary literature is used to discuss selected topics in germ cell
biology. CSB430H1 An examination of the molecular genetic basis of nervous system
formation. Experimental evidence from recent studies in selected
invertebrate and vertebrate model systems will be discussed. Topics
include the evolution of neural development, neural cell fate
determination, neurogenesis, pattern formation, and axon
guidance. CSB450H1 This course introduces students to proteomics and metabolomics
approaches, such as mass spectrometry, structural biology, 2D gel
electrophoresis, in understanding the regulation of metabolic pathways in
plants. CSB452H1 This course explores the molecular strategies that microbes and plants
have evolved to live with each other. The variety of strategies will be
summarized with emphasis on the molecular mechanisms of pathogenic and
symbiotic relationships. CSB457H1 Biology of vectors, primarily hematophagous insects, of human
parasitic, microbial and viral diseases. Emphasis is on the cellular and
molecular interactions between the vectors and the pathogens they transmit
and on vector defense/immunity mechanisms mounted against
them. CSB458H1 A seminar course exploring non-Mendelian phenomena in plants, fungi and
animals that reveal aspects of genome organization and regulation that may
provide insight into genome function and
evolution. CSB459H1 This course introduces students to major features of gene expression
and signal transduction in plants. Topics include strategies for
generating transgenic plants and regulating gene expression, as well as
the importance of signal transduction in plant growth and survival. How
plants sense and respond at the molecular level to environmental stresses
such as drought, salinity, cold and disease will be discussed. The
application of this basic scientific information in biotechnological
strategies for improving agronomic traits will also be
addressed. CSB460H1 Structure, organization, expression and regulation of genes in the
nucleus and chloroplast of photosynthetic organisms; regulation of gene
expression during plant development and in response to the
environment. CSB461H1 Exploration of the relationships between chromosome structure, function
and behaviour. This is an upper level genetics course with considerable
cell/molecular biology content. Topics include chromatin structure,
essential chromosomal elements, control of mitotic and meiotic
segregation, chromosome evolution, genomic imprinting. Tutorials emphasize
student discussion of recent primary research
papers. CSB472H1 Computational analyses of DNA and RNA expression data. Understanding
biological databases, sequence alignment, sequence annotation, gene
prediction, computational analysis of function, motif analysis,
phylogenetic analysis, and microarray analysis. Applied, theoretical and
statistical issues will be addressed. CSB473H1 (formerly BIO473H1) CSB474H1 This hands-on, laboratory based course, offered through the Centre for
the Analysis of Genome Evolution and Function (CAGEF), will teach students
how to produce and analyze data that are central to the fields of genomics
and proteomics. Techniques taught include DNA and RNA extraction, PCR, DNA
sequencing, quantitative PCR, transcript profiling using microarrays,
2D-gel proteome analysis, and associated bioinformatics
analyses. CSB482Y1 A class directed seminar analyzing the major problems in developmental
biology from cellular, genetic, and molecular
perspectives. CSB485Y1 The experimental basis of modern animal physiology: techniques and
instrumentation and their importance to current physiological concepts,
using examples from the literature and the research programs of members of
the Department. CSB486H1 This course is designed for both 4th year undergraduate students in the
Comparative Animal Physiology Specialist Program and Graduate Students in
the early years of their program. The course focuses on the treatment and
presentation of complex physiological data using integrated and
comparative approaches. The format is a combination of lectures, group
discussions and student presentations. The final mark will be composed of
grades for student presentations, participation, a critique of scientific
manuscripts and final written report. CSB497H1/ An original research project (a literature review alone is not
sufficient) requiring the prior consent of a member of the Department to
supervise the project. The topic is to be one mutually agreed on by the
student and supervisor. They must arrange the time, place, and provision
of any materials and submit to the Undergraduate Office a signed form of
agreement outlining details prior to being enrolled. This course is
normally open only to Fourth Year students with adequate background in
Cell and Systems Biology. All students are required to make written and,
perhaps, oral presentations of the results of their projects and
participate in a poster session. A copy of a written report must be
submitted to the Undergraduate Office. CSB499Y1 Allows students to do a second independent project, supervision of
which must be different from CSB497H1/498Y1.
Operates in the same manner as CSB497H1/498Y1. |